Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • Advancing NeuroMRI with High-Relaxivity Contrast Agents
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • Advancing NeuroMRI with High-Relaxivity Contrast Agents
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates


Improved Turnaround Times | Median time to first decision: 12 days

Research ArticleBrain

Optimized Preload Leakage-Correction Methods to Improve the Diagnostic Accuracy of Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging in Posttreatment Gliomas

L.S. Hu, L.C. Baxter, D.S. Pinnaduwage, T.L. Paine, J.P. Karis, B.G. Feuerstein, K.M. Schmainda, A.C. Dueck, J. Debbins, K.A. Smith, P. Nakaji, J.M. Eschbacher, S.W. Coons and J.E. Heiserman
American Journal of Neuroradiology January 2010, 31 (1) 40-48; DOI: https://doi.org/10.3174/ajnr.A1787
L.S. Hu
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
L.C. Baxter
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
D.S. Pinnaduwage
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
T.L. Paine
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J.P. Karis
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
B.G. Feuerstein
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
K.M. Schmainda
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
A.C. Dueck
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J. Debbins
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
K.A. Smith
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
P. Nakaji
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J.M. Eschbacher
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S.W. Coons
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J.E. Heiserman
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Sugahara T,
    2. Korogi Y,
    3. Tomiguchi S,
    4. et al
    . Post-therapeutic intra-axial brain tumor: the value of perfusion-sensitive contrast-enhanced MR imaging for differentiating tumor recurrence from nonneoplastic contrast-enhancing tissue. AJNR Am J Neuroradiol 2000; 21: 901–09
    Abstract/FREE Full Text
  2. 2.↵
    1. Hu LS,
    2. Baxter LC,
    3. Smith KA,
    4. et al
    . Relative cerebral blood volume values to differentiate high-grade glioma recurrence from posttreatment radiation effect: direct correlation between image-guided tissue histopathology and localized dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging measurements. AJNR Am J Neuroradiol 2009; 30: 552–58
    Abstract/FREE Full Text
  3. 3.↵
    1. Paulson ES,
    2. Schmainda KM
    . Comparison of dynamic susceptibility-weighted contrast-enhanced MR methods: recommendations for measuring relative cerebral blood volume in brain tumors. Radiology 2008; 249: 601–13
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Boxerman JL,
    2. Schmainda KM,
    3. Weisskoff RM
    . Relative cerebral blood volume maps corrected for contrast agent extravasation significantly correlate with glioma tumor grade, whereas uncorrected maps do not. AJNR Am J Neuroradiol 2006; 27: 859–67
    Abstract/FREE Full Text
  5. 5.↵
    1. Kassner A,
    2. Annesley DJ,
    3. Zhu XP,
    4. et al
    . Abnormalities of the contrast re-circulation phase in cerebral tumors demonstrated using dynamic susceptibility contrast-enhanced imaging: a possible marker of vascular tortuosity. J Magn Reson Imaging 2000; 11: 103–13
    CrossRefPubMed
  6. 6.↵
    1. Lev MH,
    2. Ozsunar Y,
    3. Henson JW,
    4. et al
    . Glial tumor grading and outcome prediction using dynamic spin-echo MR susceptibility mapping compared with conventional contrast-enhanced MR: confounding effect of elevated rCBV of oligodendrogliomas [corrected]. AJNR Am J Neuroradiol 2004; 25: 214–21
    Abstract/FREE Full Text
  7. 7.↵
    1. Johnson G,
    2. Wetzel SG,
    3. Cha S,
    4. et al
    . Measuring blood volume and vascular transfer constant from dynamic, T(2)*-weighted contrast-enhanced MRI. Magn Reson Med 2004; 51: 961–68
    CrossRefPubMed
  8. 8.↵
    1. Bruening R,
    2. Kwong KK,
    3. Vevea MR,
    4. et al
    . Echo-planar MR determination of relative cerebral blood volume in human brain tumors: T1 versus T2 weighting. AJNR Am J Neuroradiol 1996; 17: 831–40
    Abstract
  9. 9.↵
    1. Sugahara T,
    2. Korogi Y,
    3. Kochi M,
    4. et al
    . Perfusion-sensitive MR imaging of gliomas: comparison between gradient-echo and spin-echo echo-planar imaging techniques. AJNR Am J Neuroradiol 2001; 22: 1306–15
    Abstract/FREE Full Text
  10. 10.↵
    1. Sorensen AG
    . Perfusion MR imaging: moving forward. Radiology 2008; 249: 416–17
    CrossRefPubMed
  11. 11.↵
    1. Juluru K,
    2. Vogel-Claussen J,
    3. Macura KJ,
    4. et al
