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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleNeurointervention

Vascular Wall Imaging of Unruptured Cerebral Aneurysms with a Hybrid of Opposite-Contrast MR Angiography

T. Matsushige, Y. Akiyama, T. Okazaki, K. Shinagawa, N. Ichinose, K. Awai and K. Kurisu
American Journal of Neuroradiology August 2015, 36 (8) 1507-1511; DOI: https://doi.org/10.3174/ajnr.A4318
T. Matsushige
aFrom the Department of Neurosurgery (T.M., T.O., K.S., N.I., K.K.), Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
bDepartment of Neurosurgery (T.M.), University Hospital Essen, Essen, Germany
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Y. Akiyama
cDepartment of Diagnostic Radiology (Y.A., K.A.), Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
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T. Okazaki
aFrom the Department of Neurosurgery (T.M., T.O., K.S., N.I., K.K.), Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
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K. Shinagawa
aFrom the Department of Neurosurgery (T.M., T.O., K.S., N.I., K.K.), Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
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N. Ichinose
aFrom the Department of Neurosurgery (T.M., T.O., K.S., N.I., K.K.), Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
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K. Awai
cDepartment of Diagnostic Radiology (Y.A., K.A.), Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
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K. Kurisu
aFrom the Department of Neurosurgery (T.M., T.O., K.S., N.I., K.K.), Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
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    Fig 1.

    The distribution of WVCR in each plaque in the aneurysm wall. There is a significant difference in WVCR among A, B, and C (P = .0011). Group A indicates major plaques; group B, minor plaques; and group C, no plaques.

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    Fig 2.

    TOF-MRA (first column), FSBB (second column), and an intraoperative photomicrograph (third column) of 4 different patients with various degrees of atherosclerosis in the aneurysm wall. A, Left ICA–anterior choroidal artery unruptured aneurysm from case 1. TOF-MRA depicts the aneurysm (A-1, arrow) and left carotid artery (A-1, asterisk). FSBB shows high signal intensity in most of aneurysm wall with ROIs (green circle) in the wall (A-2, arrow) and at the center of the ipsilateral ICA for measuring the referring intensity (A-2, arrowhead). Intraoperative view showing abundant atherosclerotic plaques (grade A) in the aneurysm wall (A-3, arrow). B, Left MCA aneurysm from case 8. TOF-MRA shows the aneurysm (B-1, arrow). FSBB depicts focal high signal intensity in the aneurysm wall (B-2, arrow), corresponding to a patchy atherosclerotic plaque (grade B) in the intraoperative view (B-3, arrow). C, Right MCA aneurysm from case 3. TOF-MRA demonstrates the aneurysm (C-1, arrow). FSBB shows no high signal intensity in the wall (C-2, arrow), and the intraoperative view also shows no plaques (grade C) in the wall (C-3, arrow). D, Left AcomA aneurysm from case 10. TOF-MRA depicts the aneurysm (D-1, arrow), and FSBB shows no high signal intensity in the aneurysm wall (D-2, arrow). The operative view shows a small patchy atherosclerotic change on the right body of the aneurysm (D-3, arrow).

Tables

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  • Patient demographics and findings

    Case No.Aneurysm No.PatientsAneurysmsAneurysm Wall Findings at HOP-MRAAtherosclerotic Risk Factors
    SexAge (yr)LocationMaximum Size (mm)Intraoperative Plaque FindingsaHigh Signal IntensityWVCRbHTDLDMCS
    11M24ICA Ach4.2A+0.73+−−−
    22M35ACA (A1)2.8C−−0.02+−−+
    33M69MCA6.1C−−0.22−+−+
    44M76MCA14.1A+0.70+−−+
    55F71ICA PcomA5.9C−0.01−+−+
    6F71ICA terminal3.5NAc+0.64−+−+
    67F53dACA7.2A+0.68++−+
    8F53dACA6.7B+0.62++−+
    9F53AcomA4.2C−0.02++++
    710F63MCA5.4B+0.04++−−
    811F70MCA5.1B+0.44−+−−
    912M60AcomA4.7C−0.00+−−−
    1013F63AcomA5.0B−0.02++−−
    1114M61MCA7.2B+0.60+−−+
    1215F73MCA9.6A+0.75−−−−
    1316F55AcomA4.0C−0.04+−−+
    1417F69AcomA5.6C−0.03−+−−
    • Note:—Ach indicates anterior choroidal artery; PcomA, posterior communicating artery; ACA (A1), anterior cerebral artery (A1 segment); dACA, distal anterior cerebral artery; HT, hypertension; DL, dyslipidemia; DM, diabetes mellitus; CS, cigarette smoking; NA, not assessed due to anatomic reasons; +, present; −, absent.

    • ↵a Intraoperative plaque assessment in the aneurysm was demonstrated as the following: grade A, major plaques; grade B, minor plaques; grade C, no plaques.

    • ↵b WVCR indicates a high-intensity area in the aneurysm wall to the background low-intensity area inside the aneurysm.

    • ↵c Impossible to characterize the entire aneurysm due to anatomic reasons.

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American Journal of Neuroradiology: 36 (8)
American Journal of Neuroradiology
Vol. 36, Issue 8
1 Aug 2015
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Cite this article
T. Matsushige, Y. Akiyama, T. Okazaki, K. Shinagawa, N. Ichinose, K. Awai, K. Kurisu
Vascular Wall Imaging of Unruptured Cerebral Aneurysms with a Hybrid of Opposite-Contrast MR Angiography
American Journal of Neuroradiology Aug 2015, 36 (8) 1507-1511; DOI: 10.3174/ajnr.A4318

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Vascular Wall Imaging of Unruptured Cerebral Aneurysms with a Hybrid of Opposite-Contrast MR Angiography
T. Matsushige, Y. Akiyama, T. Okazaki, K. Shinagawa, N. Ichinose, K. Awai, K. Kurisu
American Journal of Neuroradiology Aug 2015, 36 (8) 1507-1511; DOI: 10.3174/ajnr.A4318
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