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Research ArticlePEDIATRICS

Cerebral MR Imaging in Uninfected Children Born to HIV-Seropositive Mothers and Perinatally Exposed to Zidovudine

Marc Tardieu, Francis Brunelle, Charles Raybaud, William Ball, Béatrice Barret, Brigitte Pautard, Eric Lachassine, Marie-Jeanne Mayaux and Stéphane Blanche
American Journal of Neuroradiology April 2005, 26 (4) 695-701;
Marc Tardieu
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Francis Brunelle
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Charles Raybaud
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William Ball
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Béatrice Barret
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Brigitte Pautard
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Eric Lachassine
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Marie-Jeanne Mayaux
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Stéphane Blanche
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References

  1. ↵
    Mofenson L, McIntyre J. Advances and research directions in the prevention of mother to child HIV-1 transmission. Lancet 2000;355:2237–2244
    CrossRefPubMedWeb of Science
  2. ↵
    Taylor GP, Low-Beer N. Antiretroviral therapy in pregnancy: a focus on safety. Drug Safety 2001;24:683–702
    CrossRefPubMedWeb of Science
  3. ↵
    Culnane M, Fowler M, Lee SS, et al. Lack of long-term effects of in utero exposure to zidovudine among uninfected children born to HIV-infected women: Pediatric AIDS Clinical Trials Group Protocol 219/076 Teams. JAMA 1999;281:151–157
    CrossRefPubMedWeb of Science
  4. ↵
    Blanche S, Tardieu M, Rustin P, et al. Persistent mitochondrial dysfunction and perinatal exposure to antiretroviral nucleoside analogues. Lancet 1999;354:1084–1089
    CrossRefPubMedWeb of Science
  5. ↵
    The Perinatal Safety review working group. Nucleoside exposure in the children of HIV-infected women receiving antiretroviral drugs: absence of clear evidence for mitochondrial disease in children who died before 5 years of age in five United States cohorts. J Acquir Immune Defic Syndr 2000;25:261–268
  6. ↵
    Barret B, Tardieu M, Rustin P, et al. Mitochondrial dysfunction in HIV uninfected children. AIDS 2003;17:1769–1785
    CrossRefPubMedWeb of Science
  7. ↵
    Blanche S, Rouzioux C, Moscato ML, et al. A prospective study of infants born to women seropositive for human immunodeficiency virus type 1: HIV Infection in Newborns French Collaborative Study Group. N Engl J Med 1989;320:1643–1648
    CrossRefPubMedWeb of Science
  8. ↵
    Nelson JC, Pepe MS. Statistical description of interrater variability in ordinal ratings. Stat Methods Med Res 2000;9:475–496
    Abstract/FREE Full Text
  9. ↵
    Filley CM, Kleinschmidt-Demasters BK. Toxic leukoencephalopathy. N Engl J Med 2001;345:425–432
    CrossRefPubMedWeb of Science
  10. ↵
    Mantovani A, Calamandrei G. Delayed developmental effects following prenatal exposure to drugs. Curr Pharm Des 2001;7:859–880
    CrossRefPubMed
  11. ↵
    Wynn HE, Brundage RC, Fletcher CV. Clinical implications of CNS penetration of antiretroviral drugs. CNS Drugs 2002;16:595–609
    CrossRefPubMedWeb of Science
  12. ↵
    Brinkman K, Ter Hofstede HJ, Burger DM, Smeitink JA, Koopmans PP. Adverse effect of reverse transcriptase inhibitors: mitochondrial toxicity as a common path way. AIDS 1998;12:1735–1744
    CrossRefPubMedWeb of Science
  13. ↵
    Church JA, Mitchell WG, Gonzalez-Gomez I, et al. Mitochondrial DNA depletion, near fatal metabolic acidosis and liver failure in an HIV infected child treated with combination antiretroviral therapy. J Pediatr 2001;138:748–751
    CrossRefPubMedWeb of Science
  14. ↵
    Loutfy MR, Walmsley SL. Treatment of HIV infection in pregnant women: antiretroviral management options. Drugs 2004;64:471–488
    CrossRefPubMedWeb of Science
  15. ↵
    Venerosi A, Calamendrei G, Alleva E. Animal models of antiHIV drugs exposure during pregnancy: effect on neurobehavioral development. Prog Neuropsychopharmacol Biol Psychiatry 2002;26:747–761
    CrossRefPubMed
  16. ↵
    Gerschenson M, Erhart SW, Paik CY, et al. Fetal mitochondrial heart and skeletal muscle damage in Erythrocebus patas monkeys exposed in utero to 3′-azido-3′-deoxythymidine. AIDS Res Hum Retroviruses 2000;16:635–644
    CrossRefPubMedWeb of Science
  17. ↵
