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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Case ReportNeurointervention

Platelet Aggregation in Intracranial Stents May Mimic In-Stent Restenosis

M. Mazighi, J.P. Saint Maurice, D. Bresson, Z. Szatmary and E. Houdart
American Journal of Neuroradiology March 2010, 31 (3) 496-497; DOI: https://doi.org/10.3174/ajnr.A1778
M. Mazighi
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J.P. Saint Maurice
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D. Bresson
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Z. Szatmary
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E. Houdart
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Abstract

SUMMARY: We report the case of an early ISR that was due to platelet aggregation despite correct observance of a standard antiplatelet regimen. Biologic testing showed clopidogrel inefficiency, and ISR disappeared on angiography after a loading dose of clopidogrel. This result suggested that the arterial lumen reduction was due to platelet aggregation rather than in-stent myointimal hyperplasia. This observation emphasizes the importance of verifying the efficacy of clopidogrel before placing a stent.

Abbreviations

AP
anteroposterior
CTA
CT angiography
ISR
in-stent restenosis
MCA
middle cerebral artery
TCD
transcranial Doppler
TIA
transient ischemic attack
VASP
vasodilator-stimulated phosphoprotein.
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American Journal of Neuroradiology: 31 (3)
American Journal of Neuroradiology
Vol. 31, Issue 3
1 Mar 2010
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Cite this article
M. Mazighi, J.P. Saint Maurice, D. Bresson, Z. Szatmary, E. Houdart
Platelet Aggregation in Intracranial Stents May Mimic In-Stent Restenosis
American Journal of Neuroradiology Mar 2010, 31 (3) 496-497; DOI: 10.3174/ajnr.A1778

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Platelet Aggregation in Intracranial Stents May Mimic In-Stent Restenosis
M. Mazighi, J.P. Saint Maurice, D. Bresson, Z. Szatmary, E. Houdart
American Journal of Neuroradiology Mar 2010, 31 (3) 496-497; DOI: 10.3174/ajnr.A1778
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