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Research ArticleAdult Brain

Correlation of Tumor Immunohistochemistry with Dynamic Contrast-Enhanced and DSC-MRI Parameters in Patients with Gliomas

T.B. Nguyen, G.O. Cron, K. Bezzina, K. Perdrizet, C.H. Torres, S. Chakraborty, J. Woulfe, G.H. Jansen, R.E. Thornhill, B. Zanette and I.G. Cameron
American Journal of Neuroradiology December 2016, 37 (12) 2217-2223; DOI: https://doi.org/10.3174/ajnr.A4908
T.B. Nguyen
aFrom the Departments of Radiology (T.B.N., G.O.C., C.H.T., R.E.T., I.G.C., S.C.)
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G.O. Cron
aFrom the Departments of Radiology (T.B.N., G.O.C., C.H.T., R.E.T., I.G.C., S.C.)
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K. Bezzina
ePsychiatry (K.B.), The Ottawa Hospital, University of Ottawa, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
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K. Perdrizet
dInternal Medicine (K.P.)
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C.H. Torres
aFrom the Departments of Radiology (T.B.N., G.O.C., C.H.T., R.E.T., I.G.C., S.C.)
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S. Chakraborty
aFrom the Departments of Radiology (T.B.N., G.O.C., C.H.T., R.E.T., I.G.C., S.C.)
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J. Woulfe
cPathology (G.H.J., J.W.)
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G.H. Jansen
cPathology (G.H.J., J.W.)
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R.E. Thornhill
aFrom the Departments of Radiology (T.B.N., G.O.C., C.H.T., R.E.T., I.G.C., S.C.)
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B. Zanette
fDepartment of Medical Biophysics (B.Z.), University of Toronto, Toronto, Ontario, Canada.
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I.G. Cameron
aFrom the Departments of Radiology (T.B.N., G.O.C., C.H.T., R.E.T., I.G.C., S.C.)
bMedical Physics (I.G.C.)
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    Figure.

    Box-and-whisker plots of microvessel area according to histopathologic grade (A) and microvessel density according to histopathologic grade (B). The asterisk indicates P < .05.

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    Table 1:

    Median values of MVA, MVD, and DCE- and DSC-MRI parameters with interquartile range for low and high-grade gliomasa

    Low-Grade (n = 10)High-Grade (n = 33)P Value
    MVA (%)1.4 (0.66–2.09)3.2 (1.82–9.38).002
    MVD (mm2)129 (93–202)376 (157–768).006
    Large-tumor Vp_Φ (%)0.098 (0.01–0.58)1.45 (0.71–2.21).001
    Large-tumor Vp_SI (%)0.69 (0.27–2.20)3.12 (1.37–6.72).04
    Large-tumor uCBV (a.u.)35.8 (16.9–62.8)80.8 (57.3–152.5).01
    Large-tumor rCBV2.9 (1.53–4.19)5.43 (3.19–8.21).02
    Large-tumor Ktrans_Φ (min−1)0.00016 (0.00001–0.00225)0.019 (0.011–0.041).002
    Large-tumor Ktrans_SI (min−1)0.0012 (0.0004–0.0137)0.05 (0.0118–0.0773).004
    Hot spot Vp_Φ (%)0.46 (0.02–1.04)2.93 (1.85–4.42).0004
    Hot spot Vp_SI (%)1.84 (1.13–3.39)8.51 (4.14–13.80).015
    Hot spot uCBV (a.u.)40.2 (16.8–181.3)163 (142–274).002
    Hot spot rCBV2.85 (1.75–7.45)11.6 (6.48–18.50).008
    Hot spot Ktrans_Φ (min−1)0.00054 (0.00017–0.01341)0.047 (0.023–0.091).0006
    Hot spot Ktrans_SI (min−1)0.016 (0.002–0.067)0.095 (0.044–0.162).02
    • Note:—a.u. indicates arbitrary units.

    • ↵a Interquartile ranges are in parentheses.

