Advertisement

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleBRAIN

Does a Relative Perfusion Measure Predict Cerebral Infarct Size?

Tobias Engelhorn, Arnd Doerfler, Michael Forsting, Gerd Heusch and Rainer Schulz
American Journal of Neuroradiology October 2005, 26 (9) 2218-2223;

Article Figures & Data

Figures

  • Fig 1.
    Fig 1.

    TTC-stained brain sections on the level of the optic chiasm. The white or grayish tissue is unstained and is equivalent to necrotic tissue. The upper section demonstrates a complete infarction of the MCA-supplied territory. Borders of the parietal, temporal, and piriform cortex are outlined as well as the basal ganglia. The middle section demonstrates partial necrosis of the temporal cortex, whereas the lower sections demonstrate complete necrosis.

  • Fig 2.
    Fig 2.

    Relationships between absolute CBF and relative CBFC at 30 minutes post-MCAO and infarct size in groups A (A) and B (B) (expressed as percentage of total brain size). Hkt indicates hematocrit.

Tables

  • TABLE 1:

    Physiologic parameters for animals of group A (MCA occlusion, blood replaced)

    ParameterBaseline30 min Post-MCA Occlusion30 min Post-reperfusion
    AOPmax (mmHg)126 ± 19106 ± 22*101 ± 19*
    AOPmin (mmHg)84 ± 2175 ± 20*68 ± 9*
    Heart rate (beats/min)211 ± 27245 ± 39*246 ± 48*
    Blood pH7.35 ± 0.037.39 ± 0.047.37 ± 0.03
    Pco2 (mmHg)38.9 ± 3.833.0 ± 6.434.4 ± 7.6
    Po2 (mmHg)98.0 ± 19.293.6 ± 23.992.7 ± 15.0
    HCO3− (mM/L)21.1 ± 2.620.9 ± 2.921.2 ± 3.3
    SO2 (%)94.2 ± 3.492.6 ± 3.793.2 ± 2.7
    Hematocrit (%)41.3 ± 3.541.7 ± 5.142.0 ± 6.7
    K+ (mM/L)3.9 ± 0.24.9 ± 0.4*
    Na+ (mM/L)138 ± 1.6136 ± 1.8
    Ca++ (mM/L)1.2 ± 0.081.2 ± 0.07

    • Note.—MCA indicates middle cerebral artery; AOPmax, maximal aortic pressure; AOPmin, minimal aortic pressure.

    • * P < .05 compared to baseline.

  • TABLE 2:

    Physiologic parameters for animals of group B (MCA occlusion, no blood donation)

    ParameterBaseline30 min Post-MCA Occlusion30 min Post-reperfusion
    AOPmax (mmHg)124 ± 10.5112 ± 12*110 ± 10*
    AOPmin (mmHg)89 ± 1178 ± 7*78 ± 14*
    Heart rate (beats/min)210 ± 24214 ± 23*222 ± 19*
    Blood pH7.37 ± 0.057.40 ± 0.037.38 ± 0.01
    Pco2 (mmHg)36.3 ± 1.442.0 ± 3.535.4 ± 1.5
    Po2 (mmHg)105.8 ± 19.2113.1 ± 28.3107.8 ± 16.4
    HCO3− (mM/L)22.0 ± 2.423.6 ± 4.824.8 ± 3.8
    SO2 (%)96.0 ± 1.394.4 ± 1.395.2 ± 2.4
    Hematocrit (%)40.2 ± 4.634.8 ± 5.9*27.1 ± 7.5*
    K+ (mM/L)3.6 ± 0.53.8 ± 0.3*
    Na+ (mM/L)141 ± 2.9137 ± 0.8
    Ca++ (mM/L)1.1 ± 0.081.2 ± 0.1

    • Note.—MCA indicates middle cerebral artery; AOPmax, maximal aortic pressure; AOPmin, minimal aortic pressure.

    • * P < .05 compared to baseline.

