Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • Advancing NeuroMRI with High-Relaxivity Contrast Agents
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • Advancing NeuroMRI with High-Relaxivity Contrast Agents
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates


Improved Turnaround Times | Median time to first decision: 12 days

Research ArticleNeurointervention
Open Access

Predictors of Surface Disruption with MR Imaging in Asymptomatic Carotid Artery Stenosis

H.R. Underhill, C. Yuan, V.L. Yarnykh, B. Chu, M. Oikawa, L. Dong, N.L. Polissar, G.A. Garden, S.C. Cramer and T.S. Hatsukami
American Journal of Neuroradiology March 2010, 31 (3) 487-493; DOI: https://doi.org/10.3174/ajnr.A1842
H.R. Underhill
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
C. Yuan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
V.L. Yarnykh
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
B. Chu
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M. Oikawa
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
L. Dong
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
N.L. Polissar
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
G.A. Garden
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S.C. Cramer
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
T.S. Hatsukami
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Sitzer M,
    2. Muller W,
    3. Siebler M,
    4. et al
    . Plaque ulceration and lumen thrombus are the main sources of cerebral microemboli in high-grade internal carotid artery stenosis. Stroke 1995;26:1231–33
    Abstract/FREE Full Text
  2. 2.↵
    1. Park AE,
    2. McCarthy WJ,
    3. Pearce WH,
    4. et al
    . Carotid plaque morphology correlates with presenting symptomatology. J Vasc Surg 1998;27:872–78, discussion 878–79
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Saam T,
    2. Cai J,
    3. Ma L,
    4. et al
    . Comparison of symptomatic and asymptomatic atherosclerotic carotid plaque features with in vivo MR imaging. Radiology 2006;240:464–72
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Yuan C,
    2. Zhang SX,
    3. Polissar NL,
    4. et al
    . Identification of fibrous cap rupture with magnetic resonance imaging is highly associated with recent transient ischemic attack or stroke. Circulation 2002;105:181–85
    Abstract/FREE Full Text
  5. 5.↵
    1. Takaya N,
    2. Yuan C,
    3. Chu B,
    4. et al
    . Association between carotid plaque characteristics and subsequent ischemic cerebrovascular events: a prospective assessment with MRI—initial results. Stroke 2006;37:818–23
    Abstract/FREE Full Text
  6. 6.↵
    1. Yuan C,
    2. Beach KW,
    3. Smith LH Jr.,
    4. et al
    . Measurement of atherosclerotic carotid plaque size in vivo using high resolution magnetic resonance imaging. Circulation 1998;98:2666–71
    Abstract/FREE Full Text
  7. 7.↵
    1. Hatsukami TS,
    2. Ross R,
    3. Polissar NL,
    4. et al
    . Visualization of fibrous cap thickness and rupture in human atherosclerotic carotid plaque in vivo with high-resolution magnetic resonance imaging. Circulation 2000;102:959–64
    Abstract/FREE Full Text
  8. 8.↵
    1. Saam T,
    2. Ferguson MS,
    3. Yarnykh VL,
    4. et al
    . Quantitative evaluation of carotid plaque composition by in vivo MRI. Arterioscler Thromb Vasc Biol 2005;25:234–39
    Abstract/FREE Full Text
  9. 9.↵
    1. Chu B,
    2. Kampschulte A,
    3. Ferguson MS,
    4. et al
    . Hemorrhage in the atherosclerotic carotid plaque: a high-resolution MRI study. Stroke 2004;35:1079–84
    Abstract/FREE Full Text
  10. 10.↵
    1. Mitsumori LM,
    2. Hatsukami TS,
    3. Ferguson MS,
    4. et al
    . In vivo accuracy of multisequence MR imaging for identifying unstable fibrous caps in advanced human carotid plaques. J Magn Reson Imaging 2003;17:410–20
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Murphy RE,
    2. Moody AR,
    3. Morgan PS,
    4. et al
    . Prevalence of complicated carotid atheroma as detected by magnetic resonance direct thrombus imaging in patients with suspected carotid artery stenosis and previous acute cerebral ischemia. Circulation 2003;107:3053–58
    Abstract/FREE Full Text
  12. 12.↵
    1. Saam T,
    2. Yuan C,
    3. Chu B,
    4. et al
    . Predictors of carotid atherosclerotic plaque progression as measured by noninvasive magnetic resonance imaging. Atherosclerosis 2007;194:e34–42
    CrossRefPubMed
  13. 13.↵
    1. Takaya N,
    2. Yuan C,
    3. Chu B,
    4. et al
    . Presence of intraplaque hemorrhage stimulates progression of carotid atherosclerotic plaques: a high-resolution magnetic resonance imaging study. Circulation 2005;111:2768–75
    Abstract/FREE Full Text
  14. 14.↵
    1. Underhill HR,
    2. Yuan C,
    3. Zhao XQ,
    4. et al
    . Effect of rosuvastatin therapy on carotid plaque morphology and composition in moderately hypercholesterolemic patients: a high-resolution magnetic resonance imaging trial. Am Heart J 2008;155:584.e1–8. Epub 2008 Jan 18
    CrossRefPubMed
  15. 15.↵
    1. Corti R,
    2. Fuster V,
    3. Fayad ZA,
    4. et al
    . Lipid lowering by simvastatin induces regression of human atherosclerotic lesions: two years' follow-up by high-resolution noninvasive magnetic resonance imaging. Circulation 2002;106:2884–87
    Abstract/FREE Full Text
  16. 16.↵
    1. Adams GJ,
    2. Greene J,
