Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticlePEDIATRICS

Cerebral MR Imaging in Uninfected Children Born to HIV-Seropositive Mothers and Perinatally Exposed to Zidovudine

Marc Tardieu, Francis Brunelle, Charles Raybaud, William Ball, Béatrice Barret, Brigitte Pautard, Eric Lachassine, Marie-Jeanne Mayaux and Stéphane Blanche
American Journal of Neuroradiology April 2005, 26 (4) 695-701;
Marc Tardieu
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Francis Brunelle
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Charles Raybaud
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
William Ball
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Béatrice Barret
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Brigitte Pautard
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Eric Lachassine
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marie-Jeanne Mayaux
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stéphane Blanche
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • Fig 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 1.

    Image in a boy aged 1 year 5 month with cognitive delay, dystonia, and nystagmus. Results of muscular biopsy established mitochondrial dysfunction. Axial T2-weighted MR image shows diffuse hyperintensity in the periventricular white matter. Note bilateral areas of necrosis.

  • Fig 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 2.

    Image in a boy aged 10 months with severe cognitive delay and repeated seizures. Results of muscular biopsy established mitochondrial dysfunction. Axial FLAIR MR image shows diffuse hyperintensity in the tegmentum pons, basilar pons, and cerebellar vermis.

  • Fig 3.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 3.

    Image in an asymptomatic boy aged 2 years. Axial FLAIR MR image shows hyperintensity in the bilateral periventricular white matter in the posterior trigonal regions.

  • Fig 4.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 4.

    Image in an asymptomatic boy aged 2 years. Axial T2-weighted MR image shows hyperintensity of the brainstem and around the dentate nuclei.

Tables

  • Figures
    • View popup
    TABLE 1:

    Clinical and demographic characteristics of mothers and children

    CharacteristicNo.
    Children49
        Girls20
        Boys29
    Mode of mother’s infection
        Past drug addiction5
        Transfusion1
        Sexual40
    Mother’s geographic origin*
        Europe14
        Sub-Saharan Africa26
        North Africa4
        Other2
    Premature births
        <32 wk0
        <37 wk9
        ≥37 wk40
    Birth weight
        <2500 g11
        ≥2500 g34
        Not known4
    Birth
        Vaginal delivery30
        Cesarean delivery18
        Not known1
    Perinatal prophylactic treatment
        Zidovudine13
        Zidovudine + lamivudine19
        Zidovudine + other2
        Zidovudine + lamivudine + other15
    • * All of the children were born in France.

    • View popup
    TABLE 2:

    Clinical symptoms

    ChildrenNo.
    With mitochondrial dysfunction22
        Cognitive delay15
        Dystonia6
        Nonfebrile seizures6
        Severe malaise3
        Nystagmus2
        Other4
    Without mitochondrial dysfunction27
        Neurologic symptoms14
            Cognitive delay5
            Nonfebrile seizures3
            Repeated febrile seizures2
            Dystonia2
            Nystagmus1
            Acute idiopathic polyneuritis1
            Other2
        Persistent biochemical perturbations7
        Asymptomatic6
    • View popup
    TABLE 3:

    κ Coefficient for the two groups of experts

    Findingκ
    Normal vs abnormal*0.83 ± 0.16
    Diffuse anomaly of the white matter0.93 ± 0.15
    Anomaly of the brainstem0.87 ± 0.14
    Anomaly of the basal ganglia0.78 ± 0.15
    Supratentorial atrophy0.82 ± 0.15
    • Note.—Data are the mean ± standard deviation.

    • * Normal MR images included those showing an isolated anomaly of the posterior white matter.

    • View popup
    TABLE 4:

    Findings observed on MR images

    FindingChildren with Mitochondrial Dysfunction (n = 22)Children without Mitochondrial Dysfunction (n = 27)Total (n = 49)
    Normal61925
    Abnormal16824
        White matter
            Necrosis303
            Diffuse9413
            Posterior415
        Brainstem9514
        Basal ganglia404
        Supratentorial atrophy8210
        Other*123
    • * Vermian atrophy, n = 1; hyperintensity in one cerebellar hemisphere, n = 1; and hyperintensity in both cerebellar hemispheres, n = 1.

PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 26 (4)
American Journal of Neuroradiology
Vol. 26, Issue 4
1 Apr 2005
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Cerebral MR Imaging in Uninfected Children Born to HIV-Seropositive Mothers and Perinatally Exposed to Zidovudine
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
Marc Tardieu, Francis Brunelle, Charles Raybaud, William Ball, Béatrice Barret, Brigitte Pautard, Eric Lachassine, Marie-Jeanne Mayaux, Stéphane Blanche
Cerebral MR Imaging in Uninfected Children Born to HIV-Seropositive Mothers and Perinatally Exposed to Zidovudine
American Journal of Neuroradiology Apr 2005, 26 (4) 695-701;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Cerebral MR Imaging in Uninfected Children Born to HIV-Seropositive Mothers and Perinatally Exposed to Zidovudine
Marc Tardieu, Francis Brunelle, Charles Raybaud, William Ball, Béatrice Barret, Brigitte Pautard, Eric Lachassine, Marie-Jeanne Mayaux, Stéphane Blanche
American Journal of Neuroradiology Apr 2005, 26 (4) 695-701;
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Conclusion
    • Appendix
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • in utero HIV exposure and the early nutritional environment influence neurodevelopment in infants before age three: findings from an evidenced review and meta-analysis
  • Early Antiretroviral Therapy in HIV-Infected Children Is Associated with Diffuse White Matter Structural Abnormality and Corpus Callosum Sparing
  • Effects of Zidovudine Treatment on Heart mRNA Expression and Mitochondrial DNA Copy Number Associated with Alterations in Deoxynucleoside Triphosphate Composition in a Neonatal Rat Model
  • Cranial ultrasound findings in well newborn Ugandan infants
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • SyMRI & MR Fingerprinting in Brainstem Myelination
  • Comparison of Image Quality and Radiation Dose in Pediatric Temporal Bone CT Using Photon-Counting Detector CT and Energy-Integrating Detector CT
  • Dual-Layer Detector CT for PEDS Image Quality
Show more Pediatrics

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire