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Recombinant Tissue Plasminogen Activator Increases Blood-Brain Barrier Disruption in Acute Ischemic Stroke: An MR Imaging Permeability Study

A. Kassner, T.P.L. Roberts, B. Moran, F.L. Silver and D.J. Mikulis
American Journal of Neuroradiology November 2009, 30 (10) 1864-1869; DOI: https://doi.org/10.3174/ajnr.A1774
A. Kassner
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T.P.L. Roberts
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B. Moran
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F.L. Silver
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Article Information

vol. 30 no. 10 1864-1869
DOI 
https://doi.org/10.3174/ajnr.A1774
PubMed 
19661169

Published By 
American Journal of Neuroradiology
Print ISSN 
0195-6108
Online ISSN 
1936-959X
History 
  • Received March 3, 2009
  • Accepted after revision May 19, 2009
  • Published online November 13, 2009.

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  • Latest version (August 6, 2009 - 06:58).
  • Latest version (August 20, 2009 - 06:41).
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Copyright © American Society of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org

Author Information

  1. A. Kassnera,c,
  2. T.P.L. Robertsb,
  3. B. Moranc,
  4. F.L. Silverd and
  5. D.J. Mikulisc,d
  1. aFrom the Department of Diagnostic Imaging (A.K.), Hospital for Sick Children, Toronto, Ontario, Canada
  2. bDepartment of Radiology (T.P.L.R.), The Children's Hospital of Philadelphia, Philadelphia, Pa
  3. cDepartment of Medical Imaging (A.K., B.M., D.J.M.), University of Toronto, Toronto, Ontario, Canada
  4. dDepartments of Neurology (F.L.S.) and Medical Imaging (D.J.M.), Toronto Western Hospital, Toronto, Ontario, Canada.
  1. Please address correspondence to Andrea Kassner, PhD, Department of Medical Imaging, University of Toronto, Fitzgerald Bldg, Room 125, 150 College St, Toronto M5S 3E2, Canada; e-mail: andrea.kassner{at}utoronto.ca
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American Journal of Neuroradiology: 30 (10)
American Journal of Neuroradiology
Vol. 30, Issue 10
1 Nov 2009
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Cite this article
A. Kassner, T.P.L. Roberts, B. Moran, F.L. Silver, D.J. Mikulis
Recombinant Tissue Plasminogen Activator Increases Blood-Brain Barrier Disruption in Acute Ischemic Stroke: An MR Imaging Permeability Study
American Journal of Neuroradiology Nov 2009, 30 (10) 1864-1869; DOI: 10.3174/ajnr.A1774

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Recombinant Tissue Plasminogen Activator Increases Blood-Brain Barrier Disruption in Acute Ischemic Stroke: An MR Imaging Permeability Study
A. Kassner, T.P.L. Roberts, B. Moran, F.L. Silver, D.J. Mikulis
American Journal of Neuroradiology Nov 2009, 30 (10) 1864-1869; DOI: 10.3174/ajnr.A1774
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  • rtPA Directly Protects Neurons After Intracerebral Hemorrhage through PI3K/AKT/mTOR Pathway
  • Blood-brain barrier leakage increases with small vessel disease in acute ischemic stroke
  • Impact of Alcohol Consumption on the Outcome of Ischemic Stroke and Thrombolysis: Role of the Hepatic Clearance of Tissue-Type Plasminogen Activator
  • Understanding the Functions of Endogenous and Exogenous Tissue-Type Plasminogen Activator During Stroke
  • Magnetic Resonance Imaging Profile of Blood-Brain Barrier Injury in Patients With Acute Intracerebral Hemorrhage
  • t-PA-specific modulation of a human blood-brain barrier model involves plasmin-mediated activation of the Rho kinase pathway in astrocytes
  • Matrix Metalloproteinase-2-Mediated Occludin Degradation and Caveolin-1-Mediated Claudin-5 Redistribution Contribute to Blood-Brain Barrier Damage in Early Ischemic Stroke Stage
  • Contrast-Enhanced MR Imaging in Acute Ischemic Stroke: T2* Measures of Blood-Brain Barrier Permeability and Their Relationship to T1 Estimates and Hemorrhagic Transformation
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