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Research ArticleBrain
Open Access

Long-Term White Matter Changes after Severe Traumatic Brain Injury: A 5-Year Prospective Cohort

J. Dinkel, A. Drier, O. Khalilzadeh, V. Perlbarg, V. Czernecki, R. Gupta, F. Gomas, P. Sanchez, D. Dormont, D. Galanaud, R.D. Stevens, L. Puybasset and for NICER (Neuro Imaging for Coma Emergence and Recovery) Consortium
American Journal of Neuroradiology January 2014, 35 (1) 23-29; DOI: https://doi.org/10.3174/ajnr.A3616
J. Dinkel
aFrom the Department of Radiology (J.D., O.K., R.G.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
bDepartment of Radiology (J.D.), University Hospital Heidelberg, Heidelberg, Germany
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A. Drier
cDepartments of Neuroradiology (A.D., D.D., D.G.)
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O. Khalilzadeh
aFrom the Department of Radiology (J.D., O.K., R.G.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
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V. Perlbarg
fINSERM, UMRS 678 (V.P.)
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V. Czernecki
dNeurology (V.C.)
gINSERM, CRICM UMR S975 (V.C.), Université Pierre et Marie Curie-Paris 6, Paris, France
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R. Gupta
aFrom the Department of Radiology (J.D., O.K., R.G.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
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F. Gomas
hDepartment of Anesthesiology and Intensive Care (F.G.), Louis Mourier Hospital, Colombes, France
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P. Sanchez
eAnesthesiology and Intensive Care (P.S., L.P.), Pitié Salpêtrière Hospital, Assistance Publique–Hôpitaux de Paris, France
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D. Dormont
cDepartments of Neuroradiology (A.D., D.D., D.G.)
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D. Galanaud
cDepartments of Neuroradiology (A.D., D.D., D.G.)
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R.D. Stevens
iDivision of Neuroscience Critical Care (R.D.S.), Department of Anesthesiology Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
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L. Puybasset
eAnesthesiology and Intensive Care (P.S., L.P.), Pitié Salpêtrière Hospital, Assistance Publique–Hôpitaux de Paris, France
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REFERENCES

  1. 1.↵
    1. Saatman KE,
    2. Duhaime AC,
    3. Bullock R,
    4. et al
    . Classification of traumatic brain injury for targeted therapies. J Neurotrauma 2008;25:719–38
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. Narayan RK,
    2. Michel ME,
    3. Ansell B,
    4. et al
    . Clinical trials in head injury. J Neurotrauma 2002;19:503–57
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Smith DH,
    2. Meaney DF,
    3. Shull WH
    . Diffuse axonal injury in head trauma. J Head Trauma Rehabil 2003;18:307–16
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Wada T,
    2. Asano Y,
    3. Shinoda J
    . Decreased fractional anisotropy evaluated using tract-based spatial statistics and correlated with cognitive dysfunction in patients with mild traumatic brain injury in the chronic stage. AJNR Am J Neuroradiol 2012;33:2117–22
    Abstract/FREE Full Text
  5. 5.↵
    1. Basser PJ,
    2. Mattiello J,
    3. LeBihan D
    . MR diffusion tensor spectroscopy and imaging. Biophys J 1994;66:259–67
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. Kraus MF,
    2. Susmaras T,
    3. Caughlin BP,
    4. et al
    . White matter integrity and cognition in chronic traumatic brain injury: a diffusion tensor imaging study. Brain 2007;130:2508–19
    Abstract/FREE Full Text
  7. 7.↵
    1. Kumar R,
    2. Husain M,
    3. Gupta RK,
    4. et al
    . Serial changes in the white matter diffusion tensor imaging metrics in moderate traumatic brain injury and correlation with neuro-cognitive function. J Neurotrauma 2009;26:481–95
    CrossRefPubMedWeb of Science
  8. 8.↵
    1. Ewing-Cobbs L,
    2. Prasad MR,
    3. Swank P,
    4. et al
    . Arrested development and disrupted callosal microstructure following pediatric traumatic brain injury: relation to neurobehavioral outcomes. Neuroimage 2008;42:1305–15
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. Akpinar E,
    2. Koroglu M,
    3. Ptak T
    . Diffusion tensor MR imaging in pediatric head trauma. J Comput Assist Tomogr 2007;31:657–61
    CrossRefPubMedWeb of Science
  10. 10.↵
    1. Wilde EA,
    2. Chu Z,
    3. Bigler ED,
    4. et al
    . Diffusion tensor imaging in the corpus callosum in children after moderate to severe traumatic brain injury. J Neurotrauma 2006;23:1412–26
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Wilde EA,
    2. McCauley SR,
    3. Hunter JV,
    4. et al
    . Diffusion tensor imaging of acute mild traumatic brain injury in adolescents. Neurology 2008;70:948–55
    CrossRef
  12. 12.↵
    1. Lipton ML,
    2. Kim N,
    3. Park YK,
    4. et al
    . Robust detection of traumatic axonal injury in individual mild traumatic brain injury patients: intersubject variation, change over time and bidirectional changes in anisotropy. Brain Imaging Behav 2012;6:329–42
    CrossRefPubMed
  13. 13.↵
    1. Betz J,
    2. Zhuo J,
    3. Roy A,
    4. et al
    . Prognostic value of diffusion tensor imaging parameters in severe traumatic brain injury. J Neurotrauma 2012;29:1292–305
    CrossRefPubMed
  14. 14.↵
    1. Newcombe V,
    2. Chatfield D,
    3. Outtrim J,
    4. et al
    . Mapping traumatic axonal injury using diffusion tensor imaging: correlations with functional outcome. PLoS One 2011;6:e19214
    CrossRefPubMed
  15. 15.↵
    1. Yuan W,
    2. Holland SK,
    3. Schmithorst VJ,
    4. et al
    . Diffusion tensor MR imaging reveals persistent white matter alteration after traumatic brain injury experienced during early childhood. AJNR Am J Neuroradiol 2007;28:1919–25
    Abstract/FREE Full Text
  16. 16.↵
    1. Levin HS
    . Neuroplasticity following non-penetrating traumatic brain injury. Brain Inj 2003;17:665–74
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. Wu TC,
    2. Wilde EA,
    3. Bigler ED,
    4. et al
    . Longitudinal changes in the corpus callosum following pediatric traumatic brain injury. Dev Neurosci 2010;32:361–73
    PubMed
  18. 18.↵
    1. Young JA,
    2. Tolentino M
    . Neuroplasticity and its applications for rehabilitation. Am J Ther 2011;18:70–80
    CrossRefPubMed
  19. 19.↵
    1. Galanaud D,
    2. Perlbarg V,
    3. Gupta R,
    4. et al
    . Assessment of white matter injury and outcome in severe brain trauma: a prospective multicenter cohort. Anesthesiology 2012;117:1300–10
    CrossRefPubMed
  20. 20.↵
    1. Smith SM,
    2. Jenkinson M,
    3. Woolrich MW,
    4. et al
    . Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage 2004;23 Suppl 1:S208–19
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Pierpaoli C,
    2. Basser PJ
    . Toward a quantitative assessment of diffusion anisotropy. Magn Reson Med 1996;36:893–906
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Smith SM,
    2. Jenkinson M,
    3. Johansen-Berg H,
    4. et al
    . Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage 2006;31:1487–505
    CrossRefPubMedWeb of Science
  23. 23.↵
    1. Mori S,
    2. Wakana S,
    3. Nagae-Poetscher L,
    4. et al
    . MRI Atlas of Human White Matter. Amsterdam: Elsevier; 2005
  24. 24.↵
    1. Luyt CE,
    2. Galanaud D,
    3. Perlbarg V,
    4. et al
    . Diffusion tensor imaging to predict long-term outcome after cardiac arrest: a bicentric pilot study. Anesthesiology 2012;117:1311–21
    CrossRefPubMed
  25. 25.↵
    1. Benjamini Y,
    2. Hochberg Y
    . Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Royal Stat Soc Ser B 1995;57:289–300
  26. 26.↵
    1. Sidaros A,
    2. Engberg AW,
    3. Sidaros K,
    4. et al
    . Diffusion tensor imaging during recovery from severe traumatic brain injury and relation to clinical outcome: a longitudinal study. Brain 2008;131:559–72
    Abstract/FREE Full Text
  27. 27.↵
    1. Mac Donald CL,
    2. Dikranian K,
    3. Bayly P,
    4. et al
    . Diffusion tensor imaging reliably detects experimental traumatic axonal injury and indicates approximate time of injury. J Neurosci 2007;27:11869–76
    Abstract/FREE Full Text
  28. 28.↵
    1. Huisman TA,
    2. Schwamm LH,
    3. Schaefer PW,
    4. et al
    . Diffusion tensor imaging as potential biomarker of white matter injury in diffuse axonal injury. AJNR Am J Neuroradiol 2004;25:370–76
    Abstract/FREE Full Text
  29. 29.↵
    1. Farbota KD,
    2. Bendlin BB,
    3. Alexander AL,
    4. et al
    . Longitudinal diffusion tensor imaging and neuropsychological correlates in traumatic brain injury patients. Front Hum Neurosci 2012;6:160
    PubMed
  30. 30.↵
    1. Parvizi J,
    2. Damasio AR
    . Neuroanatomical correlates of brainstem coma. Brain 2003;126:1524–36
    Abstract/FREE Full Text
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J. Dinkel, A. Drier, O. Khalilzadeh, V. Perlbarg, V. Czernecki, R. Gupta, F. Gomas, P. Sanchez, D. Dormont, D. Galanaud, R.D. Stevens, L. Puybasset, for NICER (Neuro Imaging for Coma Emergence and Recovery) Consortium
Long-Term White Matter Changes after Severe Traumatic Brain Injury: A 5-Year Prospective Cohort
American Journal of Neuroradiology Jan 2014, 35 (1) 23-29; DOI: 10.3174/ajnr.A3616

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Long-Term White Matter Changes after Severe Traumatic Brain Injury: A 5-Year Prospective Cohort
J. Dinkel, A. Drier, O. Khalilzadeh, V. Perlbarg, V. Czernecki, R. Gupta, F. Gomas, P. Sanchez, D. Dormont, D. Galanaud, R.D. Stevens, L. Puybasset, for NICER (Neuro Imaging for Coma Emergence and Recovery) Consortium
American Journal of Neuroradiology Jan 2014, 35 (1) 23-29; DOI: 10.3174/ajnr.A3616
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