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Improved Turnaround Times | Median time to first decision: 12 days

Research ArticleNeurointervention

Computational Approach to Quantifying Hemodynamic Forces in Giant Cerebral Aneurysms

Liang-Der Jou, Christopher M. Quick, William L. Young, Michael T. Lawton, Randall Higashida, Alastair Martin and David Saloner
American Journal of Neuroradiology October 2003, 24 (9) 1804-1810;
Liang-Der Jou
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Christopher M. Quick
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William L. Young
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Michael T. Lawton
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Randall Higashida
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Alastair Martin
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David Saloner
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Figures

  • Fig 1.
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    Fig 1.

    Computational fluid dynamics results in a schematic model of a giant basilar aneurysm.

    A, Coronal projection of the schematic geometry shows a spherical aneurysm just distal to the vertebral junction.

    B, Equal inlet flow in both vertebral arteries. Velocity field in the coronal plane shows the highest velocities in the center of the vessels and slow recirculating flow (blue) on the walls of the aneurysm. Also shown is a transverse plane through the center of the aneurysm (arrow).

    C, Simulated occlusion of one vertebral artery (arrowhead). Velocity stream is diverted to the aneurysm wall (arrow) ipsilateral to the simulated occluded vessel.

  • Fig 2.
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    Fig 2.

    A and B, Phase-contrast MR images acquired transverse to the carotid (A) and basilar (B) arteries.

    C, Velocity waveform shows mean flow through the basilar artery during one cardiac cycle.

  • Fig 3.
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    Fig 3.

    Computational fluid dynamics results in the patient-specific geometry with velocity boundary conditions as determined in vivo by MR velocimetry.

    A, Calculated velocity field (m/s). Note highly asymmetric flow secondary to near occlusion of the right vertebral artery. There is a large region of slow recirulating flow (blue) in the pouch of the aneurysm.

    B, Calculated distribution of pressure (range from 0 to 150 pascal). The pressure distribution has no regions of pronounced increased pressure, with a smooth drop from inlet to outlet vessels.

  • Fig 4.
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    Fig 4.

    Calculated wall shear stress along the lateral side of the vertebrobasilar system shown in Fig 1. The variable S is the distance measured along the outside wall, which includes the vertebral artery to be occluded. Shear stress is shown for symmetric inflow (solid line) and for simulated occlusion of the ipsilateral vertebral artery (dotted line).

  • Fig 5.
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    Fig 5.

    Coronal maximum intensity projection of a contrast-enhanced MR angiographic study in a patient with a fusiform basilar aneurysm. The vertebral and basilar arteries have been selected from the full data set. Also noted is a stenosis of the right vertebral artery.

  • Fig 6.
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    Fig 6.

    Plots of changes in velocity (dashed line) and volume flow (solid line) that are predicted by theory in response to increasing stenosis. Note that conservation of flow predicts a velocity increase for relatively small increases in stenosis, but that volume flow only starts to drop appreciably once the stenosis becomes hemodynamically limiting (ie, after the stenosis exceeds approximately 70%).

  • Fig 7.
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    Fig 7.

    Computational fluid dynamics results in the patient-specific geometry assuming that there is an equal flow rate through the vertebral arteries.

    A, Calculated velocity field (m/s). A high velocity jet is predicted through the stenotic vertebral artery impinging on the wall of the aneurysm. Flow reciruclation is noted on both sides of the jet.

    B, Calculated distribution of pressure (range from 0 to 150 pascal). The pressure distribution shows a region of pronounced elevation of pressure on the outside wall of the aneurysm.

  • Fig 8.
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    Fig 8.

    Wall shear values calculated for the patient-specific geometry assuming equal flow rate through the vertebral arteries. Wall shear stress ranges from 0 to 5 pascal. A region of high wall shear stress is predicted adjacent to the site of impingement of the flow jet noted in Fig 7A.

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American Journal of Neuroradiology: 24 (9)
American Journal of Neuroradiology
Vol. 24, Issue 9
1 Oct 2003
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Computational Approach to Quantifying Hemodynamic Forces in Giant Cerebral Aneurysms
Liang-Der Jou, Christopher M. Quick, William L. Young, Michael T. Lawton, Randall Higashida, Alastair Martin, David Saloner
American Journal of Neuroradiology Oct 2003, 24 (9) 1804-1810;
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Liang-Der Jou, Christopher M. Quick, William L. Young, Michael T. Lawton, Randall Higashida, Alastair Martin, David Saloner
Computational Approach to Quantifying Hemodynamic Forces in Giant Cerebral Aneurysms
American Journal of Neuroradiology Oct 2003, 24 (9) 1804-1810;

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