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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleExtracranial Vascular

Phlebographic Study Does Not Show Differences Between Patients with MS and Control Subjects

M. Stefanini, S. Fabiano, F. Garaci, S. Marziali, A. Meschini, V. Cama, M. Fornari, S. Rossi, D. Centonze, R. Gandini, G. Simonetti and R. Floris
American Journal of Neuroradiology June 2014, 35 (6) 1174-1179; DOI: https://doi.org/10.3174/ajnr.A3816
M. Stefanini
aFrom the Departments of Diagnostic Imaging (M.S., S.F., F.G., S.M., A.M., V.C., M.F., R.F., R.G., G.S.)
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S. Fabiano
aFrom the Departments of Diagnostic Imaging (M.S., S.F., F.G., S.M., A.M., V.C., M.F., R.F., R.G., G.S.)
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F. Garaci
aFrom the Departments of Diagnostic Imaging (M.S., S.F., F.G., S.M., A.M., V.C., M.F., R.F., R.G., G.S.)
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S. Marziali
aFrom the Departments of Diagnostic Imaging (M.S., S.F., F.G., S.M., A.M., V.C., M.F., R.F., R.G., G.S.)
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A. Meschini
aFrom the Departments of Diagnostic Imaging (M.S., S.F., F.G., S.M., A.M., V.C., M.F., R.F., R.G., G.S.)
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V. Cama
aFrom the Departments of Diagnostic Imaging (M.S., S.F., F.G., S.M., A.M., V.C., M.F., R.F., R.G., G.S.)
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M. Fornari
aFrom the Departments of Diagnostic Imaging (M.S., S.F., F.G., S.M., A.M., V.C., M.F., R.F., R.G., G.S.)
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S. Rossi
bNeuroscience (S.R., D.C.), University of Rome Tor Vergata, Rome, Italy
cSanta Lucia Foundation/European Center for Brain Research (CERC) (S.R., D.C.), Rome, Italy.
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D. Centonze
bNeuroscience (S.R., D.C.), University of Rome Tor Vergata, Rome, Italy
cSanta Lucia Foundation/European Center for Brain Research (CERC) (S.R., D.C.), Rome, Italy.
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R. Gandini
aFrom the Departments of Diagnostic Imaging (M.S., S.F., F.G., S.M., A.M., V.C., M.F., R.F., R.G., G.S.)
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G. Simonetti
aFrom the Departments of Diagnostic Imaging (M.S., S.F., F.G., S.M., A.M., V.C., M.F., R.F., R.G., G.S.)
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R. Floris
aFrom the Departments of Diagnostic Imaging (M.S., S.F., F.G., S.M., A.M., V.C., M.F., R.F., R.G., G.S.)
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  • Fig 1.
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    Fig 1.

    Selective catheterization of the azygos vein in a 37-year-old patient with secondary-progressive MS in which the injection of contrast medium showed the presence of a twisting of the AV associated with a shunt with the hemiazygous venous system. Note the opacification of the intraspinal venous plexus.

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    Fig 2.

    Selective catheterization of the left and right internal jugular veins in a 35-year-old patient with relapsing-remitting MS. Venous stenosis at the level of the section J2 of the right IJV and of its origin is shown, with associated drainage in spinal venous plexus through a collateral branch. The left IJV does not present alterations in size and drainage.

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    Fig 3.

    Selective catheterization of the left internal jugular vein in a 41-year-old patient with primary-progressive MS. After injection of contrast medium, stenosis of segment J1 with reflux in both vertebral veins and opacification of the vertebral venous plexus is documented.

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    Fig 4.

    Selective catheterization of the ileo-lumbar plexus in a 33-year-old patient affected by relapsing-remitting MS. After injection of the contrast medium, opacification of the intraspinal venous plexus without opacification of the inferior vena cava is documented.

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    Fig 5.

    Selective catheterization of the azygos vein in a 45-year-old patient affected by relapsing-remitting MS. At the confluence of the azygos vein after administration of contrast medium, a valve is evident.

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    Fig 6.

    Selective catheterization of the internal jugular veins bilaterally (A, -B) in a 27-year-old control subject. Complete obstruction of the IJVs bilaterally with evidence of venous outflow through collateral circulation in the external jugular veins is shown.

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    Table 1:

    Demographic and clinical characteristics

    Study GroupControl GroupP Value
    No.2915
    Sex, M/F10/1911/4.03
    Age, y46.4 ± 9.542.6 ± 7.1.18
    Disease duration, y12.6 ± 6.7NA
    Disease course (RR/SP/PP)17/8/4NA
    EDSS3.6 ± 2.1 (1.0–7.0)NA
    • Note:—NA indicates not applicable; RR, relapsing-remitting; SP, secondary-progressive; PP, primary-progressive.

    • View popup
    Table 2:

    Logistic regression (MS condition as outcome variable)

    CoefficientSEOR95% CIP Value
    Venography0.771.242.160.18–24.91.53
    Stenosis, n−0.010.590.980.30–3.19.98
    Age0.060.041.060.97–1.15.16
    Sex, male−1.570.720.200.05–0.86.03
    • Note:—SE indicates standard error.

    • View popup
    Table 3:

    Venographic pattern distribution

    TypeStudy GroupControl GroupRR MSSP MSPP MS
    A42310
    B10010
    C104811
    D10010
    • Note:—RR indicates relapsing-remitting; SP, secondary-progressive; PP, primary-progressive.

    • View popup
    Table 4:

    Logistic regression (progressive MS as outcome variable)

    CoefficientSEOR95% CIP Value
    Venography−2.261.600.100.00–2.38.15
    Stenosis, n0.760.762.140.48–9.56.31
    Age0.100.051.121.00–1.24.04
    Sex, male0.830.922.290.37–14.19.37
    • Note:—SE indicates standard error.

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American Journal of Neuroradiology: 35 (6)
American Journal of Neuroradiology
Vol. 35, Issue 6
1 Jun 2014
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Cite this article
M. Stefanini, S. Fabiano, F. Garaci, S. Marziali, A. Meschini, V. Cama, M. Fornari, S. Rossi, D. Centonze, R. Gandini, G. Simonetti, R. Floris
Phlebographic Study Does Not Show Differences Between Patients with MS and Control Subjects
American Journal of Neuroradiology Jun 2014, 35 (6) 1174-1179; DOI: 10.3174/ajnr.A3816

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Phlebographic Study Does Not Show Differences Between Patients with MS and Control Subjects
M. Stefanini, S. Fabiano, F. Garaci, S. Marziali, A. Meschini, V. Cama, M. Fornari, S. Rossi, D. Centonze, R. Gandini, G. Simonetti, R. Floris
American Journal of Neuroradiology Jun 2014, 35 (6) 1174-1179; DOI: 10.3174/ajnr.A3816
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