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Improved Turnaround Times | Median time to first decision: 12 days

Research ArticleNeurointervention

C-Arm CT Measurement of Cerebral Blood Volume Using Intra-Arterial Injection of Contrast Medium: An Experimental Study in Canines

R. Yasuda, K. Royalty, K. Pulfer, D. Consigny and C.M. Strother
American Journal of Neuroradiology October 2012, 33 (9) 1696-1701; DOI: https://doi.org/10.3174/ajnr.A3077
R. Yasuda
aFrom the Department of Neurosurgery, Mie University Graduate School of Medicine (R.Y.), Tsu, Mie, Japan
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K. Royalty
bSiemens Medical Solutions (K.R.), Hoffman Estates, Illinois
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K. Pulfer
cDepartment of Radiology, University of Wisconsin School of Medicine and Public Health (K.P., D.C., C.M.S.), Madison, Wisconsin.
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D. Consigny
cDepartment of Radiology, University of Wisconsin School of Medicine and Public Health (K.P., D.C., C.M.S.), Madison, Wisconsin.
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C.M. Strother
cDepartment of Radiology, University of Wisconsin School of Medicine and Public Health (K.P., D.C., C.M.S.), Madison, Wisconsin.
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    Fig 1.

    Bland-Altman plots. Modalities compared are shown at the top of each plot.

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    Fig 2.

    Scatterplots comparing injection sites and CBV values in normal and abnormal hemispheres in 2 normal animals and in 2 with ischemia. Analysis was not completed for the VA and CCA injections in the animals with a stroke. Each color depicts a different region of interest/section combination type (see key). The upper panel title contains the dog number and stroke laterality, and the lower panel title contains the type of CT injection. Line segments reflect pairing of ROIs across hemispheres. The left column is from dog #8, the second column from the left is from dog #10, the third column from the left is from dog #9, and the right column is from dog #11. Because dog #8 had a stroke, analysis for C-arm VA injection was not performed in this dog.

Tables

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    Table 1:

    Injection protocols

    ModalityContrastSaline ChaseTotal Injection Volume (ml)
    Concentration (%)Volume (ml)Injection Rate (ml/s)Volume (ml)Injection Rate (ml/s)
    PCT100121.0101.522
    C-arm IV100251.0101.035
    C-arm AA15–2011.25–154.0–75
    C-arm CCA10–304.3–152.5–43–50
    C-arm VA10–303–9.91.5–2.5–30–33
    • View popup
    Table 2:

    Dogs and C-arm injections performed

    Dog #Stroke CreationC-Arm Injection Sites
    1NormalCCA(L), VA
    2LCCA(L), VA, IV
    3NormalCCA(L), VA
    4L, RAA, IV, VA, CCA(R)
    5RVA, IV
    6LAA, IV, VA, CCA(R)
    7L, RAA, IV, VA
    8LAA, IV, VA
    9NormalCCA(L), CCA(R), VA, IV
    10RAA, IV
    11NormalCCA(L), CCA(R), VA
    12L, RAA, IV
    • Note:—PCT was performed in all dogs.

    • L indicates left; R, right.

    • View popup
    Table 3:

    Observer performance in evaluating CBV maps from PCT and C-arm studies

    PCTC-Arm IVC-Arm AAC-Arm CCAC-Arm VA
    Observer 1
        True-positive8762
        False-positive
        False-negative123
        True-negative4174
    Observer 2
        True-positive8853
        False-positive
        False-negative122
        True-negative4174
    • View popup
    Table 4:

    Mean CBV values in each modality

    ModalityNormal HemisphereStroke HemisphereP valuea
    PCT2.38 ± 0.54 (n = 14)1.01 ± 0.85 (n = 10)<0.001
    C-arm IV2.33 ± 0.67 (n = 8)1.00 ± 0.76 (n = 10)<0.001
    C-arm AA2.47 ± 0.76 (n = 4)1.02 ± 0.93 (n = 8)<0.001
    C-arm CCA2.40 ± 0.73 (n = 7)––
    C-arm VA2.23 ± 1.21 (n = 10)––
    • ↵a General estimating equation model. The numbers in the parentheses represent hemispheres studied.

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    Table 5:

    Bland-Altman analysis

    Bias (SD)95% Limits of Agreement
    LowerUpper
    PCT vs C-arm IV−0.031 (0.447)−1.2181.155
    PCT vs C-arm AA−0.092 (0.605)−1.6301.446
    PCT vs C-arm CCA0.048 (0.912)−2.0552.153
    PCT vs C-arm VA0.180 (1.463)−3.1053.465
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American Journal of Neuroradiology: 33 (9)
American Journal of Neuroradiology
Vol. 33, Issue 9
1 Oct 2012
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Cite this article
R. Yasuda, K. Royalty, K. Pulfer, D. Consigny, C.M. Strother
C-Arm CT Measurement of Cerebral Blood Volume Using Intra-Arterial Injection of Contrast Medium: An Experimental Study in Canines
American Journal of Neuroradiology Oct 2012, 33 (9) 1696-1701; DOI: 10.3174/ajnr.A3077

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C-Arm CT Measurement of Cerebral Blood Volume Using Intra-Arterial Injection of Contrast Medium: An Experimental Study in Canines
R. Yasuda, K. Royalty, K. Pulfer, D. Consigny, C.M. Strother
American Journal of Neuroradiology Oct 2012, 33 (9) 1696-1701; DOI: 10.3174/ajnr.A3077
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