Research ArticleBRAIN
Whole-Brain and Regional Brain Atrophy in Amyotrophic Lateral Sclerosis
D.M. Mezzapesa, A. Ceccarelli, F. Dicuonzo, A. Carella, M.F. De Caro, M. Lopez, V. Samarelli, P. Livrea and I.L. Simone
American Journal of Neuroradiology February 2007, 28 (2) 255-259;
D.M. Mezzapesa
A. Ceccarelli
F. Dicuonzo
A. Carella
M.F. De Caro
M. Lopez
V. Samarelli
P. Livrea

References
- ↵Rowland LP, Shneider NA. Amyotrophic lateral sclerosis. N Engl J Med 2001;344:1688–700
- ↵Lomen-Hoerth C, Murphy J, Langmore S, et al. Are amyotrophic lateral sclerosis patients cognitively normal? Neurology 2003;60:1094–97
- ↵Massman PJ, Sims J, Cooke N, et al. Prevalence and correlates of neuropsychological deficits in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 1996;61:450–55
- ↵Ringholz GM, Appel SH, Bradshaw M, et al. Prevalence and patterns of cognitive impairment in sporadic ALS. Neurology 2005;65:586–90
- ↵Strong MJ, Lomen-Hoerth C, Caselli RJ, et al. Cognitive impairment, frontotemporal dementia, and the motor neuron diseases. Ann Neurol 2003;54:S20–23
- ↵Wilson CM, Grace GM, Munoz DG, et al. Cognitive impairment in sporadic ALS: a pathologic continuum underlying a multisystem disorder. Neurology 2001;57:651–57
- ↵Yoshida M. Amyotrophic lateral sclerosis with dementia: the clinicopathological spectrum. Neuropathology 2004;24:87–102
- ↵Mantovan MC, Baggio L, Dalla Barba G, et al. Memory deficits and retrieval processes in ALS. Eur J Neurol 2003;10:221–27
- ↵Abrahams S, Goldstein LH, Kew JJ, et al. Frontal lobe dysfunction in amyotrophic lateral sclerosis. A PET study. Brain 1996;119:2105–20
- ↵Bowen BC, Pattany PM, Bradley WG, et al. MR imaging and localized proton spectroscopy of the precentral gyrus in amyotrophic lateral sclerosis. AJNR Am J Neuroradiol 2000;21:647–58
- Strong MJ, Grace GM, Orange JB, et al. A prospective study of cognitive impairment in ALS. Neurology 1999;53:1665–70
- Abe K, Takanashi M, Watanabe Y, et al. Decrease in N-acetylaspartate/creatine ratio in the motor area and the frontal lobe in amyotrophic lateral sclerosis. Neuroradiology 2001;43:537–41
- ↵Rule RR, Suhy J, Schuff N, et al. Reduced NAA in motor and non-motor brain regions in amyotrophic lateral sclerosis: a cross-sectional and longitudinal study. Amyotroph Lateral Scler Other Motor Neuron Disord 2004;5:141–49
- ↵
- ↵Miwa H, Kajimoto Y, Nakanishi I, et al. T2-low signal intensity in the cortex in multiple system atrophy. J Neurol Sci. 2003;211:85–88
- ↵Kiernan JA, Hudson AJ. Frontal lobe atrophy in motor neuron diseases. Brain 1994;117:747–57
- ↵Ellis CM, Suckling J, Amaro E Jr., et al. Volumetric analysis reveals corticospinal tract degeneration and extramotor involvement in ALS. Neurology 2001;57:1571–78
- ↵Chang JL, Lomen-Hoerth C, Murphy J, et al. A voxel-based morphometry study of patterns of brain atrophy in ALS and ALS/FTLD. Neurology 2005;65:75–80
- ↵Abrahams S, Goldstein LH, Suckling J, et al. Frontotemporal white matter changes in amyotrophic lateral sclerosis. J Neurol 2005;252:321–31
- ↵De Stefano N, Iannucci G, Sormani MP, et al. MR correlates of cerebral atrophy in patients with multiple sclerosis. J Neurol 2002;249:1072–77
- ↵Ashburner J, Friston KJ. Voxel-based morphometry—the methods. Neuroimage 2000;11:805–21
- ↵Miller RG, Munsat TL, Swash M, et al. Consensus guidelines for the design and implementation of clinical trials in ALS. World Federation of Neurology committee on Research. J Neurol Sci 1999;31:169:2–12
- ↵American Psychiatric Association. Diagnostic and Statistic Manual of Mental Disorders, 4th ed. Washington DC: American Psychiatric Association;1994
- ↵Folstein M F, et al. “Mini-mental state.” A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189–98
- ↵Measso G, Cavarzeran F, Zappalà G, et al. The Mini-Mental State Examination: normative study of an Italian random sample. Dev Neuropsychol 1993;77–85
- ↵Tangalos EG, Smith GE, Ivnik RJ, et al. The Mini-Mental State Examination in general medical practice: clinical utility and acceptance. Mayo Clin Proc 1996;71:829–37
- ↵Neary D, Snowden JS, Gustafson L, et al. Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology 1998;51:1546–54
- ↵Anonymous. The Amyotrophic Lateral Sclerosis Functional Rating Scale. Assessment of activities of daily living in patients with amyotrophic lateral sclerosis. The ALS CNTF treatment study (ACTS) phase I-II Study Group. Arch Neurol 1996;53:141–47
- ↵Great Lakes ALS Study Group. A comparison of muscle strength testing techniques in amyotrophic lateral sclerosis. Neurology 2003;61:1503–07
- ↵Spinnler H, Tognoni G, et al. Standardizzazione e taratura italiana di test neuropsicologici. Ital J Neurol Sci 1987;6 (Suppl 8):47–50
- ↵Peterson LR, Peterson MJ. Short-term repetition of individual verbal items. J Exp Psychol 1959;7:253–61
- ↵Modini S, Mappelli D, Vestri A, et al. Esame Neuropsicologico Breve: una Batteria di Test per lo Screening Neuropsicologico. Milano: Raffaello Cortina Ed.;2003
- ↵Benton AL, Hamsher KS. Multilingual Aphasia Examination. Iowa City: University of Iowa Press;1976
- ↵Carlesimo GA, Caltagirone C, Gainotti G. The Mental Deterioration Battery: normative data, diagnostic reliability and qualitative analyses of cognitive impairment. The Group for the Standardization of the Mental Deterioration Battery. Eur Neurol 1996;36:378–84
- ↵Stroop JR. Studies of interference in serial verbal reactions. J Exp Psychol 1935;18:643–62
- ↵Venturini R, Lombardo Radice M, Imperiali MG. Il Color-Word Test o Test di Stroop. Firenze: Organizzazioni Speciali;1983 .
