Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleNeurointervention

HydroCoils Reduce Recurrence Rates in Recently Ruptured Medium-Sized Intracranial Aneurysms: A Subgroup Analysis of the HELPS Trial

W. Brinjikji, P.M. White, H. Nahser, J. Wardlaw, R. Sellar, H.J. Cloft and D.F. Kallmes
American Journal of Neuroradiology June 2015, 36 (6) 1136-1141; DOI: https://doi.org/10.3174/ajnr.A4266
W. Brinjikji
aFrom the Department of Radiology (W.B., H.J.C., D.F.K.), Mayo Clinic, Rochester, Minnesota
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
P.M. White
bInstitute for Ageing and Health (P.M.W.), Newcastle University, Newcastle-upon-Tyne, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
H. Nahser
cDepartment of Clinical Neuroscience (H.N.), University of Edinburgh, Edinburgh, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J. Wardlaw
dWalton Centre (J.W., R.S.), Liverpool, United Kingdom.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
R. Sellar
dWalton Centre (J.W., R.S.), Liverpool, United Kingdom.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
H.J. Cloft
aFrom the Department of Radiology (W.B., H.J.C., D.F.K.), Mayo Clinic, Rochester, Minnesota
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D.F. Kallmes
aFrom the Department of Radiology (W.B., H.J.C., D.F.K.), Mayo Clinic, Rochester, Minnesota
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Crobeddu E,
    2. Lanzino G,
    3. Kallmes DF, et al
    . Review of 2 decades of aneurysm-recurrence literature. Part 2. Managing recurrence after endovascular coiling. AJNR Am J Neuroradiol 2013;34:481–85
    Abstract/FREE Full Text
  2. 2.↵
    1. Ringer AJ,
    2. Rodriguez-Mercado R,
    3. Veznedaroglu E, et al
    . Defining the risk of retreatment for aneurysm recurrence or residual after initial treatment by endovascular coiling: a multicenter study. Neurosurgery 2009;65:311–15; discussion 315
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Kallmes DF,
    2. Fujiwara NH
    . New expandable hydrogel-platinum coil hybrid device for aneurysm embolization. AJNR Am J Neuroradiol 2002;23:1580–88
    Abstract/FREE Full Text
  4. 4.↵
    1. Cloft HJ,
    2. Kallmes DF
    . Aneurysm packing with HydroCoil embolic system versus platinum coils: initial clinical experience. AJNR Am J Neuroradiol 2004;25:60–62
    Abstract/FREE Full Text
  5. 5.↵
    1. White PM,
    2. Lewis SC,
    3. Gholkar A, et al
    . Hydrogel-coated coils versus bare platinum coils for the endovascular treatment of intracranial aneurysms (HELPS): a randomised controlled trial. Lancet 2011;377:1655–62
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. Brinjikji W,
    2. Kallmes DF
    . Back to the tower of Babel: comparing outcomes from aneurysm trials. AJNR Am J Neuroradiol 2012;33:995–98
    FREE Full Text
  7. 7.↵
    1. Brinjikji W,
    2. Lanzino G,
    3. Cloft HJ, et al
    . Endovascular treatment of very small (3 mm or smaller) intracranial aneurysms: report of a consecutive series and a meta-analysis. Stroke 2010;41:116–21
    Abstract/FREE Full Text
  8. 8.↵
    1. Chalouhi N,
    2. Tjoumakaris S,
    3. Gonzalez LF, et al
    . Coiling of large and giant aneurysms: complications and long-term results of 334 cases. AJNR Am J Neuroradiol 2014;35:546–52
    Abstract/FREE Full Text
  9. 9.↵
    1. Ferns SP,
    2. Sprengers ME,
    3. van Rooij WJ, et al
    . Coiling of intracranial aneurysms: a systematic review on initial occlusion and reopening and retreatment rates. Stroke 2009;40:e523–29
    Abstract/FREE Full Text
  10. 10.↵
    1. Crobeddu E,
    2. Lanzino G,
    3. Kallmes DF, et al
    . Review of 2 decades of aneurysm-recurrence literature. Part 1. Reducing recurrence after endovascular coiling. AJNR Am J Neuroradiol 2013;34:266–70
