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Research ArticlePEDIATRICS

MR Imaging in the Diagnosis of Desmoplastic Infantile Tumor: Retrospective Study of Six Cases

Guillaume Trehan, Helene Bruge, Matthieu Vinchon, Chadi Khalil, Marie M. Ruchoux, Patrick Dhellemmes and Gustavo Soto Ares
American Journal of Neuroradiology June 2004, 25 (6) 1028-1033;
Guillaume Trehan
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Helene Bruge
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Matthieu Vinchon
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Chadi Khalil
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Marie M. Ruchoux
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Patrick Dhellemmes
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Gustavo Soto Ares
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    Fig 1.

    Case 1. Axial T1- (A), axial T2- (B), and axial postgadolinium T1-weighted (C) MR images show a large supratentorial and heterogeneous tumor involving the frontotemporoparietal lobes with a major mass effect. The solid part of the tumor has two components. The peripheral part is heterogeneous and moderately hyperintense on T1-weighted images and shows low signal intensity on T2-weighted images suggestive of intratumoral bleeding; the medial part is enhanced after gadolinium injection. The posterior cystic part of the lesion is of high signal intensity on T1- and T2-weighted images, which is compatible with a recent bleeding episode. Radiologic appearance is suggestive of a malignant lesion.

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    Fig 2.

    Case 3. Axial postgadolinium T1- (A), coronal postgadolinium T1- (B), and axial T2-weighted (C) MR images show a typically large supratentorial mass with a peripheral solid and a deep cystic component. The peripheral solid component is enhanced after gadolinium injection (A and B) and is associated with a meningeal thickening and enhancement. Note the major mass effect on the midline and the ventricles.

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    Fig 3.

    Standard hematoxylin coloration (magnification ×250) shows the fusiform astrocytic cells forming a dense fascicle pattern.

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    Fig 4.

    DIG with marked neurofilament immunostain (magnification ×400) due to the presence of neural cells (black arrow).

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  • Clinical findings

    FindingCase (No.)
    123456
    Sex/age (mo)M/5M/39M/5F/2.5F/48M/5
    Symptom duration3 wk1 mo2 mo2.5 mo2 mo0
    Increasing head circumferenceYNNYNN
    SeizuresNYYNNN
    Increased ICPYNNNYN
    Other symptomsSkull deformation. . .. . .. . .Visual field. . .
    TreatmentTotal excisionTotal excisionSubtotal excisionTotal excisionPartial excisionTotal excision
    Follow-up18 mo, norm dvpt, upper limb paralysis14 mo, norm dvpt3 y 6 mo, norm dvpt, dysphasia24 mo norm dvpt13 mo death7 y, norm dvpt
    • Note.—Yes (Y), no (N), normal development (norm dvpt).

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American Journal of Neuroradiology: 25 (6)
American Journal of Neuroradiology
Vol. 25, Issue 6
1 Jun 2004
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Cite this article
Guillaume Trehan, Helene Bruge, Matthieu Vinchon, Chadi Khalil, Marie M. Ruchoux, Patrick Dhellemmes, Gustavo Soto Ares
MR Imaging in the Diagnosis of Desmoplastic Infantile Tumor: Retrospective Study of Six Cases
American Journal of Neuroradiology Jun 2004, 25 (6) 1028-1033;

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MR Imaging in the Diagnosis of Desmoplastic Infantile Tumor: Retrospective Study of Six Cases
Guillaume Trehan, Helene Bruge, Matthieu Vinchon, Chadi Khalil, Marie M. Ruchoux, Patrick Dhellemmes, Gustavo Soto Ares
American Journal of Neuroradiology Jun 2004, 25 (6) 1028-1033;
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