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Research ArticleBRAIN

Effect of Training and Experience on Qualitative and Quantitative CT Perfusion Data

P.C. Sanelli, G. Nicola, R. Johnson, A.J. Tsiouris, I. Ougorets, C. Knight, B. Frommer, S. Veronelli and R.D. Zimmerman
American Journal of Neuroradiology March 2007, 28 (3) 428-432;
P.C. Sanelli
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G. Nicola
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R. Johnson
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A.J. Tsiouris
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I. Ougorets
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C. Knight
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B. Frommer
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S. Veronelli
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R.D. Zimmerman
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  • Fig 1.
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    Fig 1.

    Cerebral blood flow map demonstrates placement of the standard region-of-interest (ROI) sampling global cortical perfusion with ROI in the bilateral anterior, middle, and posterior cerebral artery territories.

Tables

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    Table 1:

    Experience level of observers

    Skill levelExperience at Position (Years)Experience Processing CTP (Years)
    Junior CT technologist30
    Senior CT technologist230
    Radiology resident physician30
    Neuroradiology fellow1*0.5
    Neurology attending physician40
    Neuroradiology attending physician23†
    • * Additional 4 years of residency training in radiology.

    • † 1 year of experience processing CT perfusion data during fellowship training.

    • View popup
    Table 2:

    Qualitative assessment of ischemia/infarct (κ statistics)

    Observer 1Observer 2Observer 3Observer 4Observer 5
    Observer 20.76
    Observer 30.670.69
    Observer 40.860.640.55
    Observer 50.870.640.570.74
    Observer 61.00.870.660.860.86
    • Note:—Observer 1, radiology resident physician; observer 2, neuroradiology attending physician; observer 3, neurology attending physician; observer 4, neuroradiology fellow; observer 5, junior CT technologist; observer 6, senior CT technologist.

    • View popup
    Table 3:

    Quantitative assessment of ischemia/infarct (mean quantitative values)

    Observer 1Observer 2Observer 4Observer 5Observer 6
    CBF (mL/100 g/min)13.3814.5525.9620.8718.85
    CBV (mL/100 g)1.401.441.901.781.59
    MTT (seconds)10.6510.8310.119.6510.08
    • Note:—CBF indicates cerebral blood flow; CBV, cerebral blood volume; MTT, mean transit time. Observer 1, radiology resident physician; observer 2, neuroradiology attending physician; observer 4, neuroradiology fellow; observer 5, junior CT technologist; observer 6, senior CT technologist. Observer 3, the neurology attending physician did not participate in this section of the study.

    • View popup
    Table 4:

    Coefficient of variation (%) among all observers (interobserver variability)

    Ischemia/InfarctGlobal Cortical Perfusion
    CBF (mL/100 g/min)27.1011.88
    CBV (mL/100 g)13.3313.66
    MTT (seconds)4.663.55
    • Note:—CBF indicates cerebral blood flow; CBV, cerebral blood volume; MTT, mean transit time.

    • View popup
    Table 5:

    Quantitative assessment of global cortical perfusion (mean quantitative values)

    Observer 1Observer 2Observer 3Observer 4Observer 5Observer 6
    CBF (mL/100 g/min)42.6036.5241.4446.8551.5341.58
    CBV (mL/100 g)2.041.982.132.242.782.01
    MTT (seconds)5.395.875.355.395.595.50
    • Note:—CBF indicates cerebral blood flow; CBV, cerebral blood volume; MTT, mean transit time. Observer 1, radiology resident physician; observer 2, neuroradiology attending physician; observer 3, neurology attending physician; observer 4, neuroradiology fellow; observer 5, junior CT technologist; observer 6, senior CT technologist.

    • View popup
    Table 6:

    Coefficient of variation (%) for each observer (intraobserver variability)

    Observer 1Observer 2Observer 3Observer 4Observer 5Observer 6
    CBF (mL/100 g/min)2.560.356.600.602.172.34
    CBV (mL/100 g)1.310.331.868.383.872.19
    MTT (seconds)1.142.29—*5.773.781.52
    • Note:—CBF indicates cerebral blood flow; CBV, cerebral blood volume; MTT, mean transit time. Observer 1, radiology resident physician; observer 2, neuroradiology attending physician; observer 3, neurology attending physician; observer 4, neuroradiology fellow; observer 5, junior CT technologist; observer 6, senior CT technologist.

    • * Observer 3 had missing data for the MTT quantitative measurements on the repeated 10 CT perfusion datasets.

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American Journal of Neuroradiology: 28 (3)
American Journal of Neuroradiology
Vol. 28, Issue 3
March 2007
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Cite this article
P.C. Sanelli, G. Nicola, R. Johnson, A.J. Tsiouris, I. Ougorets, C. Knight, B. Frommer, S. Veronelli, R.D. Zimmerman
Effect of Training and Experience on Qualitative and Quantitative CT Perfusion Data
American Journal of Neuroradiology Mar 2007, 28 (3) 428-432;

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Effect of Training and Experience on Qualitative and Quantitative CT Perfusion Data
P.C. Sanelli, G. Nicola, R. Johnson, A.J. Tsiouris, I. Ougorets, C. Knight, B. Frommer, S. Veronelli, R.D. Zimmerman
American Journal of Neuroradiology Mar 2007, 28 (3) 428-432;
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