    Abstract/FREE Full Text
  11. 11.↵
    1. White PM,
    2. Lewis SC,
    3. Nahser H, et al
    . HydroCoil Endovascular Aneurysm Occlusion and Packing Study (HELPS trial): procedural safety and operator-assessed efficacy results. AJNR Am J Neuroradiol 2008;29:217–23
    Abstract/FREE Full Text
  12. 12.↵
    1. Raymond J,
    2. Guilbert F,
    3. Weill A, et al
    . Long-term angiographic recurrences after selective endovascular treatment of aneurysms with detachable coils. Stroke 2003;34:1398–403
    Abstract/FREE Full Text
  13. 13.↵
    1. Molyneux AJ,
    2. Kerr RS,
    3. Yu LM, et al
    . International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and aneurysm occlusion. Lancet 2005;366:809–17
    CrossRefPubMedWeb of Science
  14. 14.↵
    1. Gaba RC,
    2. Ansari SA,
    3. Roy SS, et al
    . Embolization of intracranial aneurysms with hydrogel-coated coils versus inert platinum coils: effects on packing density, coil length and quantity, procedure performance, cost, length of hospital stay, and durability of therapy. Stroke 2006;37:1443–50
    Abstract/FREE Full Text
  15. 15.↵
    1. Watanabe K,
    2. Sugiu K,
    3. Tokunaga K, et al
    . Packing efficacy of HydroCoil embolic system: in vitro study using ruptured aneurysm model. Neurosurg Rev 2007;30:127–30; discussion 130
    CrossRefPubMed
  16. 16.↵
    1. Killer M,
    2. Arthur AS,
    3. Barr JD, et al
    . Histomorphology of thrombus organization, neointima formation, and foreign body response in retrieved human aneurysms treated with HydroCoil devices. J Biomed Mater Res B Appl Biomater 2010;94:486–92
    PubMed
  17. 17.↵
    1. Ding YH,
    2. Dai D,
    3. Lewis DA, et al
    . Angiographic and histologic analysis of experimental aneurysms embolized with platinum coils, Matrix, and HydroCoil. AJNR Am J Neuroradiol 2005;26:1757–63
    Abstract/FREE Full Text
  18. 18.↵
    1. Killer M,
    2. Hauser T,
    3. Wenger A, et al
    . Comparison of experimental aneurysms embolized with second-generation embolic devices and platinum coils. Acta Neurochir (Wien) 2009;151:497–505; discussion 505
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. Rezek I,
    2. Mousan G,
    3. Wang Z, et al
    . Coil type does not affect angiographic follow-up outcomes of cerebral aneurysm coiling: a systematic review and meta-analysis. AJNR Am J Neuroradiol 2013;34:1769–73
    Abstract/FREE Full Text
  20. 20.↵
    1. Wei D,
    2. Wei C,
    3. Huang S, et al
    . Comparison between effects of HydroCoil embolic system and ordinary coil on large- and medium-sized intracranial aneurysms. Pak J Med Sci 2013;29:1334–37
    PubMed
  21. 21.↵
    1. Lee JY,
    2. Seo JH,
    3. Lee SJ, et al
    . Mid-term outcome of intracranial aneurysms treated with HydroSoft coils compared to historical controls treated with bare platinum coils: a single-center experience. Acta Neurochir (Wien) 2014;156:1687–94
    CrossRefPubMed
  22. 22.↵
    1. Arthur AS,
    2. Wilson SA,
    3. Dixit S, et al
    . Hydrogel-coated coils for the treatment of cerebral aneurysms: preliminary results. Neurosurg Focus 2005;18:E1
    PubMed
  23. 23.↵
    1. Berenstein A,
    2. Song JK,
    3. Niimi Y, et al
    . Treatment of cerebral aneurysms with hydrogel-coated platinum coils (HydroCoil): early single-center experience. AJNR Am J Neuroradiol 2006;27:1834–40
    Abstract/FREE Full Text
  24. 24.↵
    1. Fanning NF,
    2. Berentei Z,
    3. Brennan PR, et al
    . HydroCoil as an adjuvant to bare platinum coil treatment of 100 cerebral aneurysms. Neuroradiology 2007;49:139–48
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Cloft HJ
    . HydroCoil for Endovascular Aneurysm Occlusion (HEAL) study: periprocedural results. AJNR Am J Neuroradiol 2006;27:289–92
