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Research ArticleNeurointervention

Endovascular Treatment of Ruptured Intracranial Aneurysms: Factors Affecting Midterm Quality Anatomic Results: Analysis in a Prospective, Multicenter Series of Patients (CLARITY)

L. Pierot, C. Cognard, R. Anxionnat and F. Ricolfi for the CLARITY Investigators
American Journal of Neuroradiology September 2012, 33 (8) 1475-1480; DOI: https://doi.org/10.3174/ajnr.A3003
L. Pierot
aFrom the Department of Neuroradiology (L.P.), Reims University, Reims, France
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C. Cognard
bDepartment of Neuroradiology (C.C.), Toulouse University, Toulouse, France
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R. Anxionnat
cDepartment of Neuroradiology (R.A.), Nancy University, Nancy, France
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F. Ricolfi
dDepartment of Radiology (F.R.), Dijon University, Dijon, France
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Article Figures & Data

Tables

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    Table 1:

    Adequate occlusion and aneurysm remnant at midterm follow-up relating to clinical factors and immediate postoperative aneurysm occlusion

    Adequate OcclusionAneurysm RemnantP Value
    No.% (95% CI)No.% (95% CI)
    SexFemale (314)25280.3 (75.4–84.5)6219.7 (15.5–24.6).569
    Male (203)16782.3 (76.3–87.3)3617.7 (12.7–23.7)
    Age<65 years (448)36781.9 (78.0–85.4)8118.1 (14.6–22.0).198
    ≥65 years (69)5275.4 (63.5–85.0)1724.6 (15.1–36.5)
    HypertensionYes (145)10874.5 (66.6–81.4)3725.5 (18.6–33.4).018
    No (372)31183.6 (79.4–87.2)6116.4 (12.8–20.6)
    SmokingYes (225)18280.9 (75.1–85.8)4319.1 (14.2–24.9).937
    No (292)23781.2 (76.2–85.5)5518.8 (14.5–23.8)
    WFNS≤2 (391)31680.8 (76.6–84.6)7519.2 (15.4–23.5).817
    >2 (126)10381.7 (73.9–88.1)2318.3 (11.9–26.1)
    Postop. aneurysm occlusionAO (463)39585.3 (81.8–88.4)6814.7 (11.6–18.3)<.001
    AR (54)2444.4 (30.9–58.6)3055.6 (41.4–69.1)
    • Note:—CI indicates confidence interval; postop., postoperative.

    • View popup
    Table 2:

    Adequate occlusion and aneurysm remnant at midterm follow-up relating to anatomic and therapeutic factors

    Adequate OcclusionAneurysm RemnantP Value
    No.% (95% CI)No.% (95% CI)
    LocationICA (143)10875.5 (67.6–82.3)3524.5 (17.7–32.4).049
    ACA/AcomA (262)22084.0 (79.0–88.2)4216.0 (11.8–21.1).087
    MCA (68)5377.9 (66.2–87.1)1522.1 (12.9–33.8).484
    VB (44)3886.4 (72.6–94.8)613.6 (5.2–27.4).350
    Aneurysm size≤10 (470)38882.6 (78.8–85.9)8217.4 (14.1–21.2).007
    >10 (47)3166.0 (50.7–79.1)1634.0 (20.9–49.3)
    Neck size≤4 (451)37482.9 (79.1–86.3)7717.1 (13.7–20.9).005
    >4 (66)4568.2 (56.6–79.1)2131.8 (20.9–44.4)
    Dome-to-neck≤1.5 (216)17380.1 (74.1–85.2)4319.9 (14.8–25.9).640
    >1.5 (301)24681.7 (76.9–85.9)5518.3 (14.1–23.1)
    Type of treatmentCoiling (407)32579.9 (75.6–83.7)8220.1 (16.4–24.4).186
    Remodeling (110)9485.5 (77.5–91.5)1614.5 (8.5–22.6)
    Type of coilsGDC (276)22481.2 (76.0–85.6)5218.8 (14.4–24.0).943
    Matrix (241)19580.9 (75.4–85.7)4619.1 (14.3–24.6)
    • Note:—CI indicates confidence interval.

    • View popup
    Table 3:

    Evolution of aneurysm occlusion relating to clinical factors and immediate postoperative aneurysm occlusion

    Stable or ImprovedWorsenedP Value
    No% (95% CI)No% (95% CI)
    SexFemale (311)15951.1 (45.4–56.8)15248.9 (43.2–54.6).426
    Male (202)9647.5 (40.5–54.7)10652.5 (45.3–59.5)
    Age<65 years (446)21347.8 (43.0–52.5)23352.2 (47.5–57.0).024
    ≥65 years (67)4262.7 (50.0–74.2)2537.3 (25.8–50.0)
    HypertensionYes (144)7451.4 (42.9–59.8)7048.6 (40.2–57.1).634
    No (369)18149.1 (43.8–54.3)18850.9 (45.7–56.2)
    SmokingYes (225)10948.4 (41.8–55.2)11651.6 (44.8–58.3).613
    No (288)14650.7 (44.8–56.6)14249.3 (43.4–55.2)
    WFNS≤2 (390)18948.5 (43.4–53.6)20151.5 (46.5–56.6).315
    >2 (123)6653.6 (44.4–62.7)5746.3 (37.3–55.6)
    Postop. aneurysm occlusionAO (460)23150.2 (45.6–54.9)22949.8 (45.1–54.5).497
    AR (53)2445.3 (31.6–59.6)2954.7 (40.4–68.4)
    • Note:—AO indicates adequate occlusion; AR, aneurysm remnant; CI, confidence interval; postop., postoperative

    • View popup
    Table 4:

    Evolution of aneurysm occlusion relating to anatomic and therapeutic factors

    Stable or ImprovedWorsenedP Value
    No% (95% CI)No% (95% CI)
    LocationICA (142)6344.4 (36.0–52.9)7955.6 (47.1–64.0).135
    ACA/AcomA (259)13150.6 (44.3–56.8)12849.4 (43.2–55.7).690
    MCA (68)3957.4 (44.8–69.3)2942.6 (30.7–55.2).177
    VB (44)2250.0 (34.6–65.4)2250.0 (34.6–65.4).968
    Aneurysm size≤10 (467)23650.5 (45.9–55.2)23149.5 (44.8–54.1).234
    >10 (46)1941.3 (27.0–56.8)2758.7 (43.2–73.0)
    Neck size≤4 (447)23051.5 (46.7–56.2)21748.5 (43.8–53.3).041
    >4 (66)2537.9 (26.1–50.7)4162.1 (49.3–73.8)
    Dome-to-neck≤1.5 (215)10749.8 (42.9–56.7)10850.2 (43.3–57.1).982
    >1.5 (298)14849.7 (43.8–55.5)15050.3 (44.5–56.2)
    Type of treatmentCoiling (404)20350.2 (45.3–55.2)20149.8 (44.8–54.7).638
    Remodeling (109)5247.7 (38.1–57.5)5752.3 (42.5–62.0)
    Type of coilsGDC (272)13348.9 (42.8–55.0)13951.1 (45.0–57.2).696
    Matrix (241)12250.6 (44.1–57.1)11949.4 (42.9–55.9)
    • Note:—CI, confidence interval.

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American Journal of Neuroradiology: 33 (8)
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L. Pierot, C. Cognard, R. Anxionnat, F. Ricolfi
Endovascular Treatment of Ruptured Intracranial Aneurysms: Factors Affecting Midterm Quality Anatomic Results: Analysis in a Prospective, Multicenter Series of Patients (CLARITY)
American Journal of Neuroradiology Sep 2012, 33 (8) 1475-1480; DOI: 10.3174/ajnr.A3003

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Endovascular Treatment of Ruptured Intracranial Aneurysms: Factors Affecting Midterm Quality Anatomic Results: Analysis in a Prospective, Multicenter Series of Patients (CLARITY)
L. Pierot, C. Cognard, R. Anxionnat, F. Ricolfi
American Journal of Neuroradiology Sep 2012, 33 (8) 1475-1480; DOI: 10.3174/ajnr.A3003
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