    3. Vick GW 3rd.,
    4. et al
    . Tracking regression and progression of atherosclerosis in human carotid arteries using high-resolution magnetic resonance imaging. Magn Reson Imaging 2004;22:1249–58
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. Roederer GO,
    2. Langlois YE,
    3. Yager KA,
    4. et al
    . A simple spectral parameter for accurate classification of severe carotid disease. Bruit 1984;8:174–78
  18. 18.↵
    1. Yuan C,
    2. Kerwin WS,
    3. Yarnykh VL,
    4. et al
    . MRI of atherosclerosis in clinical trials. NMR Biomed 2006;19:636–54
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. Kerwin W,
    2. Xu D,
    3. Liu F,
    4. et al
    . Magnetic resonance imaging of carotid atherosclerosis: plaque analysis. Top Magn Reson Imaging 2007;18:371–78
    PubMed
  20. 20.↵
    1. Nissen SE,
    2. Tuzcu EM,
    3. Schoenhagen P,
    4. et al
    . Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: a randomized controlled trial. JAMA 2004;291:1071–80
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Saam T,
    2. Hatsukami TS,
    3. Yarnykh VL,
    4. et al
    . Reader and platform reproducibility for quantitative assessment of carotid atherosclerotic plaque using 1.5T Siemens, Philips, and General Electric scanners. J Magn Reson Imaging 2007;26:344–52
    CrossRefPubMed
  22. 22.↵
    1. Takaya N,
    2. Cai J,
    3. Ferguson MS,
    4. et al
    . Intra- and interreader reproducibility of magnetic resonance imaging for quantifying the lipid-rich necrotic core is improved with gadolinium contrast enhancement. J Magn Reson Imaging 2006;24:203–10
    CrossRefPubMedWeb of Science
  23. 23.↵
    1. Saam T,
    2. Kerwin WS,
    3. Chu B,
    4. et al
    . Sample size calculation for clinical trials using magnetic resonance imaging for the quantitative assessment of carotid atherosclerosis. J Cardiovasc Magn Reson 2005;7:799–808
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Underhill HR,
    2. Yarnykh VL,
    3. Hatsukami TS,
    4. et al
    . Carotid plaque morphology and composition: initial comparison between 1.5- and 3.0-T magnetic field strengths. Radiology 2008;248:550–60
    CrossRefPubMed
  25. 25.↵
    1. Moore WS,
    2. Barnett HJ,
    3. Beebe HG,
    4. et al
    . Guidelines for carotid endarterectomy: a multidisciplinary consensus statement from the Ad Hoc Committee, American Heart Association. Circulation 1995;91:566–79
    Abstract/FREE Full Text
  26. 26.↵
    Endarterectomy for asymptomatic carotid artery stenosis: Executive Committee for the Asymptomatic Carotid Atherosclerosis Study. JAMA 1995;273:1421–28
    CrossRefPubMedWeb of Science
  27. 27.↵
    1. Rothwell PM,
    2. Gutnikov SA,
    3. Warlow CP
    . Reanalysis of the final results of the European Carotid Surgery Trial. Stroke 2003;34:514–23
    Abstract/FREE Full Text
  28. 28.↵
    1. Barnett HJ,
    2. Taylor DW,
    3. Eliasziw M,
    4. et al
    . Benefit of carotid endarterectomy in patients with symptomatic moderate or severe stenosis: North American Symptomatic Carotid Endarterectomy Trial Collaborators. N Engl J Med 1998;339:1415–25
    CrossRefPubMedWeb of Science
  29. 29.↵
    1. Glagov S,
    2. Weisenberg E,
    3. Zarins CK,
    4. et al
    . Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med 1987;316:1371–75
    CrossRefPubMedWeb of Science
  30. 30.↵
    1. Babiarz LS,
    2. Astor B,
    3. Mohamed MA,
    4. et al
    . Comparison of gadolinium-enhanced cardiovascular magnetic resonance angiography with high-resolution black blood cardiovascular magnetic resonance for assessing carotid artery stenosis. J Cardiovasc Magn Reson 2007;9:63–70
    CrossRefPubMed
  31. 31.↵
    1. Falk E
    . Why do plaques rupture? Circulation 1992;86:III30–42
    PubMed
  32. 32.↵
    1. Seeger JM,
    2. Barratt E,
    3. Lawson GA,
    4. et al
    . The relationship between carotid plaque composition, plaque morphology, and neurologic symptoms. J Surg Res 1995;58:330–36
    CrossRefPubMedWeb of Science
  33. 33.↵
    1. Mathiesen EB,
    2. Bonaa KH,
    3. Joakimsen O
    . Echolucent plaques are associated with high risk of ischemic cerebrovascular events in carotid stenosis: the Tromso study. Circulation 2001;103:2171–75
    Abstract/FREE Full Text
  34. 34.↵
    1. Bernick C,
    2. Kuller L,
    3. Dulberg C,
    4. et al
    . Silent MRI infarcts and the risk of future stroke: the cardiovascular health study. Neurology 2001;57:1222–29
    Abstract/FREE Full Text
  35. 35.↵
    1. Longstreth WT Jr.,
    2. Dulberg C,
    3. Manolio TA,
    4. et al
    . Incidence, manifestations, and predictors of brain infarcts defined by serial cranial magnetic resonance imaging in the elderly: the Cardiovascular Health Study. Stroke 2002;33:2376–82
    Abstract/FREE Full Text
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 31 (3)
American Journal of Neuroradiology
Vol. 31, Issue 3
1 Mar 2010
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Predictors of Surface Disruption with MR Imaging in Asymptomatic Carotid Artery Stenosis
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
H.R. Underhill, C. Yuan, V.L. Yarnykh, B. Chu, M. Oikawa, L. Dong, N.L. Polissar, G.A. Garden, S.C. Cramer, T.S. Hatsukami
Predictors of Surface Disruption with MR Imaging in Asymptomatic Carotid Artery Stenosis
American Journal of Neuroradiology Mar 2010, 31 (3) 487-493; DOI: 10.3174/ajnr.A1842

