Article Figures & Data
Figures
- Fig 1.
Upper left: lateral angiogram from right internal carotid artery injection. Upper Right: superselective microcatheter angiogram in the right M3 branch. Lower Left: 96-hour FLAIR image showing cortical infarct. Lower Right: 96-hour reconstructed coronal FLAIR image showing cortical infarct with sparing of the basal ganglia.
- Fig 2.
Upper: coronal FLAIR images showing cortical infarction at 96 hours. Lower: corresponding hematoxylin-eosin-stained anatomic sections following sacrifice.
Tables
- Table 1:
Experimental infarct volumes (cc) estimated from the diffusion-weighted images at various time intervals postocclusion
Stroke Timing RVI3 RCE3 RFP6 RJJ3 RFA5 RRI3 PH1019 RVG4 Average (±SEM) 6 Hours 3.3 8.8 0.6 4.6 4.9 1.6 0.5 1.2 3.18 ± 1.007 48 Hours 3.3 12.9 10.0 3.0 7.2 3.8 6.70 ± 1.666 96 Hours 9.5 3.3 8.6 7.5 7.23 ± 1.371 Note:—SEM indicates standard error of the mean; RV13, RCE3, RFP6, RJJ3, RFA5, RR13, PH1019, RVG4, rhesus monkey subjects.
Scoring Motor function Severe hemiparesis 10 Mild hemiparesis 25 Normal strength: favors opposite extremity 55 Normal strength: normal function 70 Behavior Death 0 Coma 1 Aware of surroundings: not active 5 Aware of surroundings: moves in response to examiner 15 Normal aggression 20 Ocular and cranial nerve function Facial movement: paretic 1 Facial movement: normal 5 Visual field: hemianopic 1 Visual field: normal 5 Subject Baseline 24 Hours 48 Hours 96 Hours Basal Ganglia Involvement Sxs RFP6 100 46 51 Yes Seizures RJJ3 100 21 21 No Severe hemiparesis, hemianopsia RFA5 100 46 85 85 No RRI3 100 81 85 85 No PH1019 100 85 85 85 No RVG4 100 85 85 81 No Mean 100 60.7 68.7 84 Note:—Sxs indicates major symptoms.
