Evaluation of CT Perfusion in the Setting of Cerebral Ischemia: Patterns and Pitfalls

An 87-year-old woman presenting with acute dysarthria, left facial droop, and left-sided weakness. On admission, NCCT and CTP were performed concurrently. A, NCCT shows some microvascular ischemic changes posteriorly. B−D, CTP maps, CBF (B), CBV (C), and MTT (D), demonstrate a large area of matched deficit on CBV and MTT maps, indicative of core infarct in the right MCA territory.

A 64-year-old man presenting with headache and acute aphasia. A, On admission, NCCT and CTP were performed. NCCT shows no evidence of acute infarction. B, CT perfusion CBF map shows a region of decreased perfusion within the posterior segment of the left MCA territory (arrows). D, MTT map shows a corresponding prolongation within this same region (arrows). C, CBV map demonstrates no abnormality, therefore, representing a CBV/MTT mismatch or ischemic penumbra.

A 74-year-old man who presented to the emergency department after a fall with left-sided weakness. Initial CT findings were normal (not shown). A, DWI sequence obtained 2 days later demonstrated an acute/subacute right frontal infarct. B, Several hours later, the patient had new contralateral symptoms, which prompted this CTP study. NCCT at that time demonstrated the right frontal opercular infarct. C−E, CT perfusion demonstrates asymmetric perfusion with relatively increased CBV (C), increased CBF (D), and decreased MTT (E) in this region (arrows) compared with the contralateral brain. This is consistent with postischemic hyperperfusion. Of note, no abnormalities are seen in the left hemisphere. F, The following day, the patient's symptoms progressed, and follow-up NCCT shows hemorrhage in the region of subacute infarction.

A 76-year-old man presenting with acute right-sided symptoms. A, NCCT is normal. CTP map demonstrates a large left MCA stroke with penumbra. B, The CBF map and D, the MTT map demonstrate decreased flow and prolongation of MTT in most of the left MCA territory (arrows) with a CBF (10 mL 100 g1 min1). C, On the CBV map, there is a region of decreased perfusion in the left basal ganglia only (arrows). This represents a CBV/MTT mismatch or ischemic penumbra. The CBV on the ischemic side is 0.6 mL × 100 g⁻¹. Relative MTT on the ischemic side is 500% increased within the core and 200% increased within the penumbra compared with homologous contralateral brain.

A 58-year-old man presenting with acute left hemiparesis and what was thought to be acute right MCA syndrome. A, CTP at admission demonstrates symmetric and normal-appearing perfusion; CBV is shown. B, However, an acute infarct is seen on DWI outside the volume imaged during CTP.

A 61-year-old man presenting with an acute right Wallenberg syndrome. A and B, CBV (A) and MTT (B) maps (here shown in reverse color scheme) obtained through the level of the posterior fossa show an area of ischemic penumbra in the right posterior inferior cerebellar artery territory (arrows). C, DWI confirms a right lateral medullary infarct with salvage of the right inferior cerebellar hemisphere penumbra.

A 55-year-old woman presenting with left hemiparesis and normal findings on head CT. A, CTP source image shows poor contrast opacification within the right ACA (arrow). Commonly, the A2 segment of the ACA can be used for AIF placement. In this case, this was inadequate and resulted in nondiagnostic functional CTP maps. B, CBV is shown as an example.

A, Inappropriate venous region-of-interest selection resulting in the CBV appearance mimicking global hypoperfusion. Perfusion was symmetric and normal following correct region-of-interest placement in the same patient (not shown). B, An example of appropriate placement of the AIF and VOF regions of interest is shown in the ACA and superior sagittal sinus, respectively. C, The corresponding normal findings on CBV are shown.

A 58-year-old woman with left-sided weakness. A−D, NCCT (A) shows left periatrial microvascular ischemic changes (arrows) corresponding to perfusion abnormalities of CBF (B), CBV (C), and MTT (D) maps (arrows). Strategically located infarcts may be symptomatic though small and difficult to detect. No gross asymmetric perfusion is seen in the region of the right internal capsule. E, DWI performed on the same day shows a small acute infarct in the posterior limb of the right internal capsule.

A 44-year-old woman with a history of anxiety disorder presenting with acute right facial weakness and expressive aphasia. She had no known history of prior stroke. CTP demonstrates a focal area of hypoperfusion in the left frontal lobe within an area of chronic-appearing infarct (arrows). Chronic infarcts have measurable though diminished perfusion. Areas of acute infarct adjacent to chronic infarcts may, therefore, be difficult to detect. NCCT (A), CBF (B), CBV (C), at presentation; DWI (D) 1 day later.

A 76-year-old man with change in mental status. NCCT findings (not shown) were normal. A−C, There is decreased CBF (A) and prolonged MTT (C) in the right MCA and ACA territories with preserved CBV (B). D, CTA reveals severe right ICA stenosis at its origin (arrow).

A 54-year-old woman with dizziness and right-sided weakness. A, NCCT shows no gross abnormality. B, Coronal MIP from CT angiography demonstrates severe M1 of the left MCA and prominent collateral vessels (arrow). C−H, CTP before and following the administration of acetazolamide: pre-CBF (C), post-CBF (D), pre-CBV (E), post-CBV (F), pre-MTT (G), and post-MTT (H) images. Technique and scaling of the images are identical before and after acetazolamide administration. There is global bihemispheric increase in CBF and CBV after acetazolamide administration; however, there is increased asymmetric perfusion between the poststenotic (left) and the nonstenotic territories (right) as seen within the oval regions of interest. This is best seen as prolonged MTT following acetazolamide in portions of the left MCA territory relative to the baseline CT perfusion scan.