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Predictors of Surface Disruption with MR Imaging in Asymptomatic Carotid Artery Stenosis
H.R. Underhill, C. Yuan, V.L. Yarnykh, B. Chu, M. Oikawa, L. Dong, N.L. Polissar, G.A. Garden, S.C. Cramer, T.S. Hatsukami
American Journal of Neuroradiology Mar 2010, 31 (3) 487-493; DOI: 10.3174/ajnr.A1842
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • Abbreviations
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Characteristics of intracranial plaque in patients with non-cardioembolic stroke and intracranial large vessel occlusion
  • Roadmap Consensus on Carotid Artery Plaque Imaging and Impact on Therapy Strategies and Guidelines: An International, Multispecialty, Expert Review and Position Statement
  • Plaque Composition as a Predictor of Plaque Ulceration in Carotid Artery Atherosclerosis: The Plaque At RISK Study
  • Change in Carotid Plaque Components: A 4-Year Follow-Up Study With Serial MR Imaging
  • Carotid Plaque Lipid Content and Fibrous Cap Status Predict Systemic CV Outcomes: The MRI Substudy in AIM-HIGH
  • Intraplaque Hemorrhage and the Plaque Surface in Carotid Atherosclerosis: The Plaque At RISK Study (PARISK)
  • Nonpharmacological Lipoprotein Apheresis Reduces Arterial Inflammation in Familial Hypercholesterolemia
  • Intravascular Frequency-Domain Optical Coherence Tomography Assessment of Carotid Artery Disease in Symptomatic and Asymptomatic Patients
  • Arterial Stiffness Is Associated With Carotid Intraplaque Hemorrhage in the General Population: The Rotterdam Study
  • Prediction of High-Risk Plaque Development and Plaque Progression With the Carotid Atherosclerosis Score
  • Blood Pressure Parameters and Carotid Intraplaque Hemorrhage as Measured by Magnetic Resonance Imaging: The Rotterdam Study
  • Intravascular Frequency-Domain Optical Coherence Tomography Assessment of Atherosclerosis and Stent-Vessel Interactions in Human Carotid Arteries
  • Comparison of Carotid Atherosclerotic Plaque Characteristics by High-Resolution Black-Blood MR Imaging between Patients with First-Time and Recurrent Acute Ischemic Stroke
  • Sustained Acceleration in Carotid Atherosclerotic Plaque Progression With Intraplaque Hemorrhage: A Long-Term Time Course Study
  • Carotid Atherosclerotic Plaque Progression and Change in Plaque Composition Over Time: A 5-Year Follow-Up Study Using Serial CT Angiography
  • Discriminating Carotid Atherosclerotic Lesion Severity by Luminal Stenosis and Plaque Burden: A Comparison Utilizing High-Resolution Magnetic Resonance Imaging at 3.0 Tesla
  • Association Between Carotid Artery Plaque Ulceration and Plaque Composition Evaluated With Multidetector CT Angiography
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Connectivity for remote neurovascular procedures
  • Cavernous dural AVF treated by transfacial route
  • A Retrospective Study in Tentorial DAVFs
Show more NEUROINTERVENTION

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire