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Research ArticleBRAIN

Local Tissue Damage Assessed with Statistical Mapping Analysis of Brain Magnetization Transfer Ratio: Relationship with Functional Status of Patients in the Earliest Stage of Multiple Sclerosis

Jean-Philippe Ranjeva, Bertrand Audoin, My Van Au Duong, Danielle Ibarrola, Sylviane Confort-Gouny, Irina Malikova, Elisabeth Soulier, Patrick Viout, André Ali-Chérif, Jean Pelletier and Patrick Cozzone
American Journal of Neuroradiology January 2005, 26 (1) 119-127;
Jean-Philippe Ranjeva
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Bertrand Audoin
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My Van Au Duong
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Danielle Ibarrola
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Sylviane Confort-Gouny
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Irina Malikova
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Elisabeth Soulier
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Patrick Viout
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André Ali-Chérif
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Jean Pelletier
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Patrick Cozzone
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References

  1. ↵
    McDonald WI, Compston A, Edan G, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the international panel on the diagnosis of multiple sclerosis. Ann Neurol 2001;50:121–127
    CrossRefPubMedWeb of Science
  2. ↵
    Miki Y, Grossman RI, Udupa JK, et al. Relapsing-remitting multiple sclerosis: longitudinal analysis of MR images–lack of correlation between changes in T2 lesion volume and clinical findings. Radiology 1999;213:395–399
    CrossRefPubMedWeb of Science
  3. ↵
    Nijeholt GJ, van Walderveen MA, Castelijns JA, et al. Brain and spinal cord abnormalities in multiple sclerosis: correlation between MRI parameters, clinical subtypes and symptoms. Brain 1998;121:687–697
    Abstract/FREE Full Text
  4. ↵
    Reddy H, Narayanan S, Arnoutelis R, et al. Evidence for adaptive functional changes in the cerebral cortex with axonal injury from multiple sclerosis. Brain 2000;123:2314–2320
    Abstract/FREE Full Text
  5. ↵
    Filippi M, Rocca MA, Falini A, et al. Correlations between structural CNS damage and functional MRI changes in primary progressive MS. Neuroimage 2002;15:537–546
    CrossRefPubMedWeb of Science
  6. ↵
    Rocca MA, Mezzapesa DM, Falini A, et al. Evidence for axonal pathology and adaptive cortical reorganization in patients at presentation with clinically isolated syndromes suggestive of multiple sclerosis. Neuroimage 2003;18:847–855
    CrossRefPubMedWeb of Science
  7. ↵
    Audoin B, Ibarrola D, Ranjeva J, et al. Compensatory cortical activation observed by fMRI during a cognitive task at the earliest stage of MS. Hum Brain Mapp 2003;20:51–58
    CrossRefPubMedWeb of Science
  8. ↵
    Rovaris M, Agosta F, Sormani MP, et al. Conventional and magnetization transfer MRI predictors of clinical multiple sclerosis evolution: a medium-term follow-up study. Brain 2003;126:2323–2332
    Abstract/FREE Full Text
  9. ↵
    Kalkers NF, Hintzen RQ, van Waesberghe JH, et al. Magnetization transfer histogram parameters reflect all dimensions of MS pathology, including atrophy. J Neurol Sci 2001;184:155–162
    CrossRefPubMedWeb of Science
  10. ↵
    Charil A, Zijdenbos AP, Taylor J, et al. Statistical mapping analysis of lesion location and neurological disability in multiple sclerosis: application to 452 patient data sets. Neuroimage 2003;19:532–544
    CrossRefPubMedWeb of Science
  11. ↵
    Sailer M, Fischl B, Salat D, et al. Focal thinning of the cerebral cortex in multiple sclerosis. Brain 2003;126:1734–1744
    Abstract/FREE Full Text
  12. ↵
    Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an Expanded Disability Status Scale (EDSS). Neurology 1983;33:1444–1452
    Abstract/FREE Full Text
  13. ↵
    Cutter GR, Baier ML, Rudick RA, et al. Development of a multiple sclerosis functional composite as a clinical trial outcome measure. Brain 1999;122:871–882
    Abstract/FREE Full Text
  14. ↵
    Fischer JS, Rudick RA, Cutter GR, et al. The Multiple Sclerosis Functional Composite Measure (MSFC): an integrated approach to MS clinical outcome assessment. National MS Society Clinical Outcomes Assessment Task Force. Mult Scler 1999;5:244–250
    Abstract/FREE Full Text
  15. ↵
    Ashburner J, Friston K. Voxel-based morphometry: the methods. Neuroimage 2000;11:805–821
    CrossRefPubMedWeb of Science
  16. ↵
    Good CD, Johnsrude IS, Ashburner J, et al. A voxel-based morphometric study of aging in 465 normal adult human brains. Neuroimage 2001;14:21–36
    CrossRefPubMedWeb of Science
  17. ↵
    Friston KJ, Holmes AP, Poline JB, et al. Analysis of fMRI time-series revisited. Neuroimage 1995;2:45–53
    CrossRefPubMedWeb of Science
  18. ↵
    Friston KJ, Holmes AP, Price CJ, et al. Multisubject fMRI studies and conjunction analyses. Neuroimage 1999;10:385–396
    CrossRefPubMedWeb of Science
  19. ↵
    Rugg-Gunn FJ, Eriksson SH, Boulby PA, et al. Magnetization transfer imaging in focal epilepsy. Neurology 2003;60:1638–1645
    Abstract/FREE Full Text
  20. ↵
    Tortorella C, Viti B, Bozzali M, et al. A magnetization transfer histogram study of normal-appearing brain tissue in MS. Neurology 2000;54:186–193
    Abstract/FREE Full Text
  21. Evangelou N, Esiri MM, Smith S, et al. Quantitative pathological evidence for axonal loss in normal appearing white matter in multiple sclerosis. Ann Neurol 2000;47:391–395
    CrossRefPubMedWeb of Science
  22. Allen IV, McKeown SR. A histological, histochemical and biochemical study of the macroscopically normal white matter in multiple sclerosis. J Neurol Sci 1979;41:81–91
    CrossRefPubMedWeb of Science
  23. ↵
    De Stefano N, Matthews P, Filippi M, et al. Evidence of early cortical atrophy in MS: relevance to white matter changes and disability. Neurology 2003;60:1157–1162
    Abstract/FREE Full Text
  24. ↵
    Chard DT, Griffin CM, Barker GJ, et al. Brain atrophy in clinically early relapsing-remitting multiple sclerosis. Brain 2002;125:327–337
    Abstract/FREE Full Text
  25. ↵
    Traboulsee A, Dehmeshki J, Brex PA, et al. Normal-appearing brain tissue MTR histograms in clinically isolated syndromes suggestive of MS. Neurology 2002;59:126–128
    Abstract/FREE Full Text
  26. ↵
    Iannucci G, Tortorella C, Rovaris M, et al. Prognostic value of MR and magnetization transfer imaging findings in patients with clinically isolated syndromes suggestive of multiple sclerosis at presentation. AJNR Am J Neuroradiol 2000;21:1034–1038
    Abstract/FREE Full Text
  27. ↵
    Ranjeva JP, Pelletier J, Confort-Gouny S, et al. MRI/MRS of corpus callosum in patients with clinically isolated syndrome suggestive of multiple sclerosis. Mult Scler 2003;9:554–565
    Abstract/FREE Full Text
  28. ↵
    Talairach J, Tournoux P. Co-Planar Stereotaxic Atlas of the Human Brain. New York: Thieme Medical Publishers, Inc.,1988
  29. ↵
    Kidd D, Barkhof F, McConnell R, et al. Cortical lesions in multiple sclerosis. Brain 1999;122:17–26
    Abstract/FREE Full Text
  30. Peterson J, Bo L, Mork S, et al. Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions. Ann Neurol 2001;50:389–400
    CrossRefPubMedWeb of Science
  31. ↵
    Bo L, Vedeler CA, Nyland HI, et al. Subpial demyelination in the cerebral cortex of multiple sclerosis patients. J Neuropathol Exp Neurol 2003;62:723–732
    PubMedWeb of Science
  32. ↵
    Cifelli A, Arridge M, Jezzard P, et al. Thalamic neurodegeneration in multiple sclerosis. Ann Neurol 2002;52:650–653
