Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleNeurointervention
Open Access

Quantitative Characterization of the Hemodynamic Environment in Ruptured and Unruptured Brain Aneurysms

J.R. Cebral, F. Mut, J. Weir and C. Putman
American Journal of Neuroradiology January 2011, 32 (1) 145-151; DOI: https://doi.org/10.3174/ajnr.A2419
J.R. Cebral
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
F. Mut
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J. Weir
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
C. Putman
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • Fig 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 1.

    Subdivision of the volumetric vascular domain and its surface into geographic regions: aneurysm, near-parent vessel, far-parent vessel, and ostium surface.

  • Fig 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 2.

    Hemodynamic data reduction. Top row, left to right: aneurysm neck delineation, aneurysm orifice triangulation, and vascular model geographic subdivision. Middle row: flow visualization, left to right: flow streamlines, isovelocity surface, WSS distribution. Bottom row, left to right: normal velocity magnitude at the aneurysm orifice; inflow (red) and outflow (blue) regions of the ostium; and regions of high (red), normal (gray), and low (blue) WSS.

  • Fig 3.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 3.

    Ratio of mean hemodynamic variables of ruptured aneurysms to unruptured aneurysms for each flow condition considered. The green bars represent the mean values over the unruptured aneurysm group used as reference values (ie, normalized to 1). The asterisks indicate that the differences in mean values between ruptured and unruptured groups are statistically significant (for all flow conditions).

Tables

  • Figures
    • View popup
    Table 1:

    Mean values of hemodynamic variables computed over the ruptured and unruptured groups for each of the flow conditions considereda

    Flow ConditionAneurysm GroupICIMWSS (dyne/cm2)SCIVDRKERLSALSI
    Pulsatile flow (HR = 60 bpm)Ruptured1.0123849.970.360.23260%0.26
    Unruptured0.662776.470.9510.17656%0.25
    P value.0035.0034.0154.0123.2226.3716.6630
    Pulsatile flow (HR = 100 bpm)Ruptured1.00154510.140.41560.25960%0.27
    Unruptured0.6514026.391.03210.19756%0.25
    P value.0034.0039.0073.0065.1836.4317.6837
    Steady flow, lowRuptured1.0312718.260.3990.2554%0.216
    Unruptured0.6821915.901.0810.1952%0.216
    P value.0029.0026.0490.0102.2410.0953.9800
    Steady flow, mediumRuptured1.0011879.880.3410.22660%0.26
    Unruptured0.6621306.360.9140.17056%0.25
    P value.0035.0026.0159.0174.2362.4621.7407
    Steady flow, highRuptured0.95110812.770.2360.16868%0.333
    Unruptured0.622747.520.5710.12963%0.308
    P value.0040.0037.0092.0105.3492.2357.5029
    • a The (2-tailed) P values indicate the statistical significance of the difference of the mean values between the ruptured and unruptured groups, computed using a Student t test.

    • View popup
    Table 2:

    Variability with flow conditions of average hemodynamic measures and ratios of ruptured to unruptured aneurysms

    VariableRupturedUnrupturedRatio
    ICI7.8%8.8%1.6%
    MWSS80.2%81.6%7.1%
    SCI35.3%21.5%17.5%
    VDR43.2%47.1%10.7%
    KER20.5%17.4%2.0%
    LSA20.5%17.4%3.7%
    LSI35.1%29.8%7.5%
  • Table 3:
  • Table 4:
  • Table 5:
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 32 (1)
American Journal of Neuroradiology
Vol. 32, Issue 1
1 Jan 2011
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Quantitative Characterization of the Hemodynamic Environment in Ruptured and Unruptured Brain Aneurysms
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
J.R. Cebral, F. Mut, J. Weir, C. Putman
Quantitative Characterization of the Hemodynamic Environment in Ruptured and Unruptured Brain Aneurysms
American Journal of Neuroradiology Jan 2011, 32 (1) 145-151; DOI: 10.3174/ajnr.A2419

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Quantitative Characterization of the Hemodynamic Environment in Ruptured and Unruptured Brain Aneurysms
J.R. Cebral, F. Mut, J. Weir, C. Putman
American Journal of Neuroradiology Jan 2011, 32 (1) 145-151; DOI: 10.3174/ajnr.A2419
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • Abbreviations
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Appendix
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • A practical strategy for data assimilation of cerebral intra-aneurysmal flows using a variational method with boundary control of velocity
  • Hemodynamic Characteristics in Ruptured and Unruptured Intracranial Aneurysms: A Prospective Cohort Study Utilizing the AneurysmFlow Tool
  • Non-contrast enhanced silent MR angiography to evaluate hemodynamics and morphology of unruptured intracranial aneurysms: a comparative computational fluid dynamics study
  • Evaluation of aneurysm rupture risk based upon flowrate-independent hemodynamic parameters: a multi-center pilot study
  • Geometric versus hemodynamic indexes for rupture-destined aneurysms: a retrospective cohort and a repeated-measures study
  • Evaluation of aneurysm rupture risk based upon flowrate-independent hemodynamic parameters: a multi-center pilot study
  • Fluid-structure interaction simulation of tissue degradation and its effects on intra-aneurysm hemodynamics
  • Geometric variations associated with posterior communicating artery aneurysms
  • Nature, content and shifts over time of the most impactful unruptured intracranial aneurysms articles: a bibliometric analysis
  • Comparing Morphology and Hemodynamics of Stable-versus-Growing and Grown Intracranial Aneurysms
  • Differences in Cerebral Aneurysm Rupture Rate According to Arterial Anatomies Depend on the Hemodynamic Environment
  • Local Hemodynamic Conditions Associated with Focal Changes in the Intracranial Aneurysm Wall
  • Towards the Clinical utility of CFD for assessment of intracranial aneurysm rupture - a systematic review and novel parameter-ranking tool
  • Identification of Hostile Hemodynamics and Geometries of Cerebral Aneurysms: A Case-Control Study
  • Vessel Wall Enhancement in Unruptured Intracranial Aneurysms: An Indicator for Higher Risk of Rupture? High-Resolution MR Imaging and Correlated Histologic Findings
  • China Intracranial Aneurysm Project (CIAP): protocol for a prospective cohort study of interventional treatment and craniotomy for unruptured aneurysms
  • Shared and Distinct Rupture Discriminants of Small and Large Intracranial Aneurysms
  • Nonsphericity Index and Size Ratio Identify Morphologic Differences between Growing and Stable Aneurysms in a Longitudinal Study of 93 Cases
  • Hemodynamic Characteristics of Ruptured and Unruptured Multiple Aneurysms at Mirror and Ipsilateral Locations
  • Angioarchitectures and Hemodynamic Characteristics of Posterior Communicating Artery Aneurysms and Their Association with Rupture Status
  • REPLY:
  • Differences in Hemodynamics and Rupture Rate of Aneurysms at the Bifurcation of the Basilar and Internal Carotid Arteries
  • Flow Conditions in the Intracranial Aneurysm Lumen Are Associated with Inflammation and Degenerative Changes of the Aneurysm Wall
  • Hemodynamics in growing and stable cerebral aneurysms
  • Hemodynamic characteristics of large unruptured internal carotid artery aneurysms prior to rupture: a case control study
  • Hemodynamic-morphological discriminant models for intracranial aneurysm rupture remain stable with increasing sample size
  • Hemodynamic Differences in Intracranial Aneurysms before and after Rupture
  • Guidelines for the Management of Patients With Unruptured Intracranial Aneurysms: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association
  • Rupture Resemblance Score (RRS): toward risk stratification of unruptured intracranial aneurysms using hemodynamic-morphological discriminants
  • Effect of aneurysm and ICA morphology on hemodynamics before and after flow diverter treatment
  • MR Imaging of Myeloperoxidase Activity in a Model of the Inflamed Aneurysm Wall
  • Morphologic and hemodynamic analysis of paraclinoid aneurysms: ruptured versus unruptured
  • CFD: Computational Fluid Dynamics or Confounding Factor Dissemination? The Role of Hemodynamics in Intracranial Aneurysm Rupture Risk Assessment
  • High WSS or Low WSS? Complex Interactions of Hemodynamics with Intracranial Aneurysm Initiation, Growth, and Rupture: Toward a Unifying Hypothesis