- ↵Smith A. Symbol Digit Modalities Test. Los Angeles: Western Psychological Services;1982
- ↵Beck AT, Ward CH, Mendelson M, et al. An inventory for measuring depression. Arch Gen Psychiatry 1961;4:561–71
- ↵Smith SM, Zhang Y, Jenkinson M, et al. Accurate, robust and automated longitudinal and cross-sectional brain change analysis. NeuroImage 2002;17:479–89
- ↵Zhang Y, Brady M, Smith S. Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. IEEE Trans Med Imaging 2001;20:45–57
- ↵Friston KJ, Holmes AP, Worsley KJ, et al. Statistical parametric maps in functional imaging: a general linear approach. Hum Brain Mapp 1995;2:189–210
- ↵Good CD, Johnsrude IS, Ashburner J, et al. A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage 2001;14:21–36
- ↵Strong MJ. Progress in clinical neurosciences: the evidence for ALS as a multisystems disorder of limited phenotypic expression. Can J Neurol Sci 2001;28:283–98
- ↵Rudick RA, Fisher E, Lee JC, et al. Use of the brain parenchymal fraction to measure whole brain atrophy in relapsing-remitting MS. Multiple Sclerosis Collaborative Research Group. Neurology 1999 10;53:1698–704
- ↵Gredal O, Pakkenberg H, Karlsborg M, et al. Unchanged total number of neurons in motor cortex and neocortex in amyotrophic lateral sclerosis: a stereological study. J Neurosci Methods 2000;95:171–76
- ↵Paulesu E, Goldacre B, Scifo P, et al. Functional heterogeneity of left inferior frontal cortex as revealed by fMRI. Neuroreport 1997;8:2011–17
- ↵Sowell ER, Thompson PM, Welcome SE, et al. Cortical abnormalities in children and adolescents with attention-deficit hyperactivity disorder. Lancet 2003;22:362:1699–707
- ↵Rubia K, Smith AB, Brammer MJ, et al. Right inferior prefrontal cortex mediates response inhibition while mesial prefrontal cortex is responsible for error detection. Neuroimage 2003;20:351–58
- ↵Piao YS, Wakabayashi K, Kakita A, et al. Neuropathology with clinical correlations of sporadic amyotrophic lateral sclerosis: 102 autopsy cases examined between 1962 and 2000. Brain Pathol 2003;13:10–22
- ↵Thompson SA, Patterson K, Hodges JR. Left/right asymmetry of atrophy in semantic dementia: behavioral-cognitive implications. Neurology 2003;61:1196–203
- ↵Whitwell JL, Josephs KA, Rossor MN, et al. Magnetic resonance imaging signatures of tissue pathology in frontotemporal dementia. Arch Neurol 2005;62:1402–08
- ↵Dolcos F, Rice HJ, Cabeza R. Hemispheric asymmetry and aging: right hemisphere decline or asymmetry reduction. Neurosci Biobehav Rev 2002;26:819–25
- ↵Pennanen C, Testa C, Laakso MP, et al. A voxel based morphometry study on mild cognitive impairment. J Neurol Neurosurg Psychiatry 2005;76:11–14
- ↵Schreiber H, Gaigalat T, Wiedemuth-Catrinescu U, et al. Cognitive function in bulbar- and spinal-onset amyotrophic lateral sclerosis. A longitudinal study in 52 patients. J Neurol 2005;252:772–81
- ↵Kiernan JA, Hudson AJ. Changes in sizes of cortical and lower motor neurons in amyotrophic lateral sclerosis. Brain 1991;114:843–53
- ↵Toft MH, Gredal O, Pakkenberg B. The size distribution of neurons in the motor cortex in amyotrophic lateral sclerosis. J Anat 2005;207:399–407
- ↵Bookstein FL. “Voxel-based morphometry” should not be used with imperfectly registered images. Neuroimage 2001;14:1454–62
- ↵Davatzikos C. Why voxel-based morphometric analysis should be used with great caution when characterizing group differences. Neuroimage 2004;23:17–20
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D.M. Mezzapesa, A. Ceccarelli, F. Dicuonzo, A. Carella, M.F. De Caro, M. Lopez, V. Samarelli, P. Livrea, I.L. Simone
Whole-Brain and Regional Brain Atrophy in Amyotrophic Lateral Sclerosis
American Journal of Neuroradiology Feb 2007, 28 (2) 255-259;
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