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Research ArticleSpine

PET Findings of Intramedullary Tumors of the Spinal Cord Using [18F] FDG and [11C] Methionine

N. Tomura, Y. Ito, H. Matsuoka, T. Saginoya, S.-i. Numazawa, Y. Mizuno and K. Watanabe
American Journal of Neuroradiology June 2013, 34 (6) 1278-1283; DOI: https://doi.org/10.3174/ajnr.A3374
N. Tomura
aFrom the Departments of Radiology (N.T., T.S., Y.M.)
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Y. Ito
bNeurosurgery (Y.I., H.M., S.-i.N., K.W.), Southern Tohoku Research Institute for Neuroscience, Southern Tohoku General Hospital, Fukushima, Japan.
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H. Matsuoka
bNeurosurgery (Y.I., H.M., S.-i.N., K.W.), Southern Tohoku Research Institute for Neuroscience, Southern Tohoku General Hospital, Fukushima, Japan.
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T. Saginoya
aFrom the Departments of Radiology (N.T., T.S., Y.M.)
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S.-i. Numazawa
bNeurosurgery (Y.I., H.M., S.-i.N., K.W.), Southern Tohoku Research Institute for Neuroscience, Southern Tohoku General Hospital, Fukushima, Japan.
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Y. Mizuno
aFrom the Departments of Radiology (N.T., T.S., Y.M.)
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K. Watanabe
bNeurosurgery (Y.I., H.M., S.-i.N., K.W.), Southern Tohoku Research Institute for Neuroscience, Southern Tohoku General Hospital, Fukushima, Japan.
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    Fig 1.

    A 23-year-old woman with an anaplastic astrocytoma. T2-weighted MR image (A) reveals a tumor of the spinal cord from the eighth thoracic vertebra to the first lumbar vertebra (white arrows). A contrast-enhanced T1-weighted MR image with fat saturation (B) shows mild contrast enhancement of the tumor (white arrows). FDG-PET (C) and MET-PET (D) reveal increased activity of both FDG (SUVmax = 7.4) and MET (SUVmax = 3.2) of the tumor (white arrows). A fusion image of FDG-PET and contrast-enhanced T1-weighted MR imaging with fat saturation (E) clearly shows increased uptake of FDG in the tumor.

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    Fig 2.

    A 56-year-old man with an ependymoma. A contrast-enhanced T1-weighted image (A) shows a tumor from the first to fifth cervical vertebra with a cystic and solid component (white arrows). Contrast enhancement of the solid component at the second cervical vertebra is seen (white arrows). FDG-PET (B) and MET-PET (C) show accumulation of both FDG (SUVmax = 11.2) and MET (SUVmax = 2.2) (white arrows).

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    Fig 3.

    A 12-year-old girl with a cavernous angioma. A T2-weighted MR image (A) shows a mainly hypointense tumor (white arrows) at the twelfth thoracic vertebra. Hypointensity may be due to hemosiderin deposition. A hyperintense area surrounding the hypointense lesion seems to be edema, but its histologic evidence was not acquired. Although accumulation of MET is not evident (B), FDG-PET (C) shows slight activity of the tumor (SUVmax = 5.2) (black arrow).

Tables

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  • SUVmax of each tumor

    PatientAge (yr)SexPathologyLocationCystic ComponentSUVmax (FDG)SUVmax (MET)
    123FAnaplastic astrocytomaTh–7.43.2
    247MHemangioblastomaL+2.52.4
    318FEpendymomaC+102.9
    456MEpendymomaC+11.22.2
    530MEpendymoma (myxopapillary)L+2.42.2
    641MEpendymoma (tanycytic)Th–5.42.4
    712FCavernous angiomaTh–5.22.0
    875FEpendymoma (cellular)C+7.13.5
    929FEpendymoma (myxopapillary)L+3.53.2
    • Note:—Th indicates thoracic cord; L, lumbar cord; C, cervical cord; –, absence of cystic component on MRI; +, existence of cystic component on MRI.

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American Journal of Neuroradiology: 34 (6)
American Journal of Neuroradiology
Vol. 34, Issue 6
1 Jun 2013
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N. Tomura, Y. Ito, H. Matsuoka, T. Saginoya, S.-i. Numazawa, Y. Mizuno, K. Watanabe
PET Findings of Intramedullary Tumors of the Spinal Cord Using [18F] FDG and [11C] Methionine
American Journal of Neuroradiology Jun 2013, 34 (6) 1278-1283; DOI: 10.3174/ajnr.A3374

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PET Findings of Intramedullary Tumors of the Spinal Cord Using [18F] FDG and [11C] Methionine
N. Tomura, Y. Ito, H. Matsuoka, T. Saginoya, S.-i. Numazawa, Y. Mizuno, K. Watanabe
American Journal of Neuroradiology Jun 2013, 34 (6) 1278-1283; DOI: 10.3174/ajnr.A3374
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