  • Mind the Gap: Impact of Computational Fluid Dynamics Solution Strategy on Prediction of Intracranial Aneurysm Hemodynamics and Rupture Status Indicators
  • Computational fluid dynamics simulation of an anterior communicating artery ruptured during angiography
  • Quantifying the Large-Scale Hemodynamics of Intracranial Aneurysms
  • Wall Shear Stress Distribution of Small Aneurysms Prone to Rupture: A Case-Control Study
  • Review of Cerebral Aneurysm Formation, Growth, and Rupture
  • Analysis of Morphologic and Hemodynamic Parameters for Unruptured Posterior Communicating Artery Aneurysms with Oculomotor Nerve Palsy
  • Computational fluid dynamics simulation of an anterior communicating artery ruptured during angiography
  • Low Wall Shear Stress Is Independently Associated With the Rupture Status of Middle Cerebral Artery Aneurysms
  • Effect of Bifurcation Angle Configuration and Ratio of Daughter Diameters on Hemodynamics of Bifurcation Aneurysms
  • Thrombosis Heralding Aneurysmal Rupture: An Exploration of Potential Mechanisms in a Novel Giant Swine Aneurysm Model
  • Analysis of Intra-Aneurysmal Flow for Cerebral Aneurysms with Cerebral Angiography
  • Counterpoint: Realizing the Clinical Utility of Computational Fluid Dynamics--Closing the Gap
  • 1-Hexyl n-cyanoacrylate compound (Neucrylate™ AN), a new treatment for berry aneurysm. III: Initial clinical results
  • Reply:
  • Crossref (352)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Guidelines for the Management of Patients With Unruptured Intracranial Aneurysms
    B. Gregory Thompson, Robert D. Brown, Sepideh Amin-Hanjani, Joseph P. Broderick, Kevin M. Cockroft, E. Sander Connolly, Gary R. Duckwiler, Catherine C. Harris, Virginia J. Howard, S. Claiborne (Clay) Johnston, Philip M. Meyers, Andrew Molyneux, Christopher S. Ogilvy, Andrew J. Ringer, James Torner
    Stroke 2015 46 8
  • High WSS or Low WSS? Complex Interactions of Hemodynamics with Intracranial Aneurysm Initiation, Growth, and Rupture: Toward a Unifying Hypothesis
    H. Meng, V.M. Tutino, J. Xiang, A. Siddiqui
    American Journal of Neuroradiology 2014 35 7
  • Review of Cerebral Aneurysm Formation, Growth, and Rupture
    Nohra Chalouhi, Brian L. Hoh, David Hasan
    Stroke 2013 44 12
  • Unruptured intracranial aneurysms: development, rupture and preventive management
    Nima Etminan, Gabriel J. Rinkel
    Nature Reviews Neurology 2016 12 12
  • Low Wall Shear Stress Is Independently Associated With the Rupture Status of Middle Cerebral Artery Aneurysms
    Yoichi Miura, Fujimaro Ishida, Yasuyuki Umeda, Hiroshi Tanemura, Hidenori Suzuki, Satoshi Matsushima, Shinichi Shimosaka, Waro Taki
    Stroke 2013 44 2
  • CFD: Computational Fluid Dynamics or Confounding Factor Dissemination? The Role of Hemodynamics in Intracranial Aneurysm Rupture Risk Assessment
    J. Xiang, V.M. Tutino, K.V. Snyder, H. Meng
    American Journal of Neuroradiology 2014 35 10
  • Mind the Gap: Impact of Computational Fluid Dynamics Solution Strategy on Prediction of Intracranial Aneurysm Hemodynamics and Rupture Status Indicators
    K. Valen-Sendstad, D.A. Steinman
    American Journal of Neuroradiology 2014 35 3
  • Flow Conditions in the Intracranial Aneurysm Lumen Are Associated with Inflammation and Degenerative Changes of the Aneurysm Wall
    J. Cebral, E. Ollikainen, B.J. Chung, F. Mut, V. Sippola, B.R. Jahromi, R. Tulamo, J. Hernesniemi, M. Niemelä, A. Robertson, J. Frösen
    American Journal of Neuroradiology 2017 38 1
  • Hemodynamic Stress, Inflammation, and Intracranial Aneurysm Development and Rupture: A Systematic Review
    Francesco Signorelli, Sapir Sela, Loreto Gesualdo, Sophie Chevrel, Félix Tollet, Cyril Pailler-Mattei, Leonello Tacconi, Francis Turjman, Angelo Vacca, David B. Schul
    World Neurosurgery 2018 115
  • Vessel Wall Enhancement in Unruptured Intracranial Aneurysms: An Indicator for Higher Risk of Rupture? High-Resolution MR Imaging and Correlated Histologic Findings
    N. Larsen, C. von der Brelie, D. Trick, C.H. Riedel, T. Lindner, J. Madjidyar, O. Jansen, M. Synowitz, C. Flüh
    American Journal of Neuroradiology 2018 39 9

More in this TOC Section

  • Contour Neurovascular System: Five Year Follow Up
  • Effect of SARS-CoV2 on Endovascular Thrombectomy
  • Flow diversion for distal circulation aneurysms
Show more NEUROINTERVENTION

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire