C-Arm CT Measurement of Cerebral Blood Volume Using Intra-Arterial Injection of Contrast Medium: An Experimental Study in Canines

Article Figures & Data

Download figure
Open in new tab
Download powerpoint
Fig 1.
Bland-Altman plots. Modalities compared are shown at the top of each plot.
Download figure
Open in new tab
Download powerpoint
Fig 2.
Scatterplots comparing injection sites and CBV values in normal and abnormal hemispheres in 2 normal animals and in 2 with ischemia. Analysis was not completed for the VA and CCA injections in the animals with a stroke. Each color depicts a different region of interest/section combination type (see key). The upper panel title contains the dog number and stroke laterality, and the lower panel title contains the type of CT injection. Line segments reflect pairing of ROIs across hemispheres. The left column is from dog #8, the second column from the left is from dog #10, the third column from the left is from dog #9, and the right column is from dog #11. Because dog #8 had a stroke, analysis for C-arm VA injection was not performed in this dog.

Table 1:

Injection protocols

Modality	Contrast			Saline Chase			Total Injection Volume (ml)
Modality	Concentration (%)	Volume (ml)	Injection Rate (ml/s)	Volume (ml)		Injection Rate (ml/s)	Total Injection Volume (ml)
PCT	100	12	1.0	10		1.5	22
C-arm IV	100	25	1.0	10		1.0	35
C-arm AA	15–20	11.25–15	4.0		–		75
C-arm CCA	10–30	4.3–15	2.5		–		43–50
C-arm VA	10–30	3–9.9	1.5–2.5		–		30–33

Table 2:

Dogs and C-arm injections performed

Table 3:

Observer performance in evaluating CBV maps from PCT and C-arm studies

	PCT	C-Arm IV	C-Arm AA	C-Arm CCA	C-Arm VA
Observer 1
True-positive	8	7	6		2
False-positive
False-negative		1		2	3
True-negative	4	1		7	4
Observer 2
True-positive	8	8	5		3
False-positive
False-negative			1	2	2
True-negative	4	1		7	4

Table 4:

Mean CBV values in each modality

Modality	Normal Hemisphere	Stroke Hemisphere	P value^a
PCT	2.38 ± 0.54 (n = 14)	1.01 ± 0.85 (n = 10)	<0.001
C-arm IV	2.33 ± 0.67 (n = 8)	1.00 ± 0.76 (n = 10)	<0.001
C-arm AA	2.47 ± 0.76 (n = 4)	1.02 ± 0.93 (n = 8)	<0.001
C-arm CCA	2.40 ± 0.73 (n = 7)	–	–
C-arm VA	2.23 ± 1.21 (n = 10)	–	–

↵a General estimating equation model. The numbers in the parentheses represent hemispheres studied.

Table 5:

Bland-Altman analysis