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Improved Turnaround Times | Median time to first decision: 12 days

Research ArticleBrain

Acute Methotrexate Neurotoxicity: Findings on Diffusion-Weighted Imaging and Correlation with Clinical Outcome

Nancy Rollins, Naomi Winick, Robert Bash and Timothy Booth
American Journal of Neuroradiology November 2004, 25 (10) 1688-1695;
Nancy Rollins
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Naomi Winick
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Robert Bash
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Timothy Booth
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  • Fig 1.
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    Fig 1.

    Patient 1 presented with nonfluent aphasia and bilateral upper-extremity weakness.

    A, Axial DW image is limited by motion artifact. Areas of restricted diffusion in the centrum semiovale account for the arm weakness. Nonfluent aphasia may be subcortical.

    B, Axial FLAIR image obtained 39 months later shows minimal abnormal T2 signal intensity consistent with demyelination. There are no residual neurologic deficits.

  • Fig 2.
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    Fig 2.

    Patient 2 presented with nonfluent aphasia and left-sided hemiparesis and hemisensory loss.

    A, Axial ADC map shows asymmetric areas of restricted diffusion in the centrum semiovale. Image distortion is due to orthodontia. Right-sided lesion is correlated with left-sided hemiparesis, whereas the left-sided white matter lesion was not accompanied by a motor deficit.

    B, Axial FLAIR image obtained 8 weeks later shows large, confluent areas of presumed demyelination in the right centrum semiovale similar in size to the DW abnormality. Left cerebral white matter lesion that was clinically unapparent at presentation is smaller than the white matter lesion associated with neurologic deficit at presentation. Neurologic deficits had resolved.

  • Fig 3.
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    Fig 3.

    Patient 3 had steroid-induced IDDM and presented during induction. Initial strokelike event was associated with aphasia and right hemiparesis and hemisensory loss, which resolved. Second event occurred 8 weeks later and was associated with aphasia, left hemiparesis, and focal seizure, all of which resolved.

    A and B, DW image (A) and ADC map (B) at initial presentation show large areas of restricted diffusion in the centrum semiovale (arrows). Bilateral diffusion abnormalities were associated with unilateral hemimotor-sensory deficit.

    C and D, Axial FLAIR images obtained 8 weeks later shows extensive presumed demyelination in deep white matter. Note absence of abnormal signal intensity in the right parietal region.

    E and F, Axial DW image (E) and ADC map (F) show restricted diffusion in the right parietal cortex and subcortical white matter. Diffusion abnormalities were correlated with left hemiparesis and left focal seizure. Hyperintensity in the left anterior centrum semiovale (arrow in E) is due to T2 shine-through; ADC map shows a corresponding area of hyperintensity (arrow in F).

    G, Axial FLAIR image obatined 28 months later when the patient was asymptomatic shows more-extensive white matter abnormalities. Note absence of gliosis in the right parietal region.

  • Fig 4.
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    Fig 4.

    Patient 4 presented with nonfluent aphasia and alternating fluctuating hemiparesis and left facial droop.

    A and B, Axial DW images show asymmetric regions of restricted diffusion in the anterior centrum semiovale that do not explain the motor neurologic deficits.

    C, Follow-up MR image obtained 39 months later shows minimal scattered demyelination. The patient was neurologically intact.

  • Fig 5.
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    Fig 5.

    Patient 5 presented with nonfluent aphasia, mild right facial weakness, right hemiparesis, and left-arm sensory deficit.

    A, DW image shows a small area of restricted diffusion with the left precentral region (arrow) that does not fully explain the neurologic deficits.

    B, Axial FLAIR image obtained 13 months later shows no signal-intensity abnormality in the left precentral region.

    C, Image shows small areas of presumed demyelination in the centrum semiovale. The patient was neurologically intact.

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    TABLE 2:

    MR findings in acute MTX neurotoxicity

    Patient/AgeSymptomsSite of Restricted DiffusionInterval to Next MR StudyT2 Abnormalities on Next MR StudyClinical Follow-Up (mo)
    1/15/FAphasia, bilateral arm weakness R < LBilateral posterior centrum semiovale13 moMinimal involvement of R cenetrum semiovale25
    2/14/MAphasia, L upper-extremity weaknessBilateral posterior centrum semiovale6 wkAsymmetric involvement of centrum semiovale R > L9
    3/15/F
        InitialAphasia, R-sided weaknessBilateral posterior centrum semiovale8 wkBilateral centrum semiovale42
        RecurrenceRecurrence of aphasia, L hemiparesis, and focal seizure 8 wk laterR parietal cortex and white matter28 moProgressive involvement of centrum semiovale, normal cortex
    4/14/MAphasia, fluctuating bilateral hemiparesis, L facial droopBilateral asymmetric anterior centrum semiovale39 moMinimal scattered involvement of bilateral centrum semiovale49
    5/12/FAphasia, R-sided weakness, mild R facial droopL precentral subcortical white matter13 moMinimal scattered involvement of bilateral centrum semiovale23
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American Journal of Neuroradiology: 25 (10)
American Journal of Neuroradiology
Vol. 25, Issue 10
1 Nov 2004
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Nancy Rollins, Naomi Winick, Robert Bash, Timothy Booth
Acute Methotrexate Neurotoxicity: Findings on Diffusion-Weighted Imaging and Correlation with Clinical Outcome
American Journal of Neuroradiology Nov 2004, 25 (10) 1688-1695;

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Acute Methotrexate Neurotoxicity: Findings on Diffusion-Weighted Imaging and Correlation with Clinical Outcome
Nancy Rollins, Naomi Winick, Robert Bash, Timothy Booth
American Journal of Neuroradiology Nov 2004, 25 (10) 1688-1695;
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