    . MR imaging in patients at risk for developing nephrogenic systemic fibrosis: protocols, practices, and imaging techniques to maximize patient safety. Radiographics 2009; 29: 9–22
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Hu LS,
    2. Baxter LC,
    3. Paine TL
    . Leakage corrected rCBV measurements using prebolus dosing: applications in differentiating glioma recurrence from post-treatment effect at 3T field strength. In: Proceedings of the International Society for Magnetic Resonance in Medicine, Toronto, Ontario, Canada. May 3–9, 2008
  13. 13.↵
    1. Donahue KM,
    2. Krouwer HG,
    3. Rand SD,
    4. et al
    . Utility of simultaneously acquired gradient-echo and spin-echo cerebral blood volume and morphology maps in brain tumor patients. Magn Reson Med 2000; 43: 845–53
    CrossRefPubMedWeb of Science
  14. 14.↵
    1. Rosen BR,
    2. Belliveau JW,
    3. Vevea JM,
    4. et al
    . Perfusion imaging with NMR contrast agents. Magn Reson Med 1990; 14: 249–65
    PubMedWeb of Science
  15. 15.↵
    1. Boxerman JL,
    2. Hamberg LM,
    3. Rosen BR,
    4. et al
    . MR contrast due to intravascular magnetic susceptibility perturbations. Magn Reson Med 1995; 34: 555–66
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Perkiö J,
    2. Aronen HJ,
    3. Kangasmäki A,
    4. et al
    . Evaluation of four postprocessing methods for determination of cerebral blood volume and mean transit time by dynamic susceptibility contrast imaging. Magn Reson Med 2002; 47: 973–81
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. Sadeghi N,
    2. Salmon I,
    3. Decaestecker C,
    4. et al
    . Stereotactic comparison among cerebral blood volume, methionine uptake, and histopathology in brain glioma. AJNR Am J Neuroradiol 2007; 28: 455–61
    Abstract/FREE Full Text
  18. 18.↵
    1. Uematsu H,
    2. Maeda M
    . Double-echo perfusion-weighted MR imaging: basic concepts and application in brain tumors for the assessment of tumor blood volume and vascular permeability. Eur Radiol 2006; 16: 180–06
    CrossRefPubMed
  19. 19.↵
    1. Roberts HC,
    2. Roberts TP,
    3. Brasch RC,
    4. et al
    . Quantitative measurement of microvascular permeability in human brain tumors achieved using dynamic contrast-enhanced MR imaging: correlation with histologic grade. AJNR Am J Neuroradiol 2000; 21: 891–99
    Abstract/FREE Full Text
  20. 20.↵
    1. Manka C,
    2. Träber F,
    3. Gieseke J,
    4. et al
    . Three-dimensional dynamic susceptibility-weighted perfusion MR imaging at 3.0 T: feasibility and contrast agent dose. Radiology 2005; 234: 869–77
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Wedeking P,
    2. Eaton S,
    3. Covell DG,
    4. et al
    . Pharmacokinetic analysis of blood distribution of intravenously administered 153Gd-labeled Gd(DTPA)2- and 99mTc(DTPA) in rats. Magn Reson Imaging 1990; 8: 567–75
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Poetker DM,
    2. Jursinic PA,
    3. Runge-Samuelson CL,
    4. et al
    . Distortion of magnetic resonance images used in gamma knife radiosurgery treatment planning: implications for acoustic neuroma outcomes. Otol Neurotol 2005; 26: 1220–28
    CrossRefPubMed
  23. 23.↵
    1. Stadlbauer A,
    2. Ganslandt O,
    3. Buslei R,
    4. et al
    . Gliomas: histopathologic evaluation of changes in directionality and magnitude of water diffusion at diffusion-tensor MR imaging. Radiology 2006; 240: 803–10
    CrossRefPubMed
  24. 24.↵
    1. Brandsma D,
    2. Stalpers L,
    3. Taal W,
    4. et al
    . Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas. Lancet Oncol 2008; 9: 453–61
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Perry A,
    2. Schmidt RE
    . Cancer therapy-associated CNS neuropathology: an update and review of the literature. Acta Neuropathol 2006; 111: 197–212
    CrossRefPubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 31 (1)
American Journal of Neuroradiology
Vol. 31, Issue 1
1 Jan 2010
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Optimized Preload Leakage-Correction Methods to Improve the Diagnostic Accuracy of Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging in Posttreatment Gliomas
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
L.S. Hu, L.C. Baxter, D.S. Pinnaduwage, T.L. Paine, J.P. Karis, B.G. Feuerstein, K.M. Schmainda, A.C. Dueck, J. Debbins, K.A. Smith, P. Nakaji, J.M. Eschbacher, S.W. Coons, J.E. Heiserman
Optimized Preload Leakage-Correction Methods to Improve the Diagnostic Accuracy of Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging in Posttreatment Gliomas
American Journal of Neuroradiology Jan 2010, 31 (1) 40-48; DOI: 10.3174/ajnr.A1787

