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[18F] Fluorodeoxyglucose–Positron-Emission Tomography and MR Imaging Coregistration for Presurgical Evaluation of Medically Refractory Epilepsy

K.K. Lee and N. Salamon
American Journal of Neuroradiology November 2009, 30 (10) 1811-1816; DOI: https://doi.org/10.3174/ajnr.A1637
K.K. Lee
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N. Salamon
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    Fig 1.

    MTS in a 31-year-old woman. A, FDG-PET image was read as having normal findings. B, However, the FLAIR image shows some question of increased T2 signal intensity in the right hippocampus. C, FDG-PET/MR imaging coregistration demonstrates subtle hypometabolism of the right mesial temporal structures. Because neurocoginitive testing also demonstrated impaired function of right mesial temporal structures, right anteromedial temporal lobectomy and hippocampectomy were performed. FDG-PET/MR imaging coregistration facilitated localization of the metabolically abnormal area that was subtle when read by FDG-PET alone.

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    Fig 2.

    FCD type II in a 5-year-old girl. A, T2-weighted MR image demonstrates hyperintensity in the left frontal white matter suggestive of FCD. B, With FDG-PET/MR imaging coregistration, a focal area of hypometabolism is seen correlating to the lesion. Pathologic findings of the surgical resection specimen were consistent with FCD type II.

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    Fig 3.

    FCD type I in a 3-year-old boy. A, T2-weighted MR image shows questionable hyperintensity and atrophy in the left temporal pole. B, FDG-PET/MR imaging coregistration shows that this area corresponds to an area of mild hypometabolism. After a left lateral temporal lobe resection, pathologic findings were consistent with FCD type I.

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    Fig 4.

    Tumor with surrounding FCD in a 7-year-old girl. A, T2-weighted MR image shows a lesion in the right mesiotemporal lobe with perilesional blurring of the gray and white matter in the right anterior temporal pole. B, FDG-PET/MR imaging coregistration demonstrates relative hypometabolism in right temporal lobe localized at the lesion and the surrounding abnormal gray and white matter. After a right anterior temporal lobectomy, pathologic findings of the surgical specimen showed a neoplasm with features of oligoastrocytoma with surrounding FCD type I.

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    Fig 5.

    Tumor with surrounding FCD in an 18-year-old woman. A, FLAIR sequence shows hyperintensity of the left amygdala and temporal lobe. B, FDG-PET/MR imaging coregistration demonstrates an area of hypometabolism extending beyond the lesion seen with MR imaging. After surgical resection, ganglioglioma was seen on pathology of the lesion (white arrow). Pathology of the area of hypometabolism surrounding the lesion (yellow arrow) showed histology consistent with FCD type I.

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    Fig 6.

    TSC in a 5-year-old girl. A, T2 axial image shows numerous hyperintense tubers on both temporal lobes. B, FDG-PET/MR imaging coregistration demonstrates an area of hypometabolism in the right temporal pole that is significantly larger than the tuber size. EEG demonstrated the presence of right temporal interictal discharges suggesting an epileptogenic zone in this area. Right temporal lobectomy was performed with good postsurgical seizure control.

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American Journal of Neuroradiology: 30 (10)
American Journal of Neuroradiology
Vol. 30, Issue 10
1 Nov 2009
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Cite this article
K.K. Lee, N. Salamon
[18F] Fluorodeoxyglucose–Positron-Emission Tomography and MR Imaging Coregistration for Presurgical Evaluation of Medically Refractory Epilepsy
American Journal of Neuroradiology Nov 2009, 30 (10) 1811-1816; DOI: 10.3174/ajnr.A1637

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[18F] Fluorodeoxyglucose–Positron-Emission Tomography and MR Imaging Coregistration for Presurgical Evaluation of Medically Refractory Epilepsy
K.K. Lee, N. Salamon
American Journal of Neuroradiology Nov 2009, 30 (10) 1811-1816; DOI: 10.3174/ajnr.A1637
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  • Article
    • Abstract
    • Presurgical Evaluation and FDG-PET/MR Imaging Coregistration for Medically Refractory Epilepsy at UCLA
    • MTS
    • FCD
    • Epileptogenic Tumors
    • TSC
    • Discussion and Future Directions
    • Conclusions
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
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  • Clinical Value of Hybrid TOF-PET/MR Imaging-Based Multiparametric Imaging in Localizing Seizure Focus in Patients with MRI-Negative Temporal Lobe Epilepsy
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    Radiology 2013 267 1
  • Imaging in the surgical treatment of epilepsy
    John S. Duncan
    Nature Reviews Neurology 2010 6 10
  • Current status and future role of brain PET/MRI in clinical and research settings
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    European Journal of Nuclear Medicine and Molecular Imaging 2015 42 3
  • Clinical PET/MRI: 2018 Update
    Stephen M. Broski, Ajit H. Goenka, Bradley J. Kemp, Geoffrey B. Johnson
    American Journal of Roentgenology 2018 211 2
  • Validation of FDG-PET/MRI coregistration in nonlesional refractory childhood epilepsy
    Sebastià Rubí, Xavier Setoain, Antonio Donaire, Núria Bargalló, Francesc Sanmartí, Mar Carreño, Jordi Rumià, Anna Calvo, Javier Aparicio, Jaume Campistol, Francesca Pons
    Epilepsia 2011 52 12
  • PET/MRI and PET/MRI/SISCOM coregistration in the presurgical evaluation of refractory focal epilepsy
    S. Fernández, A. Donaire, E. Serès, X. Setoain, N. Bargalló, C. Falcón, F. Sanmartí, I. Maestro, J. Rumià, L. Pintor, T. Boget, J. Aparicio, M. Carreño
    Epilepsy Research 2015 111
  • Neurologic Applications of PET/MR Imaging
    Michelle M. Miller-Thomas, Tammie L.S. Benzinger
    Magnetic Resonance Imaging Clinics of North America 2017 25 2
  • FDG‐PET and magnetoencephalography in presurgical workup of children with localization‐related nonlesional epilepsy
    Elysa Widjaja, Amer Shammas, Reza Vali, Hiroshi Otsubo, Ayako Ochi, O. Carter Snead, Cristina Go, Martin Charron
    Epilepsia 2013 54 4
  • Clinical Value of Hybrid TOF-PET/MR Imaging–Based Multiparametric Imaging in Localizing Seizure Focus in Patients with MRI-Negative Temporal Lobe Epilepsy
    K. Shang, J. Wang, X. Fan, B. Cui, J. Ma, H. Yang, Y. Zhou, G. Zhao, J. Lu
    American Journal of Neuroradiology 2018 39 10
  • From PET/CT to PET/MRI: Advances in Instrumentation and Clinical Applications
    Zhenhua Hu, Weidong Yang, Haixiao Liu, Kun Wang, Chengpeng Bao, Tianming Song, Jing Wang, Jie Tian
    Molecular Pharmaceutics 2014 11 11

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