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Research ArticleBRAIN

MR Imaging Volumetry of Subcortical Structures and Cerebellar Hemispheres in Temporal Lobe Epilepsy

C.Á. Szabó, J.L. Lancaster, S. Lee, J.-H. Xiong, C. Cook, B.N. Mayes and P.T. Fox
American Journal of Neuroradiology November 2006, 27 (10) 2155-2160;
C.Á. Szabó
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J.L. Lancaster
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S. Lee
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J.-H. Xiong
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C. Cook
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B.N. Mayes
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P.T. Fox
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    Fig 1.

    MR imaging volumetry in a patient with right TLE. Axial view of the right caudate head and thalamus (A) and sagittal image of the right caudate head, thalamus, and cerebellar hemisphere (B).

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    Table 1:

    Demographics of control participants and patients with epilepsy

    Control Participants (n = 20)RTLE (n = 20)LTLE (n = 20)
    Handedness (right-handed)20 (100)20 (100)18 (90)
    Sex (male)9 (45)10 (50)9 (45)
    Age at onset (years)NA14 ± 1313 ± 15
    Duration of epilepsy (years)NA20 ± 1123 ± 10
    GTCSNA11 (55)12 (60)
    GTCS frequency (per year)NA11 ± 1514 ± 20
    MRI Findings
        HANone17 (85)13 (65)
        Nonlesional, no HANone2 (10)4 (20)
        Extrahippocampal lesionsNone1 (5)3 (15)
    Etiology
        UnknownNA97
        Meningitis, abscessNA54
        NeoplasmNA12
        Cortical dysplasiaNA43
        Trauma, infarctNA13
        Cavernous hemangiomaNANone1
    • Note:—TLE indicates temporal lobe epilepsy/resection; GTCS, generalized tonic-clonic seizures; HA, hippocampal atrophy; NA, not applicable. Values (in parentheses are percentages.

    • View popup
    Table 2:

    Volumetric data of control participants and patients with temporal lobe epilepsy

    StructuresSubjects
    Control ParticipantsRight TLELeft TLE
    Hippocampus
        Mean R volume3011 (408)2101 (506)*3078 (501)
        Mean L volume2857 (409)2943 (510)2238 (729)*
        R/L volume ratio1.06 (0.05)‡0.73 (0.22)‡1.47 (0.38)‡
    Amygdala
        Mean R volume1608 (167)1533 (248)1667 (237)
        Mean L volume1497 (186)1610 (185)1440 (400)
        R/L volume ratio1.08 (0.06)‡0.95 (0.16)‡1.24 (0.41)‡
    Thalamus
        Mean R volume6360 (445)5217 (797)*5811 (1056)‡
        Mean L volume6484 (575)5716 (862)*5361 (884)†
        R/L volume ratio0.98 (0.07)0.91 (0.09)‡1.09 (0.11)‡
    Caudate head
        Mean R volume3263 (445)3236 (362)3248 (440)
        Mean L volume3297 (394)3382 (449)3271 (514)
        R/L volume ratio0.99 (0.06)0.96 (0.05)0.99 (0.06)
    Cerebellar hemispheres
        Mean R volume71451 (8589)66890 (9465)66756 (8907)
        Mean L volume72210 (8347)68093 (9164)68134 (9258)
        R/L volume ratio0.99 (0.03)0.98 (0.03)0.99 (0.03)
    • Note:—Volumes expressed as mm3, ( ) indicate standard deviations, R indicates right; L, left; R/L, right divided by left; TLE, temporal lobe epilepsy/resection.

    • * Statistically significant difference between the patient groups and control subjects (p < .0001).

    • † Statistically significant difference between one patient group and control subjects (p < .02).

    • ‡ Statistically significant difference between 2 or 3 groups (p < .05).

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    Table 3:

    Multiple regression analysis for I/C volume ratios with historical factors

    ModelOnset R2 = 0.21Duration R2 = 0.38GTCS R2 = 0.67
    βSETPβSETPβSETP
    Intercept0.717.120.100.92139.766.102.110.0424.698.412.930.01
    Hippocampus0.302.080.150.88−13.0719.38−0.670.502.172.450.880.39
    Amygdala−4.012.60−1.540.13−9.5524.18−0.390.69−12.024.10−2.930.01*
    Thalamus5.982.332.560.01*−62.9321.69−2.900.007*−1.503.17−0.470.64
    Caudate−1.903.06−0.620.531.4428.480.050.967.723.542.180.04*
    Cerebellum0.165.840.030.97−46.9354.24−0.870.39−23.007.30−3.150.008*
    • Note:—GTCS indicates generalized tonic-clonic seizures. All results are expressed as coefficients (β), standard error (SE), T-statistic (T), and P value (P).

    • * Statistical significance.

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American Journal of Neuroradiology: 27 (10)
American Journal of Neuroradiology
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Cite this article
C.Á. Szabó, J.L. Lancaster, S. Lee, J.-H. Xiong, C. Cook, B.N. Mayes, P.T. Fox
MR Imaging Volumetry of Subcortical Structures and Cerebellar Hemispheres in Temporal Lobe Epilepsy
American Journal of Neuroradiology Nov 2006, 27 (10) 2155-2160;

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MR Imaging Volumetry of Subcortical Structures and Cerebellar Hemispheres in Temporal Lobe Epilepsy
C.Á. Szabó, J.L. Lancaster, S. Lee, J.-H. Xiong, C. Cook, B.N. Mayes, P.T. Fox
American Journal of Neuroradiology Nov 2006, 27 (10) 2155-2160;
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