Article Figures & Data
Figures
- Fig 1.
Statistical mapping analysis. Patterns of significant MTR abnormalities are observed inside the corpus callosum, bilateral occipitofrontal fascicles, right fornix, right parietal white matter, external capsule, right SLF, right ILF, optica radiata, parietal white matter, right cingulum, bilateral thalamus, bilateral caudate, right insula, and the left BA8.
A, Multiplanar images of MTR decrease observed in patients with CISSMS compared with control subjects.
B, Transverse images of MTR decrease observed in patients with CISSMS compared with control subjects.
- Fig 2.
In patients with CISSMS, significant correlations between MTR and TMTA scores (Spearman rank test, P < .05) are observed inside the bilateral BA4, bilateral BA3, right BA6, left BA8, left frontal white matter, left occipitofrontal fascicles (top row, left to right) and in the left frontal white matter, left occipitofrontal fascicles, body of corpus callosum, bilateral cingulum, bilateral BA40, right lateral sulcus, and right claustrum (bottom row, left to right).
- Fig 3.
In patients with CISSMS, significant correlations between MTR and MSFC scores (Spearman rank test, P < .05) are observed inside right SLF (FLS), right frontal white matter (WM), projections of the anterior corpus callosum (CC), splenium, and left BA40 (left to right).
- Fig 4.
In patients with CISSMS, significant correlations between MTR and PASAT scores (Spearman rank test, P < .05) are observed in the splenium, left BA40, right BA 4, and right SLF.
Tables
Patient No./Age (y) Clinical Syndrome McDonald’s Criteria Months Since Onset Test Scores T2 Lesion Load (cm3) EDSS PASAT MSFC TMTA 1/22 Optic neuritis MS 7 1 30 −1.758 32.66 1.78 2/35 Hemispheric syndrome MS possible 7 0 37 −1.108 34.00 2.36 3/36 Optic neuritis MS 3 1 37 −1.961 19.93 1.48 4/34 Hemispheric syndrome MS 12 0 34 −1.213 39.00 2.36 5/34 Optic neuritis MS 4 0 30 −1.106 14.78 1.78 6/37 Spinal cord syndrome MS possible 5 2 21 −2.093 29.00 1.32 7/27 Optic neuritis MS 5 2 36 −1.330 30.00 1.74 8/25 Optic neuritis MS 4 0 32 −0.631 32.47 2.03 9/25 Brain-stem syndrome MS 6 0 34 −0.377 19.00 1.19 10/36 Hemispheric syndrome MS 6 1 45 −1.082 37.62 5.94 11/22 Spinal cord syndrome MS 3 1 54 0.354 27.19 0.58 12/40 Hemispheric syndrome MS possible 4 0 51 −0.532 49.00 3.38 13/38 Optic neuritis MS 24 1 40 −1.232 39.04 2.20 14/19 Spinal cord syndrome MS 4 1 41 −0.827 25.50 1.02 15/25 Hemispheric syndrome MS 10 0 49 0.224 22.30 0.53 16/22 Spinal cord syndrome MS 6 1 50 0.576 22.12 5.06 17/20 Brain-stem syndrome MS 3 0 48 0.083 35.72 2.59 18/30 Spinal cord syndrome MS possible 7 1 45 0.059 33.37 1.28 - TABLE 2:
Demographics and clinical characteristics of the patients with CISSMS and control subjects
Characteristic Patients (n = 18) Controls (n = 18) Age (y), mean (SD) 29.3 (7) 25.27 (6.3) Educational level (y), mean (SD) 13.1 (2.4) 14.7 (2.10) Gender Female 16 16 Male 2 2 Test Scores, mean (SD) MSFC −0.78 (0.8)* −0.101 (0.60) PASAT 39.7 (8.9)† 48.72 (6.78) Nine-hole peg test (s−1) 4.96 × 10−2 5.25 × 10−2 (0.49 × 10−2) (0.55 × 10−2) 25-foot walking test (s) 4.75 (0.78) 4.39 (0.76) TMTA (s) 30.2 (8.6)* 22.6 (2.6) Stroop (s) 57.8 (9.8) 56.8 (10.6) MADRS 8.9 (3.9) 8.2 (4.2) MFIS 22.5 (13.4) 25.5 (12.4) * P < .05.
† P < .005 (Mann Whitney U test).
Cluster No. k Value Corrected P Value t Value X Y Z Location 1 142 .012 6.70 0 −42 21 CC splenium 2 2112 <.001 6.68 −2 −11 19 CC genu 6.41 −6 −27 7 Left thalamus 6.23 6 −17 16 Right fornix 5.93 0 −6 24 CC body 5.89 8 18 3 Right caudate 5.66 −8 16 10 Left caudate 5.31 22 −16 32 Right OF 5.30 28 −30 24 Right parietal WM 5.21 8 −27 11 Right thalamus 5.17 14 −10 34 Right cingulum 3 50 .040 6.22 36 −17 8 Right insula 4 39 .035 5.86 36 17 −3 Right insula 4.30 38 6 −4 External capsule 5 55 .009 5.69 −24 37 46 Left BA8 6 236 <.001 5.12 28 −37 6 Right optica radiata 5.08 38 −37 6 Right ILF 4.64 34 −44 19 Right SLF 7 34 .049 4.89 −16 −14 36 Left cingulum Note.—CC indicates corpus callosum; OF, occipitofrontal fascicles; WM, white matter.
- TABLE 4:
Spearman rank correlation test between local MTR and functional scores in patients with CISSMS
Correlations Location r Value P Value MTR = f(TMTA) Left BA 4 −0.789 .0011 Right BA 4 −0.643 .0080 Right BA 40 −0.699 .0040 Left BA 39/40 −0.552 .0228 Right thalamus −0.492 .0424 Right BA 3/4 −0.643 .0080 Left BA 3/4 −0.746 .0021 Left BA 8 −0.692 .0043 Right lateral sulcul −0.610 .0119 Right BA 6 −0.507 .0367 Body of corpus callosum −0.700 .0038 Left cingulum −0.674 .0055 Left frontal WM −0.814 .0008 Left OF −0.674 .0055 Right claustrum −0.668 .0059 Right cingulum −0.837 .0006 MTR = f(PASAT) Right BA 4 0.590 .0149 Left BA 40 0.698 .0040 Splenium 0.599 .0136 Right SLF 0.631 .0093 MTR = f(MSFC) Left BA 40 0.657 .0067 Splenium 0.527 .0297 Right SLF 0.515 .0337 Right frontal WM 0.676 .0053 Anterior corpus callosum 0.536 .0266 Note.—OF indicates occipitofrontal fascicles; WM, white matter.
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