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Research ArticleSpine
Open Access

Reduced-Distortion Diffusion MRI of the Craniovertebral Junction

M. Iima, A. Yamamoto, V. Brion, T. Okada, M. Kanagaki, K. Togashi and D. Le Bihan
American Journal of Neuroradiology August 2012, 33 (7) 1321-1325; DOI: https://doi.org/10.3174/ajnr.A2969
M. Iima
aFrom the Department of Diagnostic Imaging and Nuclear Medicine (M.I., A.Y., T.O., M.K., K.T.) and Human Brain Research Center (D.L.), Kyoto University Graduate School of Medicine, Kyoto, Japan
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A. Yamamoto
aFrom the Department of Diagnostic Imaging and Nuclear Medicine (M.I., A.Y., T.O., M.K., K.T.) and Human Brain Research Center (D.L.), Kyoto University Graduate School of Medicine, Kyoto, Japan
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V. Brion
bNeurospin (V.B., D.L.), I2BM, CEA-Saclay, Gif-sur-Yvette, France.
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T. Okada
aFrom the Department of Diagnostic Imaging and Nuclear Medicine (M.I., A.Y., T.O., M.K., K.T.) and Human Brain Research Center (D.L.), Kyoto University Graduate School of Medicine, Kyoto, Japan
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M. Kanagaki
aFrom the Department of Diagnostic Imaging and Nuclear Medicine (M.I., A.Y., T.O., M.K., K.T.) and Human Brain Research Center (D.L.), Kyoto University Graduate School of Medicine, Kyoto, Japan
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K. Togashi
aFrom the Department of Diagnostic Imaging and Nuclear Medicine (M.I., A.Y., T.O., M.K., K.T.) and Human Brain Research Center (D.L.), Kyoto University Graduate School of Medicine, Kyoto, Japan
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D. Le Bihan
aFrom the Department of Diagnostic Imaging and Nuclear Medicine (M.I., A.Y., T.O., M.K., K.T.) and Human Brain Research Center (D.L.), Kyoto University Graduate School of Medicine, Kyoto, Japan
bNeurospin (V.B., D.L.), I2BM, CEA-Saclay, Gif-sur-Yvette, France.
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    Fig 1.

    40-year-old healthy male volunteer. Coronal MR images of brain obtained at the same level: A, T2-weighted image, (B) RS-EPI diffusion trace image, (C) RS-EPI color-coded fiber orientation map, (D) the fusion image of RS-EPI and T2-weighted image of left temporal lobe, (E) SS-EPI diffusion trace image, (F) SS-EPI color-coded fiber orientation map, (G) the fusion image of SS-EPI and T2-weighted image of left temporal lobe. The natural lateral contour of the left temporal lobe in the T2-weighted image (A) becomes prominently distorted in the SS-EPI image (E), but the convex shape manages to be preserved in the RS-EPI image (B). The decussation of the internal arcuate fibers is seen at the medulla level on the RS-EPI image (C, arrow), more clearly compared with the SS-EPI image (F, arrow). The distance between the contours of the left temporal base is 5.58 mm for RS-EPI (D), and 9.36 mm for SS-EPI (G).

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    Fig 2.

    A, Distortion measurements at the level of the temporal base. B, Distortion measurements at the level of the cerebellum. The absolute distances between the contours of the temporal base (A) and the cerebellum (B), visible on the diffusion trace images for RS-EPI and SS-EPI and the corresponding T2-weighted images, are shown. The amount of distortion is significantly reduced with RS-EPI compared with SS-EPI (P <.01).

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    Table 1:

    Distortion using a semiquantitative scale

    Scale (0–4)
    4Perfect contour continuation, preserving the contrast of both white and gray matter; convexity (of the cerebrum and cerebellum) is almost the same as that of T2-weighted image
    3Good contour continuation, preserving the contrast of both white and gray matter; convexity (of the cerebrum and cerebellum) is preserved but is less pronounced compared with that of T2-weighted image
    2Poor contour continuation; discontinuity can be seen in some parts; convexity is lost
    1Contour continuation is lost; concave contour is observed
    0Very concave (opposite of the natural convexity of cerebrum and cerebellum), with significant distortion
    • View popup
    Table 2:

    Delineation of fine structures using a semiquantitative scale

    Scale (0–4)
    4Excellent; very good color contrast and discriminates with surrounding structure
    3Relatively good; very good color contrast and discriminates with surrounding structure
    2Enough good contrast with surrounding structure
    1Subtle, faint contrast with surrounding structure
    0Colors at border area are mixed; impossible to make diagnosis
    • View popup
    Table 3:

    The result of mean scales of RS-EPI and SS-EPI (distortion)

    RS-EPISS-EPIP Value
    Contours of temporal base
        Lateral2.2 ± 0.50.4 ± 0.5<0.01
        Inferior1.7 ± 0.60.0 ± 0.0<0.01
    Parietal lobe3.9 ± 0.23.7 ± 0.30.14
    Cerebellum
        Lateral2.6 ± 0.80.4 ± 0.3<0.01
        Inferior2.7 ± 0.70.6 ± 0.4<0.01
    Brain stem
        Center3.4 ± 0.52.2 ± 0.9<0.01
        Margin3.7 ± 0.33.0 ± 0.70.06
    Trigeminal nerve3.0 ± 0.71.8 ± 0.8<0.01
    Acoustic nerve2.3 ± 0.61.1 ± 0.6<0.01
    • View popup
    Table 4:

    The result of mean scales of RS-EPI and SS-EPI (delineation of fine structure)

    RS-EPISS-EPIP Value
    Cerebellar vermis3.4 ± 0.52.2 ± 0.7<0.05
    Temporal gyrus3.3 ± 0.41.2 ± 0.8<0.01
    Decussation of the internal arcuate fibers3.3 ± 0.91.6 ± 0.8<0.01
    Cerebellar peduncle
        Superior4.0 ± 0.03.9 ± 0.30.34
        Middle3.6 ± 0.32.8 ± 0.70.06
    Cerebral fornix4.0 ± 0.13.7 ± 0.60.24
    Laterality of basal ganglia3.6 ± 0.32.8 ± 0.6<0.05
    Brain stem3.4 ± 0.62.5 ± 0.70.07
    Pyramidal tract3.7 ± 0.33.2 ± 0.50.06
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American Journal of Neuroradiology: 33 (7)
American Journal of Neuroradiology
Vol. 33, Issue 7
1 Aug 2012
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Cite this article
M. Iima, A. Yamamoto, V. Brion, T. Okada, M. Kanagaki, K. Togashi, D. Le Bihan
Reduced-Distortion Diffusion MRI of the Craniovertebral Junction
American Journal of Neuroradiology Aug 2012, 33 (7) 1321-1325; DOI: 10.3174/ajnr.A2969

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Reduced-Distortion Diffusion MRI of the Craniovertebral Junction
M. Iima, A. Yamamoto, V. Brion, T. Okada, M. Kanagaki, K. Togashi, D. Le Bihan
American Journal of Neuroradiology Aug 2012, 33 (7) 1321-1325; DOI: 10.3174/ajnr.A2969
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