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Optimized Preload Leakage-Correction Methods to Improve the Diagnostic Accuracy of Dynamic Susceptibility-Weighted Contrast-Enhanced Perfusion MR Imaging in Posttreatment Gliomas
L.S. Hu, L.C. Baxter, D.S. Pinnaduwage, T.L. Paine, J.P. Karis, B.G. Feuerstein, K.M. Schmainda, A.C. Dueck, J. Debbins, K.A. Smith, P. Nakaji, J.M. Eschbacher, S.W. Coons, J.E. Heiserman
American Journal of Neuroradiology Jan 2010, 31 (1) 40-48; DOI: 10.3174/ajnr.A1787
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Identification of a Single-Dose, Low-Flip-Angle-Based CBV Threshold for Fractional Tumor Burden Mapping in Recurrent Glioblastoma
  • Arterial Spin-Labeling and DSC Perfusion Metrics Improve Agreement in Neuroradiologists Clinical Interpretations of Posttreatment High-Grade Glioma Surveillance MR Imaging--An Institutional Experience
  • Presurgical Identification of Primary Central Nervous System Lymphoma with Normalized Time-Intensity Curve: A Pilot Study of a New Method to Analyze DSC-PWI
  • Performance of Standardized Relative CBV for Quantifying Regional Histologic Tumor Burden in Recurrent High-Grade Glioma: Comparison against Normalized Relative CBV Using Image-Localized Stereotactic Biopsies
  • Perfusion MRI-Based Fractional Tumor Burden Differentiates between Tumor and Treatment Effect in Recurrent Glioblastomas and Informs Clinical Decision-Making
  • Moving Toward a Consensus DSC-MRI Protocol: Validation of a Low-Flip Angle Single-Dose Option as a Reference Standard for Brain Tumors
  • Optimization of Acquisition and Analysis Methods for Clinical Dynamic Susceptibility Contrast MRI Using a Population-Based Digital Reference Object
  • Effects of MRI Protocol Parameters, Preload Injection Dose, Fractionation Strategies, and Leakage Correction Algorithms on the Fidelity of Dynamic-Susceptibility Contrast MRI Estimates of Relative Cerebral Blood Volume in Gliomas
  • MRI Evaluation of Non-Necrotic T2-Hyperintense Foci in Pediatric Diffuse Intrinsic Pontine Glioma
  • Contrast Leakage Patterns from Dynamic Susceptibility Contrast Perfusion MRI in the Grading of Primary Pediatric Brain Tumors
  • Comparison of the Effect of Vessel Size Imaging and Cerebral Blood Volume Derived from Perfusion MR Imaging on Glioma Grading
  • The Added Prognostic Value of Preoperative Dynamic Contrast-Enhanced MRI Histogram Analysis in Patients with Glioblastoma: Analysis of Overall and Progression-Free Survival
  • Impact of Software Modeling on the Accuracy of Perfusion MRI in Glioma
  • Repeatability of Standardized and Normalized Relative CBV in Patients with Newly Diagnosed Glioblastoma
  • ASFNR Recommendations for Clinical Performance of MR Dynamic Susceptibility Contrast Perfusion Imaging of the Brain
  • Bayesian Estimation of Cerebral Perfusion Using Reduced-Contrast-Dose Dynamic Susceptibility Contrast Perfusion at 3T
  • Comparison of 18F-FET PET and Perfusion-Weighted MR Imaging: A PET/MR Imaging Hybrid Study in Patients with Brain Tumors
  • Arterial Spin-Labeling Assessment of Normalized Vascular Intratumoral Signal Intensity as a Predictor of Histologic Grade of Astrocytic Neoplasms
  • Diagnostic Accuracy of Dynamic Contrast-Enhanced MR Imaging Using a Phase-Derived Vascular Input Function in the Preoperative Grading of Gliomas
  • The Role of Preload and Leakage Correction in Gadolinium-Based Cerebral Blood Volume Estimation Determined by Comparison with MION as a Criterion Standard
  • Correlations between Perfusion MR Imaging Cerebral Blood Volume, Microvessel Quantification, and Clinical Outcome Using Stereotactic Analysis in Recurrent High-Grade Glioma
  • Multimodality Assessment of Brain Tumors and Tumor Recurrence
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Optimal MRI Sequence for Identifying Occlusion Location in Acute Stroke: Which Value of Time-Resolved Contrast-Enhanced MRA?
  • Evaluating the Effects of White Matter Multiple Sclerosis Lesions on the Volume Estimation of 6 Brain Tissue Segmentation Methods
  • Quiet PROPELLER MRI Techniques Match the Quality of Conventional PROPELLER Brain Imaging Techniques
Show more Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire