Article Figures & Data
Figures
- Fig 1.
Characteristics of Eagle Eye Gold IVUS imaging catheter.
- Fig 2.
Histopathologic sections with corresponding VH-IVUS images. A and B, Fibrous (arrows in A) and fibrofatty (arrowheads in A) tissues in the histologic section are correlated with dark green and light green areas in VH-IVUS, respectively. C and D, attenuated calcium and necrotic area (arrows in C) and its corresponding area in VH-IVUS red (necrosis) and white (attenuated calcium) areas.
- Fig 3.
Four different histopathologic sections of intracranial vessels with atherosclerotic plaque and their corresponding 3D SPACE MR imaging (in the middle) and VH-IVUS (on the right) images. Fibrous areas (arrows) and attenuated calcium (arrowheads) consistently visualized as areas with hyperintense and hypointense signals in MR imaging, respectively.
Tables
- Table 1:
Comparison of different types of atherosclerotic plaques between VH-IVUS and histologic sections (as reference standard)
Category of Plaque Plaque Classification by Histological Analysis Plaque Classification by VH-IVUS Analysis True-Positive True-Negative False-Positive False-Negative Sensitivity Specificity PPV NPV No plaque 2 2 32 0 0 100 100 100 100 Pathologic intima thickening 6 3 28 0 3 50 100 100 90.3 Fibroatheroma 19 15 11 4 4 78.9 73.3 78.9 73.3 Calcified fibroatheromaa 0 0 33 1 0 0 97 0 100 Thin-cap fibroatheroma 3 2 30 1 1 66.6 96.7 66.6 96.7 Calcified thin-cap fibroatheroma 2 1 31 1 1 50 96.8 50 96.8 Fibrocalcific atheroma 2 2 32 0 0 100 100 100 100 Total 34 25 197 7 9 73.5 96.6 78.1 95.6 PPV indicates positive predictive value; NPV, negative predictive value.
↵a Number is small and requires cautious interpretation of false-positive or false-negative values.
- Table 2:
Area of 4 different components of plaque types in histologic sections and VH-IVUS analyses
Histopathology, % (SD) VH-IVUS, % (SD) Pearson Correlation Fibrous 45.6 (18.7) 50.8 (17.1) 0.66 Fibrofatty 35.6 (14.1) 12.5 (12.1) 0.34 Dense calcium 7.1 (7.6) 9.1 (5.2) 0.64 Necrosis 5.1 (4.6) 20.9 (10.9) 0.23
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