    Ewings EL, Gerschenson M, St Claire MC, et al. Genotoxic and functional consequences of transplacental zidovudine exposure in fetal monkey brain mitochondria. J Acquir Immune Defic Syndr 2000;24:100–105
  18. ↵
    Gerschenson M, Nguyen V, Ewings EL, et al. Mitochondrial toxicity in fetal Erythrocebus patas monkeys exposed transplacentally to zidovudine + lamivudine. AIDS Res Huma Retroviruses 2004;20:91–100
    CrossRef
  19. ↵
    Alimenti A, Burdge D, Ogilvie A, et al. Lactic acidemia in HIV infants exposed to perinatal antiretroviral therapy. Pediatr Inf Dis J 2003;22:782–789
    PubMedWeb of Science
  20. ↵
    Shiramizu B, Shikuma KM, Kanemoto L, et al. Placenta and cord blood mitochondrial DNA toxicity in HIV-infected women receiving nucleoside reverse transcriptase inhibitors during pregnancy. J Acquir Immune Defic Syndr 2003;32:370–374
  21. ↵
    Poirier MC, Divi RL, Al-Harti L, et al. Long-term mitochondrial toxicity in HIV-uninfected infants born to HIV-infected mothers. J Acquir Immune Defic Syndr 2003;33:175–183
  22. ↵
    Uusimaa J, Remes AM, Rantala H, et al. Childhood encephalopathies and myopathies: a prospective study in a defined population to assess the frequency of mitochondrial disorders. Pediatrics 2000;105:598–603
    Abstract/FREE Full Text
  23. ↵
    Darin N, Oldfors A, Mosleni AR, Holme E, Tulinius M. The incidence of mitochondrial encephalomyopathies in childhood: clinical features and morphological biochemical and DNA abnormalities. Ann Neurol 2001;49:377–383
    CrossRefPubMedWeb of Science
  24. ↵
    Valanne L, Ketonen L, Majander A, et al. Neuroradiologic findings in children with mitochondrial disorders. AJNR Am J Neuroradiol 1998;19:369–377
    Abstract
  25. Munoz A, Mateos F, Simon R, et al. Mitochondrial diseases in children: neuroradiological and clinical features in 17 patients. Neuroradiology 1999;41:920–928
    CrossRefPubMedWeb of Science
  26. Arii J, Tanabe Y. Leigh syndrome: serial MR imaging and clinical follow-up. AJNR Am J Neuroradiol 2000;21:1502–1509
    Abstract/FREE Full Text
  27. ↵
    de Lonlay-Debeney P, Von Kleist-Retzow JC, Hertz-Pannier L, et al. Cerebral white matter disease in children may be caused by mitochondrial respiratory chain deficiency. J Pediatr 2000;136:209–214
    CrossRefPubMedWeb of Science
  28. ↵
    Ulmer S, Flemming K, Hahn A, Stephani U, Jansen O. Detection of acute cytotoxic changes in progressive neuronal degeneration of childhood with liver disease (Alpers-Huttenlocher syndrome) using diffusion-weighted MRI and MR spectroscopy. J Comput Assist Tomogr 2002;26:641–646
    CrossRefPubMed
  29. ↵
    Abe K, Yoshimura H, Tanaka H, Fujita N, Hikita T, Sakoda S. Comparison of conventional and diffusion-weighted MRI and proton MR spectroscopy in patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like events. Neuroradiology 2004;46:113–7
    CrossRefPubMedWeb of Science
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American Journal of Neuroradiology: 26 (4)
American Journal of Neuroradiology
Vol. 26, Issue 4
1 Apr 2005
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Cite this article
Marc Tardieu, Francis Brunelle, Charles Raybaud, William Ball, Béatrice Barret, Brigitte Pautard, Eric Lachassine, Marie-Jeanne Mayaux, Stéphane Blanche
Cerebral MR Imaging in Uninfected Children Born to HIV-Seropositive Mothers and Perinatally Exposed to Zidovudine
American Journal of Neuroradiology Apr 2005, 26 (4) 695-701;

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Cerebral MR Imaging in Uninfected Children Born to HIV-Seropositive Mothers and Perinatally Exposed to Zidovudine
Marc Tardieu, Francis Brunelle, Charles Raybaud, William Ball, Béatrice Barret, Brigitte Pautard, Eric Lachassine, Marie-Jeanne Mayaux, Stéphane Blanche
American Journal of Neuroradiology Apr 2005, 26 (4) 695-701;
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  • in utero HIV exposure and the early nutritional environment influence neurodevelopment in infants before age three: findings from an evidenced review and meta-analysis
  • Early Antiretroviral Therapy in HIV-Infected Children Is Associated with Diffuse White Matter Structural Abnormality and Corpus Callosum Sparing
  • Effects of Zidovudine Treatment on Heart mRNA Expression and Mitochondrial DNA Copy Number Associated with Alterations in Deoxynucleoside Triphosphate Composition in a Neonatal Rat Model
  • Cranial ultrasound findings in well newborn Ugandan infants
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