    CrossRefPubMedWeb of Science
  33. ↵
    Quarantelli M, Ciarmiello A, Morra VB, et al. Brain tissue volume changes in relapsing-remitting multiple sclerosis: correlation with lesion load. Neuroimage 2003;18:360–366
    CrossRefPubMedWeb of Science
  34. ↵
    Filippi M, Bozzali M, Rovaris M, et al. Evidence for widespread axonal damage at the earliest clinical stage of multiple sclerosis. Brain 2003;126:433–437
    Abstract/FREE Full Text
  35. ↵
    Neumann H. Molecular mechanisms of axonal damage in inflammatory central nervous system diseases. Curr Opin Neurol 2003;16:267–273
    CrossRefPubMedWeb of Science
  36. ↵
    Wylezinska M, Cifelli A, Jezzard P, et al. Thalamic neurodegeneration in relapsing-remitting multiple sclerosis. Neurology 2003;60:1949–1954
    Abstract/FREE Full Text
  37. ↵
    Brownell B, Hughes JT. The distribution of plaques in the cerebrum in multiple sclerosis. J Neurol Neurosurg Psychiatry 1962;25:315–320
  38. ↵
    Lumsden C. The Neuropathology of Multiple Sclerosis. Amsterdam: North-Holland,1970
  39. ↵
    Matthews P, Pioro E, Narayanan S, et al. Assessment of lesion pathology in multiple sclerosis using quantitative MRI morphometry and magnetic resonance spectroscopy. Brain 1996;119:715–722
    Abstract/FREE Full Text
  40. De Stefano N, Matthews PM, Fu L, et al. Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis: results of a longitudinal magnetic resonance spectroscopy study. Brain 1998;121:1469–1477
    Abstract/FREE Full Text
  41. ↵
    Trapp BD, Peterson J, Ransohoff RM, et al. Axonal transection in the lesions of multiple sclerosis. N Engl J Med 1998;338:278–285
    CrossRefPubMedWeb of Science
  42. ↵
    Alexander G, Crutcher M. Functional architecture of basal ganglia circuits: neural substrates of parallel processing. Trends Neurosci 1990;13:166–171
  43. ↵
    Corrigan JD, Hinkeldey NS. Relationships between parts A and B of the Trail Making Test. J Clin Psychol 1987;43:402–409
    CrossRefPubMedWeb of Science
  44. ↵
    Goldstein G, Shelly CH. Statistical and normative studies of the Halstead Neuropsychological Test Battery relevant to a neuropsychiatric hospital setting. Percept Mot Skills 1972;34:603–620
    CrossRefPubMedWeb of Science
  45. ↵
    Swiercinsky DP. Factorial pattern description and comparison of functional abilities in neuropsychological assessment. Percept Mot Skills 1979;48:231–241
    PubMed
  46. ↵
    Baars BJ. The conscious access hypothesis: origins and recent evidence. Trends Cogn Sci 2002;6:47–52
    CrossRefPubMedWeb of Science
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American Journal of Neuroradiology: 26 (1)
American Journal of Neuroradiology
Vol. 26, Issue 1
1 Jan 2005
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Jean-Philippe Ranjeva, Bertrand Audoin, My Van Au Duong, Danielle Ibarrola, Sylviane Confort-Gouny, Irina Malikova, Elisabeth Soulier, Patrick Viout, André Ali-Chérif, Jean Pelletier, Patrick Cozzone
Local Tissue Damage Assessed with Statistical Mapping Analysis of Brain Magnetization Transfer Ratio: Relationship with Functional Status of Patients in the Earliest Stage of Multiple Sclerosis
American Journal of Neuroradiology Jan 2005, 26 (1) 119-127;

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Local Tissue Damage Assessed with Statistical Mapping Analysis of Brain Magnetization Transfer Ratio: Relationship with Functional Status of Patients in the Earliest Stage of Multiple Sclerosis
Jean-Philippe Ranjeva, Bertrand Audoin, My Van Au Duong, Danielle Ibarrola, Sylviane Confort-Gouny, Irina Malikova, Elisabeth Soulier, Patrick Viout, André Ali-Chérif, Jean Pelletier, Patrick Cozzone
American Journal of Neuroradiology Jan 2005, 26 (1) 119-127;
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