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Improved Turnaround Times | Median time to first decision: 12 days

Research ArticleBRAIN

Automated Discrimination Between Very Early Alzheimer Disease and Controls Using an Easy Z-Score Imaging System for Multicenter Brain Perfusion Single-Photon Emission Tomography

H. Matsuda, S. Mizumura, T. Nagao, T. Ota, T. Iizuka, K. Nemoto, N. Takemura, H. Arai and A. Homma
American Journal of Neuroradiology April 2007, 28 (4) 731-736;
H. Matsuda
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S. Mizumura
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T. Nagao
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T. Ota
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T. Iizuka
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K. Nemoto
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N. Takemura
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H. Arai
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A. Homma
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References

  1. ↵
    Minoshima S, Foster NL, Kuhl DE. Posterior cingulate cortex in Alzheimer's disease. Lancet 1994;344:895
    PubMedWeb of Science
  2. ↵
    Minoshima S, Giordani B, Berent S, et al. Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease. Ann Neurol 1997;42:85–94
    CrossRefPubMedWeb of Science
  3. ↵
    Johnson KA, Jones K, Holman BL, et al. Preclinical prediction of Alzheimer's disease using SPECT. Neurology 1998;50:1563–71
    Abstract/FREE Full Text
  4. ↵
    Kogure D, Matsuda H, Ohnishi T, et al. Longitudinal evaluation of early Alzheimer's disease using brain perfusion SPECT. J Nucl Med 2000;41:1155–62
    Abstract/FREE Full Text
  5. ↵
    Imabayashi E, Matsuda H, Asada T, et al. Superiority of 3-dimensional stereotactic surface projection analysis over visual inspection in discrimination of patients with very early Alzheimer's disease from controls using brain perfusion SPECT. J Nucl Med 2004;45:1450–57
    Abstract/FREE Full Text
  6. ↵
    Petersen RC, Doody R, Kurz A, et al. Current concepts in mild cognitive impairment. Arch Neurol 2001;58:1985–92
    CrossRefPubMedWeb of Science
  7. ↵
    Matsuda H, Mizumura S, Soma T, et al. Conversion of brain SPECT images between different collimators and reconstruction processes for analysis using statistical parametric mapping. Nucl Med Commun 2004;25:67–74
    CrossRefPubMed
  8. ↵
    Friston KJ. Analyzing brain images: principles and overview. In: Frackowiak RSJ, Friston KJ, Frith CD, et al, eds. Human Brain Function. San Diego, Calif: Academic Press;1997 :25–41
  9. ↵
    Kanetaka H, Matsuda H, Asada T, et al. Effects of partial volume correction on discrimination between very early Alzheimer's dementia and controls using brain perfusion SPECT. Eur J Nucl Med Mol Imaging 2004;31:975–80
    PubMed
  10. ↵
    Hamuro A, Isono H, Takenaka H, et al. SPECT study in oldest old Alzheimer disease patients. Am J Geriatr Psychiatry 2004;12:658
    PubMed
  11. ↵
    McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Service Task Force on Alzheimer's disease. Neurology 1984;34:939–44
    Abstract/FREE Full Text
  12. ↵
    Hughes CP, Berg L, Danziger WL, et al. A new clinical scale for the staging of dementia. Br J Psychiatry 1982;140:566–72
    Abstract/FREE Full Text
  13. ↵
    Folstein MF, Folstein SE, McHugh PR. Mini-Mental State: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189–98
    CrossRefPubMedWeb of Science
  14. ↵
    Ohnishi T, Matsuda H, Hashimoto T, et al. Abnormal regional cerebral blood flow in childhood autism. Brain 2000;123:1838–44
    Abstract/FREE Full Text
  15. ↵
    Metz CE, Herman BA, Roe CA. Statistical comparison of two ROC-curve estimates obtained from partially-paired datasets. Med Decis Making 1998;18:110–21
    Abstract/FREE Full Text
  16. ↵
    Herholz K, Salmon E, Perani D, et al. Discrimination between Alzheimer dementia and controls by automated analysis of multicenter FDG PET. Neuroimage 2002;17:302–16
    CrossRefPubMedWeb of Science
  17. ↵
    Silverman DH. Brain 18F-FDG PET in the diagnosis of neurodegenerative dementias: comparison with perfusion SPECT and with clinical evaluations lacking nuclear imaging. J Nucl Med 2004;45:594–607
