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Research ArticlePediatric Neuroimaging

Quantitative Differentiation Between Healthy and Disordered Brain Matter in Patients with Neurofibromatosis Type I Using Diffusion Tensor Imaging

S.J.P.M. van Engelen, L.C. Krab, H.A. Moll, A. de Goede-Bolder, S.M.F. Pluijm, C.E. Catsman-Berrevoets, Y. Elgersma and M.H. Lequin
American Journal of Neuroradiology April 2008, 29 (4) 816-822; DOI: https://doi.org/10.3174/ajnr.A0921
S.J.P.M. van Engelen
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L.C. Krab
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H.A. Moll
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A. de Goede-Bolder
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S.M.F. Pluijm
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C.E. Catsman-Berrevoets
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Y. Elgersma
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M.H. Lequin
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References

  1. ↵
    Huson SM, Compston DA, Harper PS, et al. A genetic study of von Recklinghausen neurofibromatosis in south east Wales. I. Prevalence, fitness, mutation rate, and effect of parental transmission on severity. J Med Genet 1989;26:704–11
    Abstract/FREE Full Text
  2. Aoki S, Barkovich AJ, Nishimura K, et al. Neurofibromatosis types 1 and 2: cranial MR findings. Radiology 1989;172:527–34
    PubMedWeb of Science
  3. North K. Neurofibromatosis type 1. Am J Med Genet 2000;97:119–27
    CrossRefPubMedWeb of Science
  4. ↵
    Menor F, Marti-Bonmati L, Mulas F, et al. Imaging considerations of central nervous system manifestations in pediatric patients with neurofibromatosis type 1. Pediatr Radiol 1991;21:389–94
    CrossRefPubMedWeb of Science
  5. ↵
    DiPaolo DP, Zimmerman RA, Rorke LB, et al. Neurofibromatosis type I: pathologic substrate of high-signal-intensity foci in the brain. Radiology 1995;195:721–24
    PubMedWeb of Science
  6. ↵
    Mori H, Abe O, Okubo T, et al. Diffusion property in a hamartomatous lesion of neurofibromatosis type 1. J Comput Assist Tomogr 2001;25:537–39
    CrossRefPubMed
  7. Eastwood JD, Fiorella DJ, MacFall JF, et al. Increased brain apparent diffusion coefficient in children with neurofibromatosis type 1. Radiology 2001;219:354–58
    PubMedWeb of Science
  8. ↵
    Alkan A, Sigirci A, Kutlu R, et al. Neurofibromatosis type 1: diffusion weighted imaging findings of brain. Eur J Radiol 2005;56:229–34. Epub 2005 Jun 15
    CrossRefPubMed
  9. ↵
    Tognini G, Ferrozzi F, Garlaschi G, et al. Brain apparent diffusion coefficient evaluation in pediatric patients with neurofibromatosis type 1. J Comput Assist Tomogr 2005;29:298–304
    CrossRefPubMed
  10. ↵
    Beaulieu C. The basis of anisotropic water diffusion in the nervous system: a technical review. NMR Biomed 2002;15:435–55
    CrossRefPubMedWeb of Science
  11. ↵
    Le Bihan D, Van Zijl P. From diffusion coefficient to the diffusion tensor. NMR Biomed 2002;15:431–34
    CrossRefPubMedWeb of Science
  12. ↵
    Song S, Sun S, Ramsbottom MJ, et al. Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water. Neuroimage 2002;17:1429–36
    CrossRefPubMedWeb of Science
  13. ↵
    Song S, Yoshino J, Le TQ, et al. Demyelination increases radial diffusivity in corpus callosum of mouse brain. Neuroimage 2005;26:132–40
    CrossRefPubMedWeb of Science
  14. ↵
    Zamboni SL, Loenneker T, Boltshauser E, et al. Contribution of diffusion tensor MR imaging in detecting cerebral microstructural changes in adults with neurofibromatosis type 1. AJNR Am J Neuroradiol 2007;28:773–76
    Abstract/FREE Full Text
  15. ↵
    Gill DS, Hyman SL, Steinberg A, et al. Age-related findings on MRI in neurofibromatosis type 1. Pediatr Radiol 2006;36:1048–56. Epub 2006 Aug 16.
    CrossRefPubMed
  16. ↵
    Neurofibromatosis. Natl Inst Health Consens Dev Conf Consens Statement. 1987;6:1–7
    PubMed
  17. ↵
    Basser PJ, Mattiello J, Le Bihan D. Estimation of the effective self-diffusion tensor from the NMR spin echo. J Magn Reson B 1994;103:247–54
    CrossRefPubMedWeb of Science
  18. ↵
    Conturo TE, McKinstry RC, Akbudak E, et al. Encoding of anisotropic diffusion with tetrahedral gradients: a general mathematical diffusion formalism and experimental results. J Magn Reson Med 1996;35:399–412
  19. ↵
    Neil JJ, Shiran SI, McKinstry RC, et al. Normal brain in human newborns: apparent diffusion coefficient and diffusion anisotropy measured by using diffusion tensor MR imaging. Radiology 1998;209:57–66
    PubMedWeb of Science
  20. ↵
    Szafer A, Zhong J, Anderson AW, et al. Diffusion-weighted imaging in tissues: theoretical models. NMR Biomed 1995;8:289–96
    PubMedWeb of Science
  21. ↵
    Basser PJ, Jones DK. Diffusion-tensor MRI : theory, experimental design and data analysis—a technical review. NMR Biomed 2002;15:457–67
  22. ↵
    Wang PY, Kaufmann WE, Koth CW, et al. Thalamic involvement in neurofibromatosis type 1: evaluation with proton magnetic resonance spectroscopic imaging. Ann Neurol 2000;47:477–84
    CrossRefPubMedWeb of Science
  23. ↵
    Van Pul C, Buijs J, Janssen MJ, et al. Selecting the best index for following the temporal evolution of apparent diffusion coefficient and diffusion anisotropy after hypoxic-ischemic white matter injury in neonates. AJNR Am J Neuroradiol 2005;26:469–81
    Abstract/FREE Full Text
  24. ↵
    Shimony JS, McKinstry RC, Akbudak E, et al. Quantitative diffusion-tensor anisotropy brain MR imaging: normative human data and anatomic analysis. Radiology 1999;212:770–84
    PubMedWeb of Science
  25. ↵
    Bonekamp D, Nagae LM, Degaonkar M, et al. Diffusion tensor imaging in children and adolescents: reproducibility, hemispheric, and age-related differences. Neuroimage 2007;34:733–42
    CrossRefPubMedWeb of Science
  26. ↵
    Ono J, Harada K, Mano T, et al. Differentiation of dys- and demyelination using diffusional anisotropy. Pediatr Radiol 1997;16:63–66
  27. Takahashi M, Ono J, Harada K, et al. Diffusional anisotropy in cranial nerves with maturation: quantitative evaluation with diffusion MR imaging in rats. Radiology 2000;216:881–85
    CrossRefPubMedWeb of Science
  28. ↵
    Nair G, Tanahashi Y, Low HP, et al. Myelination and long diffusion times alter diffusion-tensor-imaging contrast in myelin-deficient shiverer mice. Neuroimage 2005;28:165–74. Epub 2005 Jul 14
    CrossRefPubMedWeb of Science
  29. ↵
    Mukherjee P, Miller JH, Shimony JS, et al. Diffusion-tensor MR imaging of gray and white matter development during normal human brain maturation. AJNR Am J Neuroradiol 2002;23:1445–56
    Abstract/FREE Full Text
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American Journal of Neuroradiology: 29 (4)
American Journal of Neuroradiology
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April 2008
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S.J.P.M. van Engelen, L.C. Krab, H.A. Moll, A. de Goede-Bolder, S.M.F. Pluijm, C.E. Catsman-Berrevoets, Y. Elgersma, M.H. Lequin
Quantitative Differentiation Between Healthy and Disordered Brain Matter in Patients with Neurofibromatosis Type I Using Diffusion Tensor Imaging
American Journal of Neuroradiology Apr 2008, 29 (4) 816-822; DOI: 10.3174/ajnr.A0921

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Quantitative Differentiation Between Healthy and Disordered Brain Matter in Patients with Neurofibromatosis Type I Using Diffusion Tensor Imaging
S.J.P.M. van Engelen, L.C. Krab, H.A. Moll, A. de Goede-Bolder, S.M.F. Pluijm, C.E. Catsman-Berrevoets, Y. Elgersma, M.H. Lequin
American Journal of Neuroradiology Apr 2008, 29 (4) 816-822; DOI: 10.3174/ajnr.A0921
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Cited By...

  • Understanding autism spectrum disorder and social functioning in children with neurofibromatosis type 1: protocol for a cross-sectional multimodal study
  • Diffusion Tensor Imaging and Fiber Tractography in Children with Craniosynostosis Syndromes
  • Neurofibromatosis Type 1: Modeling CNS Dysfunction
  • Corpus Callosum Morphology and Microstructure Assessed Using Structural MR Imaging and Diffusion Tensor Imaging: Initial Findings in Adults with Neurofibromatosis Type 1
  • Brain structure and function in neurofibromatosis type 1: current concepts and future directions
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  • Clinical SVR of Fetal Brain MRI
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