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Improved Turnaround Times | Median time to first decision: 12 days

Research ArticleSpine Imaging and Spine Image-Guided Interventions

Quantitative Cervical Spinal Cord 3T Proton MR Spectroscopy in Multiple Sclerosis

A.F. Marliani, V. Clementi, L. Albini Riccioli, R. Agati, M. Carpenzano, F. Salvi and M. Leonardi
American Journal of Neuroradiology January 2010, 31 (1) 180-184; DOI: https://doi.org/10.3174/ajnr.A1738
A.F. Marliani
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V. Clementi
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L. Albini Riccioli
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R. Agati
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M. Carpenzano
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F. Salvi
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M. Leonardi
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References

  1. 1.↵
    1. He J,
    2. Inglese M,
    3. Li BS,
    4. et al
    . Relapsing-remitting multiple sclerosis: metabolic abnormality in nonenhancing lesions and normal-appearing white matter at MR imaging—initial experience. Radiology 2005; 234: 211–17
    PubMedWeb of Science
  2. 2.↵
    1. Cucurella MG,
    2. Rovira A,
    3. Río J,
    4. et al
    . Proton magnetic resonance spectroscopy in primary and secondary progressive multiple sclerosis. NMR Biomed 2000; 13: 57–63
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Sijens PE,
    2. Mostert JP,
    3. Oudkerk M,
    4. et al
    . 1H MR spectroscopy of the brain in multiple sclerosis subtypes with analysis of the metabolite concentrations in gray and white matter: initial findings. Eur Radiol 2006; 16: 489–95
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Adalsteinsson E,
    2. Langer-Gould A,
    3. Homer RJ,
    4. et al
    . Gray matter N-acetyl aspartate deficits in secondary progressive but not relapsing-remitting multiple sclerosis. AJNR Am J Neuroradiol 2003; 24: 1941–45
    Abstract/FREE Full Text
  5. 5.↵
    1. Narayanan PA,
    2. Doyle TJ,
    3. Lai D,
    4. et al
    . Serial proton magnetic resonance spectroscopic imaging, contrast-enhanced magnetic resonance imaging, and quantitative lesion volumetry in multiple sclerosis. Ann Neurol 1998; 43: 56–71
    CrossRefPubMedWeb of Science
  6. 6.↵
    1. Nelson F,
    2. Poonawalla AH,
    3. Hou P,
    4. et al
    . Improved identification of intracortical lesions in multiple sclerosis with phase-sensitive inversion recovery in combination with fast double inversion recovery MR imaging. AJNR Am J Neuroradiol 2007; 28: 1645–49
    Abstract/FREE Full Text
  7. 7.↵
    1. Chard DT,
    2. Griffin CM,
    3. McLean MA,
    4. et al
    . Brain metabolite changes in cortical grey and normal-appearing white matter in clinically early relapsing-remitting multiple sclerosis. Brain 2002; 125: 2342–52
    Abstract/FREE Full Text
  8. 8.↵
    1. Bozzali M,
    2. Cercignani M,
    3. Sormani MP,
    4. et al
    . Quantification of brain gray matter damage in different MS phenotypes by use of diffusion tensor MR imaging. AJNR Am J Neuroradiol 2002; 23: 985–88
    Abstract/FREE Full Text
  9. 9.↵
    1. Dehmeshki J,
    2. Chard DT,
    3. Leary SM,
    4. et al
    . The normal appearing grey matter in primary progressive multiple sclerosis: a magnetisation transfer imaging study. J Neurol 2003; 250: 67–74
    CrossRefPubMedWeb of Science
  10. 10.↵
    1. Kapeller P,
    2. McLean MA,
    3. Griffin CM,
    4. et al
    . Preliminary evidence for neuronal damage in cortical grey matter and normal appearing white matter in short duration relapsing-remitting multiple sclerosis: a quantitative MR spectroscopic imaging study. J Neurol 2001; 248: 131–38
    CrossRefPubMedWeb of Science
  11. 11.↵
    1. Narayanan PA
    . Magnetic resonance spectroscopy in the monitoring of multiple sclerosis. J Neuroimaging 2005; 15: 46S 57S
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Miki Y,
    2. Grossman RI,
    3. Udupa JK,
    4. et al
    . Relapsing-remitting multiple sclerosis: longitudinal analysis of MR images—lack of correlation between changes in T2 lesion volume and clinical findings. Radiology 1999; 213: 395–99
    CrossRefPubMedWeb of Science
  13. 13.↵
    1. Zivadinov R,
    2. Leist TP
    . Clinical-magnetic resonance imaging correlations in multiple sclerosis. J Neuroimaging 2005; 15: 10S–21S
    CrossRefPubMedWeb of Science
  14. 14.↵
    1. Brex PA,
    2. Ciccarelli O,
    3. O'Riordan JI,
    4. et al
    . A longitudinal study of abnormalities on MRI and disability from multiple sclerosis. N Engl J Med 2002; 346: 158–64
    CrossRefPubMedWeb of Science
  15. 15.↵
    1. Barkhof F
    . The clinico-pathological paradox in multiple sclerosis revisited. Curr Opin Neurol 2002; 15: 239–45
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Wolinsky JS,
    2. Narayana PA,
    3. Fenstermacher MJ
    . Proton magnetic resonance spectroscopy in multiple sclerosis. Neurology 1990; 40: 1764–69
    Abstract/FREE Full Text
  17. 17.↵
    1. Inglese M,
    2. Li BS,
    3. Rusinek H,
    4. et al
    . Diffusely elevated cerebral choline and creatine in relapsing-remitting multiple sclerosis. Magn Reson Med 2003; 50: 190–95
    CrossRefPubMedWeb of Science
  18. 18.↵
    1. De Stefano N,
    2. Narayanan S,
    3. Francis GS,
    4. et al
    . Evidence of axonal damage in the early stages of multiple sclerosis and its relevance to disability. Arch Neurol 2001; 58: 65–70
    CrossRefPubMedWeb of Science
  19. 19.↵
    1. De Stefano N,
    2. Matthews PM,
    3. Fu L,
    4. et al
    . Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis: results of a longitudinal magnetic resonance spectroscopy study. Brain 1998; 121: 1469–77
    Abstract/FREE Full Text
  20. 20.↵
    1. Kapeller P,
    2. Brex PA,
    3. Chard D,
    4. et al
    . Quantitative 1H MRS imaging 14 years after presenting with a clinically isolated syndrome suggestive of multiple sclerosis. Mult Scler 2002; 8: 207–10
    Abstract/FREE Full Text
  21. 21.↵
    1. Kendi AT,
    2. Tan FU,
    3. Kendi M,
    4. et al
    . MR spectroscopy of cervical spinal cord in patients with multiple sclerosis. Neuroradiology 2004; 46: 764–69
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Blamire AM,
    2. Cader S,
    3. Lee M,
    4. et al
    . Axonal damage in the spinal cord of multiple sclerosis patients detected by magnetic resonance spectroscopy. Magn Reson Med 2007; 58: 880–85
    CrossRefPubMedWeb of Science
  23. 23.↵
    1. Henning A,
    2. Schär M,
    3. Kollias SS,
    4. et al
    . Quantitative magnetic resonance spectroscopy in the entire human cervical spinal cord and beyond at 3T. Magn Reson Med 2008; 59: 1250–58
    CrossRefPubMed
  24. 24.↵
    1. Cooke F,
    2. Blamire AM,
    3. Korlpara LP,
    4. et al
    . Proton spectroscopy of the motor pathway in patients with spinocerebellar ataxia (SCA). In: Proceedings of the 13th Annual Meeting of the International Society for Magnetic Resonance in Medicine, Miami Beach, FL. May 7–13, 2005: 1227
  25. 25.↵
    1. Dydak U,
    2. Kollias SS,
    3. Schär M,
    4. et al
    . MR spectroscopy in different regions of the spinal cord and in spinal cord tumors. In: Proceedings of the 13th Annual Meeting of the International Society for Magnetic Resonance in Medicine, Miami Beach, FL. May 7–13, 2005: 813
  26. 26.↵
    1. Ciccarelli O,
    2. Wheeler-Kingshott CA,
    3. McLean MA,
    4. et al
    . Spinal cord spectroscopy and diffusion-based tractography to assess acute disability in multiple sclerosis. Brain 2007; 130: 2220–31
    Abstract/FREE Full Text
  27. 27.↵
    1. Marliani AF,
    2. Clementi V,
    3. Albini-Riccioli L,
    4. et al
    . Quantitative proton magnetic resonance spectroscopy of the human cervical spinal cord at 3 Tesla. Magn Reson Med 2007; 57: 160–63
    CrossRefPubMedWeb of Science
  28. 28.↵
    1. McDonald WI,
    2. Compston A,
    3. Edan G,
    4. et al
    . Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the Diagnosis of Multiple Sclerosis. Ann Neurol 2001; 50: 121–27
    CrossRefPubMedWeb of Science
  29. 29.↵
    1. Tran TK,
    2. Vigneron DB,
    3. Sailasuta N,
    4. et al
    . Very selective suppression pulses for clinical MRSI studies of brain and prostate cancer. Magn Reson Med 2000; 43: 23–33
    CrossRefPubMedWeb of Science
  30. 30.↵
    1. Cooke FJ,
    2. Blamire AM,
    3. Manners DN,
    4. et al
    . Quantitative proton magnetic resonance spectroscopy of the cervical spinal cord. Magn Reson Med 2004; 51: 1122–28
    CrossRefPubMed
  31. 31.↵
    1. Provencher SW.
    . Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 1993; 30: 672–79
    CrossRefPubMedWeb of Science