    Abstract/FREE Full Text
  18. ↵
    Mosconi L. Brain glucose metabolism in the early and specific diagnosis of Alzheimer's disease: FDG-PET studies in MCI and AD. Eur J Nucl Med Mol Imaging 2005;32:486–510
    CrossRefPubMedWeb of Science
  19. ↵
    Herholz K, Schopphoff H, Schmidt M, et al. Direct comparison of spatially normalized PET and SPECT scans in Alzheimer's disease. J Nucl Med 2002;43:21–26
    Abstract/FREE Full Text
  20. ↵
    Mizumura S, Kumita S, Cho K, et al. Development of quantitative analysis method for stereotactic brain image: assessment of reduced accumulation in extent and severity using anatomical segmentation. Ann Nucl Med 2003;17:289–95
    PubMed
  21. ↵
    Lobaugh NJ, Caldwell CB, Black SE, et al. Three brain SPECT region-of-interest templates in elderly people: normative values, hemispheric asymmetries, and a comparison of single- and multihead cameras. J Nucl Med 2000;41:45–56
    Abstract/FREE Full Text
  22. Ribeiro MJ, Remy P, Bendriem B, et al. Comparison of clinical data sets acquired on different tomographs using 6–18F-L-DOPA. Eur J Nucl Med 2000;27:707–12
    CrossRefPubMed
  23. ↵
    Van Laere K, Koole M, Versijpt J, et al. Transfer of normal 99mTc-ECD brain SPET databases between different gamma cameras. Eur J Nucl Med 2001;28:435–49
    CrossRefPubMed
  24. ↵
    Minoshima S, Frey KA, Koeppe RA, et al. A diagnostic approach in Alzheimer's disease using three-dimensional stereotactic surface projections of fluorine-18-FDG PET. J Nucl Med 1995;36:1238–48
    Abstract/FREE Full Text
  25. ↵
    Ishii K, Willoch F, Minoshima S, et al. Statistical brain mapping of 18F-FDG PET in Alzheimer's disease: validation of anatomic standardization for atrophied brains. J Nucl Med 2001;42:548–57
    Abstract/FREE Full Text
  26. ↵
    Bonte FJ, Harris TS, Roney CA, et al. Differential diagnosis between Alzheimer's and frontotemporal disease by the posterior cingulate sign. J Nucl Med 2004;45:771–74
    Abstract/FREE Full Text
  27. ↵
    Kaneko K, Kuwabara Y, Sasaki M, et al. Posterior cingulate hypoperfusion in Alzheimer's disease, senile dementia of Alzheimer type, and other dementias evaluated by three-dimensional stereotactic surface projections using Tc-99m HMPAO SPECT. Clin Nucl Med 2004;29:362–66
    PubMed
  28. ↵
    Kemp PM, Hoffman SA, Holmes C, et al. The contribution of statistical parametric mapping in the assessment of precuneal and medial temporal lobe perfusion by 99mTc-HMPAO SPECT in mild Alzheimer's and Lewy body dementia. Nucl Med Commun 2005;26:1099–106
    PubMed
  29. ↵
    Hanyu H, Shimuzu T, Tanaka Y, et al. Effect of age on regional cerebral blood flow patterns in Alzheimer's disease patients. J Neurol Sci 2003;209:25–30
    CrossRefPubMed
  30. ↵
    Kim EJ, Cho SS, Jeong Y, et al. Glucose metabolism in early onset versus late onset Alzheimer's disease: an SPM analysis of 120 patients. Brain 2005;128:1790–801
    Abstract/FREE Full Text
  31. ↵
    Hirao K, Ohnishi T, Hirata Y, et al. The prediction of rapid conversion to Alzheimer's disease in mild cognitive impairment using regional cerebral blood flow SPECT. Neuroimage 2005;28:1014–21
    CrossRefPubMedWeb of Science
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American Journal of Neuroradiology: 28 (4)
American Journal of Neuroradiology
Vol. 28, Issue 4
April 2007
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H. Matsuda, S. Mizumura, T. Nagao, T. Ota, T. Iizuka, K. Nemoto, N. Takemura, H. Arai, A. Homma
Automated Discrimination Between Very Early Alzheimer Disease and Controls Using an Easy Z-Score Imaging System for Multicenter Brain Perfusion Single-Photon Emission Tomography
American Journal of Neuroradiology Apr 2007, 28 (4) 731-736;

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Automated Discrimination Between Very Early Alzheimer Disease and Controls Using an Easy Z-Score Imaging System for Multicenter Brain Perfusion Single-Photon Emission Tomography
H. Matsuda, S. Mizumura, T. Nagao, T. Ota, T. Iizuka, K. Nemoto, N. Takemura, H. Arai, A. Homma
American Journal of Neuroradiology Apr 2007, 28 (4) 731-736;
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