    Abstract/FREE Full Text
  26. 26.↵
    1. Cloft HJ
    . HydroCoil for Endovascular Aneurysm Occlusion (HEAL) study: 3–6 month angiographic follow-up results. AJNR Am J Neuroradiol 2007;28:152–54
    Abstract/FREE Full Text
  27. 27.↵
    1. Assmann SF,
    2. Pocock SJ,
    3. Enos LE, et al
    . Subgroup analysis and other (mis)uses of baseline data in clinical trials. Lancet 2000;355:1064–69
    CrossRefPubMedWeb of Science
  28. 28.↵
    1. Motulsky HJ
    . Common misconceptions about data analysis and statistics. J Pharmacol Exp Ther 2014;351:200–05
    Abstract/FREE Full Text
  29. 29.↵
    1. Rezek I,
    2. Lingineni RK,
    3. Sneade M, et al
    . Differences in the angiographic evaluation of coiled cerebral aneurysms between a core laboratory reader and operators: results of the Cerecyte Coil Trial. AJNR Am J Neuroradiol 2014;35:124–27
    Abstract/FREE Full Text
  30. 30.↵
    1. Rezek I,
    2. Mousan G,
    3. Wang Z, et al
    . Effect of core laboratory and multiple-reader interpretation of angiographic images on follow-up outcomes of coiled cerebral aneurysms: a systematic review and meta-analysis. AJNR Am J Neuroradiol 2013;34:1380–84
    Abstract/FREE Full Text
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 36 (6)
American Journal of Neuroradiology
Vol. 36, Issue 6
1 Jun 2015
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
HydroCoils Reduce Recurrence Rates in Recently Ruptured Medium-Sized Intracranial Aneurysms: A Subgroup Analysis of the HELPS Trial
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
W. Brinjikji, P.M. White, H. Nahser, J. Wardlaw, R. Sellar, H.J. Cloft, D.F. Kallmes
HydroCoils Reduce Recurrence Rates in Recently Ruptured Medium-Sized Intracranial Aneurysms: A Subgroup Analysis of the HELPS Trial
American Journal of Neuroradiology Jun 2015, 36 (6) 1136-1141; DOI: 10.3174/ajnr.A4266

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
HydroCoils Reduce Recurrence Rates in Recently Ruptured Medium-Sized Intracranial Aneurysms: A Subgroup Analysis of the HELPS Trial
W. Brinjikji, P.M. White, H. Nahser, J. Wardlaw, R. Sellar, H.J. Cloft, D.F. Kallmes
American Journal of Neuroradiology Jun 2015, 36 (6) 1136-1141; DOI: 10.3174/ajnr.A4266
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATION:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Angiographic and clinical outcomes of balloon remodeling versus unassisted coil embolization in the ruptured aneurysm cohort of the GEL THE NEC study
  • Second-Generation Hydrogel Coils for the Endovascular Treatment of Intracranial Aneurysms: A Randomized Controlled Trial
  • GEL THE NEC: a prospective registry evaluating the safety, ease of use, and efficacy of the HydroSoft coil as a finishing device
  • Safety, immediate and mid-term results of the newer generation of hydrogel coils in the treatment of ruptured aneurysms: a multicenter study
  • Safety and effectiveness of large volume coils in the treatment of small aneurysms
  • Crossref (11)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Second-Generation Hydrogel Coils for the Endovascular Treatment of Intracranial Aneurysms
    Christian A. Taschner, René Chapot, Vincent Costalat, Paolo Machi, Patrick Courthéoux, Xavier Barreau, Jérôme Berge, Laurent Pierot, Krzysztof Kadziolka, Betty Jean, Raphaël Blanc, Alessandra Biondi, Hervé Brunel, Sophie Gallas, Ansgar Berlis, Denis Herbreteau, Joachim Berkefeld, Horst Urbach, Samer Elsheikh, Jens Fiehler, Hubert Desal, Erika Graf, Alain Bonafé
    Stroke 2018 49 3
  • The SMART Registry: Long-Term Results on the Utility of the Penumbra SMART COIL System for Treatment of Intracranial Aneurysms and Other Malformations
    Alejandro M. Spiotta, Min S. Park, Richard J. Bellon, Bradley N. Bohnstedt, Albert J. Yoo, Clemens M. Schirmer, Reade A. DeLeacy, David J. Fiorella, B. Keith Woodward, Harris E. Hawk, Ashish Nanda, Osama O. Zaidat, Peter J. Sunenshine, Kenneth C. Liu, Mouhammed R. Kabbani, Kenneth V. Snyder, Thinesh Sivapatham, Travis M. Dumont, Alan R. Reeves, Robert M. Starke
    Frontiers in Neurology 2021 12
  • GEL THE NEC: a prospective registry evaluating the safety, ease of use, and efficacy of the HydroSoft coil as a finishing device
    Waleed Brinjikji, Arun P Amar, Josser E Delgado Almandoz, Orlando Diaz, Pascal Jabbour, Ricardo Hanel, Ferdinand Hui, Michael Kelly, Kennith D Layton, Jeffrey W Miller, Elad Levy, Christopher Moran, Dae C Suh, Henry Woo, Robin Sellar, Brian Ho, Avery Evans, David F Kallmes
    Journal of NeuroInterventional Surgery 2018 10 1
  • Hydrogel coils versus bare platinum coils for the endovascular treatment of intracranial aneurysms: a meta-analysis of randomized controlled trials
    Tao Xue, Zhouqing Chen, Weiwei Lin, Jiayi Xu, Xuming Shen, Zhong Wang
    BMC Neurology 2018 18 1
  • Safety, immediate and mid-term results of the newer generation of hydrogel coils in the treatment of ruptured aneurysms: a multicenter study
    Guilherme Dabus, Lotfi Hacein-Bey, Bahram Varjavand, R Dana Tomalty, Patrick P Han, Vadim Yerokhin, Italo Linfante, J Mocco, Thomas Oxley, Alejandro Spiotta, M Imran Chaudry, Raymond D Turner, Aquilla S Turk
    Journal of NeuroInterventional Surgery 2017 9 4
  • Outcomes Associated With Intracranial Aneurysm Treatments Reported as Safe, Effective, or Durable
    Victor Volovici, Iris S. Verploegh, Djaina Satoer, Noëlle J. M. C. Vrancken Peeters, Yasmin Sadigh, Mervyn D. I. Vergouwen, Joost W. Schouten, Gavin Bruggeman, Dana Pisica, Gizem Yildirim, Ayca Cozar, Femke Muller, Ana-Maria Zidaru, Kelsey Gori, Nefeli Tzourmpaki, Esther Schnell, Mbaye Thioub, Kimberly Kicielinski, Pieter-Jan van Doormaal, Nikolay Velinov, Mahjouba Boutarbouch, Michael T. Lawton, Giuseppe Lanzino, Sepideh Amin-Hanjani, Ruben Dammers, Torstein R. Meling
    JAMA Network Open 2023 6 9
  • Safety and effectiveness of large volume coils in the treatment of small aneurysms
    Zsolt Kulcsár, Isabel Wanke, Daniel Rüfenacht, Stephan G Wetzel, Sophia Göricke, Kiriaki Kolia, Steven Quarfordt, Justin Calvert, Harris Hawk, Blaise Baxter
    Journal of NeuroInterventional Surgery 2016 8 12
  • Angiographic and clinical outcomes of balloon remodeling versus unassisted coil embolization in the ruptured aneurysm cohort of the GEL THE NEC study
    Guilherme Dabus, Waleed Brinjikji, Arun P Amar, Josser E Delgado Almandoz, Orlando M Diaz, Pascal Jabbour, Ricardo Hanel, Ferdinand Hui, Michael Kelly, Kennith F Layton, Jeffrey W Miller, Elad I Levy, Christopher J Moran, Dae Chul Suh, Henry Woo, Robbin Sellar, Brian Hoh, Avery Evans, David F Kallmes
    Journal of NeuroInterventional Surgery 2018 10 5
  • The evolution of non-reconstructive methods of endovascular treatment of cerebral aneurysms
    Vasiliy V. Bobinov, Larisa V. Rozhchenko, Sergey A. Goroshchenko, Egor G. Kolomin, Konstantin A. Samochernykh, Andrey E. Petrov
    Medical academic journal 2022 22 3
  • Comparison between second generation HydroSoft coils and bare platinum coils for the treatment of large intracranial aneurysms
    Agostino Tessitore, Aldo Paolucci, Sophia Hohenstatt, Antonio A Caragliano, Orazio Buonomo, Enricomaria Mormina, Antonio Pitrone, Sergio L Vinci
    Interventional Neuroradiology 2023 29 3

More in this TOC Section

  • Effect of SARS-CoV2 on Endovascular Thrombectomy
  • Flow diversion for distal circulation aneurysms
  • Neuroform Atlas Stent for Intracranial Aneurysms
Show more NEUROINTERVENTION

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire