Article Figures & Data
Figures
- Fig 1.
Scatterplots of the manual-versus-semiautomatic assessment of the degree of stenosis (percentage).
- Fig 2.
Bland-Altman plots of the degree of stenosis determined by manual and semiautomatic assessment. The black lines represent the mean paired difference and 95% limits of agreement. The characteristic V-shape in the Bland-Altman plot is caused by 1 of the 2 measurements being zero with the other measurement being nonzero. These measurements happened particularly when the degree of stenosis was small (<30%).
- Fig 3.
Scatterplot (upper left corner) and Bland-Altman plot (upper right corner) of the repeated manual stenosis measurement (percentage) (intraobserver). Scatterplot (lower left corner) and Bland-Altman plot (lower right corner) of the manual assessment of the degree of stenosis (percentage) measured by observer 1 and observer 2 (interobserver). The black lines in the right figures represent the mean paired difference and 95% limits of agreement.
- Fig 4.
Scatterplots of the repeated semiautomatic assessment of the degree of stenosis (percentage) measured by observers 1 and 2.
- Fig 5.
Bland-Altman plots of the repeated semiautomatic assessment of the degree of stenosis measured by observers 1 and 2. The black lines represent the mean paired difference and 95% limits of agreement.
- Fig 6.
Example of ulcerative plaque. On the left side how 3mensio segments the artery is shown, and in the right upper corner how 3mensio segments the lumen and the ulcerative plaque is shown. The turquoise line is the minimal stenosis diameter as determined by 3mensio (3.5 mm); the white-with-red line is a measurement of the true lumen (1.2 mm). The right lower corner shows a sagittal view of the ulceration. This image also shows 3mensio fitting an ellipse (yellow) on the segmented lumen of the artery (turquoise).
Tables
Average Processing Time ± SD (seconds) Manual measurements 138 ± 31 3mensio 86 ± 42 Philips 115 ± 77 TeraRecon 84 ± 64 Siemens 89 ± 86 Average Difference Degree of Stenosis ± SD (%) (Manual, Semiautomatic) Bland-Altman 95% Limits of Agreement (%) ICC for Degree of Stenosis (95% CI) 3mensio (observer 1) 3.8 ± 14 (P = .002) −24–31 0.86 (0.80–0.90) Philips (observer 1) 2.1 ± 13 (P = .049) −23–27 0.88 (0.83–0.91) TeraRecon (observer 1) 3.1 ± 13 (P = .007) −23–29 0.87 (0.82–0.90) Siemens (observer 1) 3.5 ± 13 (P = .002) −22–29 0.88 (0.83–0.91) - Table 3:
Diagnostic performance of semiautomatic measurement in detecting a stenosis degree of ≥70% and ≥50%
Sensitivity (95% CI) Specificity (95% CI) PPV (95% CI) NPV (95% CI) Accuracy (95% CI) 70% Cutoff 3mensio (observer 1) 62 (43–78) 96 (91–98) 76 (53–92) 92 (85–96) 89 (82–93) Philips (observer 1) 46 (29–65) 96 (91–99) 75 (48–93) 88 (82–94) 87 (80–92) TeraRecon (observer 1) 58 (37–77) 97 (93–99) 83 (59–96) 91 (85–95) 90 (84–94) Siemens (observer 1) 62 (40–81) 97 (91–99) 80 (56–94) 92 (85–96) 90 (84–94) 50% Cutoff 3mensio (observer 1) 77 (65–86) 93 (86–97) 91 (80–97) 83 (73–90) 86 (79–91) Philips (observer 1) 82 (70–89) 93 (86–97) 91 (81–97) 86 (76–92) 88 (81–93) TeraRecon (observer 1) 76 (65–86) 92 (84–97) 89 (78–96) 82 (73–90) 85 (78–90) Siemens (observer 1) 77 (65–86) 95 (87–99) 93 (82–98) 83 (73–90 87 (80–91) Note:—PPV indicates positive predictive value; NPV, negative predictive value.
Average Difference Degree of Stenosis ± SD (%) Bland-Altman Limits of Agreement (%) ICC (95% CI) for Degree of Stenosis Manual intraobserver (n = 38) 0.083 ± 13 −26–26 0.88 (0.79–0.94) Manual interobserver (n = 37) 2.6 ± 15 −28–32 0.81 (0.70–0.90) 3mensio interobserver (n = 141) 0.94 ± 7.5a (P = .007) −14–16 0.96 (0.95–0.97a (P < .001) Philips interobserver (n = 141) −2.8 ± 11 −23–18 0.90 (0.86–0.93)a (P = .0041) TeraRecon interobserver (n = 141) 7.0 ± 14 −20–34 0.83 (0.70–0.90) Siemens interobserver (n = 141) 6.5 ± 12 −17–30 0.86 (0.73–0.92) ↵a Significant difference with manual interobserver measurements.
50% κa (95% CI) 70% κb (95% CI) Manual intraobserver (n = 38) 0.73 (0.50–0.95) 0.53 (0.02–1) Manual interobserver (n = 37) 0.73 (0.52–0.95) 0.47 (0.03–0.90) 3mensio interobserver (n = 141) 0.88 (0.80–0.96) 0.86 (0.73–0.98) Philips interobserver (n = 141) 0.71 (0.60–0.83) 0.53 (0.30–0.77) TeraRecon interobserver (n = 141) 0.56 (0.41–0.71) 0.37 (0.08–0.66) Siemens Interobserver (n = 141) 0.67 (0.54–0.80) 0.63 (0.42–0.84)
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