  • TABLE 3:

    Cerebral blood flow alterations in animals of group A (MCA occlusion, blood replaced)

    Brain AreasAbsolute CBF (ml/g/min)
    Baseline30 min Post-MCA Occlusion30 min Post-reperfusion
    PCi0.88 ± 0.260.51 ± 0.21*0.42 ± 0.28*
    (98 ± 25%)(46 ± 30%; 58 ± 29%)*(65 ± 39%; 48 ± 23%)*
    TCi0.74 ± 0.240.20 ± 0.15*0.23 ± 0.21*
    (94 ± 23%)(20 ± 18%; 27 ± 20%)*(30 ± 28%; 31 ± 25%)*
    PiCi0.41 ± 0.210.33 ± 0.180.28 ± 0.20
    (94 ± 28%)(63 ± 33%; 81 ± 30%)*(54 ± 27%; 68 ± 27%)*
    BGi0.62 ± 0.190.53 ± 0.220.48 ± 0.18
    (82 ± 30%)62 ± 31%; 77 ± 30%)*(63 ± 30%; 61 ± 30%)*
    PCni0.90 ± 0.371.11 ± 0.720.64 ± 0.47*
    TCni0.79 ± 0.350.97 ± 0.43*0.77 ± 0.27
    PiCni0.44 ± 0.190.53 ± 0.190.53 ± 0.19
    BGni0.85 ± 0.350.86 ± 0.340.66 ± 0.31*

    • Note.—MCA indicates middle cerebral artery; CBF, cerebral blood flow; PCi, infarcted parietal cortex (PCni, noninfarcted); TCi, infarcted temporal cortex (TCni, noninfarcted); PiCi, infarcted piriform cortex (PiCini, noninfarcted); BGi, infarcted basal ganglia (BGni, noninfarcted).

      Values in parentheses show relative CBF in areas of the infarcted hemisphere corresponding to contralateral noninfarcted areas (CBFC) or its baseline blood flow (CBFB), respectively.

    • * P < .05 compared to baseline.

  • TABLE 4:

    Cerebral blood flow alterations in animals of group B (MCA occlusion, no blood donation)

    Brain AreasBaseline30 min Post-MCA Occlusion30 min Post-reperfusion
    PCi1.02 ± 0.330.54 ± 0.30*0.44 ± 0.31*
    (98 ± 22%)(46 ± 27%; 53 ± 32%)*(51 ± 26%; 43 ± 19%)*
    TCi0.86 ± 0.430.27 ± 0.19*0.29 ± 0.20*
    (97 ± 26%)(30 ± 15%; 31 ± 19%)*(32 ± 23%; 34 ± 26%)*
    PiCi0.60 ± 0.280.40 ± 0.200.33 ± 0.17*
    (95 ± 22%)(66 ± 30%; 68 ± 26%)*(52 ± 31%; 55 ± 29%)*
    BGi0.60 ± 0.270.55 ± 0.230.49 ± 0.22
    (98 ± 28%)(55 ± 27%; 69 ± 34%)*(72 ± 36%; 61 ± 27%)*
    PCni1.04 ± 0.341.18 ± 0.500.87 ± 0.39*
    TCni0.88 ± 0.430.88 ± 0.49*0.90 ± 0.48
    PiCni0.63 ± 0.260.60 ± 0.260.62 ± 0.27
    BGni0.82 ± 0.401.00 ± 0.480.67 ± 0.34*

    • Note.—MCA indicates middle cerebral artery; CBF, cerebral blood flow; PCi, infarcted parietal cortex (PCni, noninfarcted); TCi, infarcted temporal cortex (TCni, noninfarcted); PiCi, infarcted piriform cortex (PiCini, noninfarcted); BGi, infarcted basal ganglia (BGni, noninfarcted).

      Values in parentheses show relative CBF in areas of the infarcted hemisphere corresponding to contralateral noninfarcted areas (CBFC) or its baseline blood flow (CBFB), respectively.

    • * P < .05 compared to baseline.

Back to top

In this issue

Advertisement
Print
Download PDF
Email Article
Cite this article
0 Responses
Respond to this article
Bookmark this article
Does a Relative Perfusion Measure Predict Cerebral Infarct Size?
Tobias Engelhorn, Arnd Doerfler, Michael Forsting, Gerd Heusch, Rainer Schulz
American Journal of Neuroradiology Oct 2005, 26 (9) 2218-2223;
del.icio.us logo Twitter logo Facebook logo Mendeley logo

Jump to section

Advertisement