Research ArticleBRAIN
Frequency of Subclinical Lacunar Infarcts in Ischemic Leukoaraiosis and Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
Michael O’Sullivan, Philip M. Rich, Thomas R. Barrick, Christopher A. Clark and Hugh S. Markus
American Journal of Neuroradiology August 2003, 24 (7) 1348-1354;
Michael O’Sullivan
aDivision of Clinical Neuroscience, St. George’s Hospital Medical School, London, England
Philip M. Rich
bDepartment of Neuroradiology, St. George’s and Atkinson Morley’s Hospitals, London, England
Thomas R. Barrick
aDivision of Clinical Neuroscience, St. George’s Hospital Medical School, London, England
Christopher A. Clark
aDivision of Clinical Neuroscience, St. George’s Hospital Medical School, London, England
Hugh S. Markus
aDivision of Clinical Neuroscience, St. George’s Hospital Medical School, London, England

References
- ↵Roman GC Tatemichi TK, Erkinjuntti T, et al. Vascular dementia: diagnostic criteria for research studies: report of the NINDS-AIREN International Workshop. Neurology 1993;43:250–260
- ↵Babikian V, Ropper AH. Binswanger’s disease: a review. Stroke 1987;18:2–12
- ↵Hachinski VC, Potter P, Merskey H. Leuko-araiosis. Arch Neurol 1987;44:21–23
- ↵Jones DK, Lythgoe D, Horsfield MA, Simmons A, Williams SC, Markus HS. Characterization of white matter damage in ischemic leukoaraiosis with diffusion tensor MRI. Stroke 1999;30:393–397
- ↵Dichgans M, Mayer M, Uttner I, et al. The phenotypic spectrum of CADASIL: clinical findings in 102 cases. Ann Neurol 1998;44:731–739
- ↵Chabriat H, Levy C, Taillia H, et al. Patterns of MRI lesions in CADASIL. Neurology 1998;51:452–457
- ↵Okeda R, Arima K, Kawai M. Arterial changes in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) in relation to pathogenesis of diffuse myelin loss of cerebral white matter: examination of cerebral medullary arteries by reconstruction of serial sections of an autopsy case. Stroke 2002;33:2565–2569
- ↵Miller DH, Barkhof F, Nauta JJ. Gadolinium enhancement increases the sensitivity of MRI in detecting disease activity in multiple sclerosis. Brain 1993;116:1077–1094
- ↵Miller DH, Albert PS, Barkhof F, et al. Guidelines for the use of magnetic resonance techniques in monitoring the treatment of multiple sclerosis: US National MS Society Task Force. Ann Neurol 1996;39:6–16
- ↵Molyneux PD, Filippi M, Barkhof F, et al. Correlations between monthly enhanced MRI lesion rate and changes in T2 lesion volume in multiple sclerosis. Ann Neurol 1998;43:332–339
- ↵Kappos L, Moeri D, Radue EW, et al. Predictive value of gadolinium-enhanced magnetic resonance imaging for relapse rate and changes in disability or impairment in multiple sclerosis: a meta-analysis: Gadolinium MRI Meta-analysis Group. Lancet 1999;353:964–969
- ↵Warach S, Gaa J, Siewert B, Wielpolski P, Edelman RR. Acute human stroke studied by whole brain echo planar diffusion-weighted magnetic resonance imaging. Ann Neurol 1995;37:231–241
- ↵Singer MB, Chong J, Lu D, Schonewille WJ, Tuhrim S, Atlas SW. Diffusion-weighted MRI in acute subcortical infarction. Stroke 1998;29:133–136
- ↵Choi SH, Na DL, Chung CS, Lee KH, Na DG, Adair JC. Diffusion-weighted MRI in vascular dementia. Neurology 2000;54:83–89
- ↵Bamford J, Sandercock P, Dennis M, Burn J, Warlow C. Classification and natural history of clinically identifiable subtypes of cerebral infarction. Lancet 1991;337:1521–1526
- ↵Fazekas F, Kleinert R, Offenbacher H, et al. Pathologic correlates of incidental MRI white matter signal hyperintensities. Neurology 1993;43:1683–1689
- ↵Joutel A, Vahedi K, Corpechot C. Strong clustering and stereotyped nature of Notch3 mutations in CADASIL patients. Lancet 1997;350:1511–1515
- ↵Jones DK, Horsfield MA, Simmons A. Optimal strategies for measuring diffusion in anisotropic systems by magnetic resonance imaging. Magn Reson Med 1999;42:515–525
- ↵Burdette JH, Elster AD, Ricci PE. Acute cerebral infarction: quantification of spin-density and T2 shine-through phenomena on diffusion-weighted MR images. Radiology 1999;212:333–339
- ↵Helenius J, Soinne L, Salonen O, Kaste M, Tatlisumak T. Leukoaraiosis, ischemic stroke, and normal white matter on diffusion-weighted MRI. Stroke 2002;33:45–50
- ↵O’Sullivan M, Jarosz JM, Martin RJ, Deasy N, Powell JF, Markus HS. MRI hyperintensities of the temporal lobe and external capsule in patients with CADASIL. Neurology 2001;56:628–634
- ↵Markus HS, Martin RJ, Simpson MA, et al. Diagnostic strategies in CADASIL. Neurology 2002;59:1134–1138
- ↵Wittes J, Lakatos E, Probstfield J. Surrogate endpoints in clinical trials: cardiovascular diseases. Stat Med 1989;8:415–425
- ↵Schlaug G, Siewert B, Benfield A, Edelman RR, Warach S. Time course of the apparent diffusion coefficient (ADC) abnormality in human stroke. Neurology 1997;49:113–119
- ↵
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Michael O’Sullivan, Philip M. Rich, Thomas R. Barrick, Christopher A. Clark, Hugh S. Markus
Frequency of Subclinical Lacunar Infarcts in Ischemic Leukoaraiosis and Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
American Journal of Neuroradiology Aug 2003, 24 (7) 1348-1354;
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Frequency of Subclinical Lacunar Infarcts in Ischemic Leukoaraiosis and Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
Michael O’Sullivan, Philip M. Rich, Thomas R. Barrick, Christopher A. Clark, Hugh S. Markus
American Journal of Neuroradiology Aug 2003, 24 (7) 1348-1354;
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