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    Table 2:

    Diagnostic accuracy of imaging and histopathologic parameters in differentiating grade III and IV astrocytomas using hot spot ROIs

    ParametersAUC95% CICutoff ValueSensitivity (%)Specificity (%)
    MVA0.780.60–0.90<2.327773
    MVD0.620.44–0.78<1039536
    Hot spot Vp_Φ0.810.64–0.92<1.889173
    Hot spot Vp_SI0.660.47–0.81<4.29164
    Hot spot uCBV0.800.63–0.92<1418673
    Hot spot rCBV0.700.51–0.85<9.886873
    Hot spot Ktrans_Φ0.780.60–0.90<0.0248664
    Hot spot Ktrans_SI0.720.53–0.86<0.0568264
    Combined Vp_Φ + Ktrans_Φ + MVA + uCBV0.850.68–0.95<0.677782
    • Note:—AUC indicates area under the curve.

    • View popup
    Table 3:

    Median values for MVA and MVD with interquartile ranges for nonenhancing/poorly enhancing gliomas and moderately/strongly enhancing gliomasa

    Tumor EnhancementMVAMVD
    None/poor (n = 16)1.4% (0.68%–2.16%)187 mm2 (92–255 mm2)
    Moderate/strong (n = 27)4.9% (2.08%–10.19%)408 mm2 (156–842 mm2)
    P value.0002.04
    • ↵a Interquartile ranges are in parentheses.

    • View popup
    Table 4:

    Correlations (rs) among MVA, MVD, and DCE- and DSC-MRI parameters

    ParameterMVA (95% CI)P ValueMVD (95% CI)P Value
    Large-tumor Vp_Φ0.74 (0.57–0.85)<.00010.52 (0.26–0.71).0003
    Large-tumor Vp_SI0.52 (0.26–0.71).00030.29 (−0.14–0.54).06
    Large-tumor uCBV0.61 (0.37–0.77)<.00010.42 (0.14–0.64).005
    Large-tumor rCBV0.50 (0.23–0.69).00070.45 (0.18–0.66).002
    Large-tumor Ktrans_Φ0.57 (0.33–0.75).00010.36 (0.07–0.60).02
    Large-tumor Ktrans_SI0.56 (0.32–0.74).00010.41 (0.13–0.63).006
    Hot spot Vp_Φ0.69 (0.49–0.82)<.00010.46 (0.18–0.66).002
    Hot spot Vp_SI0.44 (0.16–0.65).0330.20 (−0.11–0.47).2
    Hot spot uCBV0.68 (0.48–0.82)<.00010.48 (0.21–0.68).001
    Hot spot rCBV0.55 (0.30–0.73).00010.47 (0.20–0.68).002
    Hot spot Ktrans_Φ0.56 (0.31–.74).00010.37 (0.073–0.60).02
    Hot spot Ktrans_SI0.54 (0.29–0.73).00020.32 (0.024–0.57).04
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American Journal of Neuroradiology: 37 (12)
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T.B. Nguyen, G.O. Cron, K. Bezzina, K. Perdrizet, C.H. Torres, S. Chakraborty, J. Woulfe, G.H. Jansen, R.E. Thornhill, B. Zanette, I.G. Cameron
Correlation of Tumor Immunohistochemistry with Dynamic Contrast-Enhanced and DSC-MRI Parameters in Patients with Gliomas
American Journal of Neuroradiology Dec 2016, 37 (12) 2217-2223; DOI: 10.3174/ajnr.A4908

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Correlation of Tumor Immunohistochemistry with Dynamic Contrast-Enhanced and DSC-MRI Parameters in Patients with Gliomas
T.B. Nguyen, G.O. Cron, K. Bezzina, K. Perdrizet, C.H. Torres, S. Chakraborty, J. Woulfe, G.H. Jansen, R.E. Thornhill, B. Zanette, I.G. Cameron
American Journal of Neuroradiology Dec 2016, 37 (12) 2217-2223; DOI: 10.3174/ajnr.A4908
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