  32. 32.↵
    1. Gomez-Anson B,
    2. MacManus DG,
    3. Parker GJM,
    4. et al
    . In vivo 1H-magnetic resonance spectroscopy of the spinal cord in humans. Neuroradiology 2000; 42: 515–17
    CrossRefPubMedWeb of Science
  33. 33.↵
    1. Dubey P,
    2. Smith M,
    3. Bonekamp D,
    4. et al
    . Proton MR spectroscopic imaging of the human cervical spine at 3 Tesla. In: Proceedings of the 13th Annual Meeting of the International Society for Magnetic Resonance in Medicine, Miami Beach, FL. May 7–13, 2005: 812
  34. 34.↵
    1. Edden RA,
    2. Bonekamp D,
    3. Smith MA,
    4. et al
    . Proton MR spectroscopic imaging of the medulla and cervical spinal cord. J Magn Reson Imaging 2007; 26: 1101–05
    CrossRefPubMed
  35. 35.↵
    1. Bot JC,
    2. Barkhof F.
    . Spinal-cord MRI in multiple sclerosis: conventional and nonconventional MR techniques. Neuroimaging Clin N Am 2009; 19: 81–99
    CrossRefPubMedWeb of Science
  36. 36.↵
    1. Thorpe JW,
    2. Kidd D,
    3. Moseley IF,
    4. et al
    . Serial gadolinium-enhanced MRI of the brain and spinal cord in early relapsing-remitting multiple sclerosis. Neurology 1996; 46: 373–78
    Abstract/FREE Full Text
  37. 37.↵
    1. Kidd D,
    2. Thorpe JW,
    3. Kendall BE,
    4. et al
    . MRI dynamics of brain and spinal cord in progressive multiple sclerosis. J Neurol Neurosurg Psychiatry 1996; 60: 15–19
    Abstract/FREE Full Text
  38. 38.↵
    1. Bot JC,
    2. Barkhof F,
    3. Polman CH,
    4. et al
    . Spinal cord abnormalities in recently diagnosed MS patients: added value of spinal MRI examination. Neurology 2004; 62: 226–33
    Abstract/FREE Full Text
  39. 39.↵
    1. Bjartmar C,
    2. Kidd G,
    3. Mork S,
    4. et al
    . Neurological disability correlates with spinal cord axonal loss and reduced N-acetyl aspartate in chronic multiple sclerosis patients. Ann Neurol 2000; 48: 893–901
    CrossRefPubMedWeb of Science
  40. 40.↵
    1. Ruiz-Pena JL,
    2. Pinero P,
    3. Sellers G,
    4. et al
    . Magnetic resonance spectroscopy of normal appearing white matter in early relapsing-remitting multiple sclerosis: correlations between disability and spectroscopy. BMC Neurol 2004; 4: 8
    CrossRefPubMed
  41. 41.↵
    1. Bot JC,
    2. Blezer EL,
    3. Kamphorst W,
    4. et al
    . The spinal cord in multiple sclerosis: relationship of high-spatial-resolution quantitative MR imaging findings to histopathologic results. Radiology 2004; 233: 531–40
    PubMedWeb of Science
  42. 42.↵
    1. Bergers E,
    2. Bot JC,
    3. De Groot CJ,
    4. et al
    . Axonal damage in the spinal cord of MS patients occurs largely independent of T2 MRI lesions. Neurology 2002; 59: 1766–71
    Abstract/FREE Full Text
  43. 43.↵
    1. Rashid W,
    2. Davies GR,
    3. Chard DT,
    4. et al
    . Increasing cord atrophy in early relapsing-remitting multiple sclerosis: a 3 year study. J Neurol Neurosurg Psychiatry 2006; 77: 51–55
    Abstract/FREE Full Text
  44. 44.↵
    1. Nijeholt G,
    2. van Walderveen MA,
    3. Castelijns JA,
    4. et al
    . Brain and spinal cord abnormalities in multiple sclerosis: correlation between MRI parameters, clinical subtypes and symptoms. Brain 1998; 121: 687–97
    Abstract/FREE Full Text
  45. 45.↵
    1. Stevenson VL,
    2. Leary SM,
    3. Losseff NA,
    4. et al
    . Spinal cord atrophy and disability in MS: a longitudinal study. Neurology 1998; 51: 234–38
    Abstract/FREE Full Text
  46. 46.↵
    1. Riccioli LA,
    2. Marliani AF,
    3. Clementi V,
    4. et al
    . Evolutive study of relapsing-remitting multiple sclerosis with cervical proton magnetic resonance spectroscopy: a case report. Neuroradiol J 2008; 21: 511–17
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A.F. Marliani, V. Clementi, L. Albini Riccioli, R. Agati, M. Carpenzano, F. Salvi, M. Leonardi
Quantitative Cervical Spinal Cord 3T Proton MR Spectroscopy in Multiple Sclerosis
American Journal of Neuroradiology Jan 2010, 31 (1) 180-184; DOI: 10.3174/ajnr.A1738

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Quantitative Cervical Spinal Cord 3T Proton MR Spectroscopy in Multiple Sclerosis
A.F. Marliani, V. Clementi, L. Albini Riccioli, R. Agati, M. Carpenzano, F. Salvi, M. Leonardi
American Journal of Neuroradiology Jan 2010, 31 (1) 180-184; DOI: 10.3174/ajnr.A1738
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