Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleBRAIN

Frequency of Subclinical Lacunar Infarcts in Ischemic Leukoaraiosis and Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy

Michael O’Sullivan, Philip M. Rich, Thomas R. Barrick, Christopher A. Clark and Hugh S. Markus
American Journal of Neuroradiology August 2003, 24 (7) 1348-1354;
Michael O’Sullivan
aDivision of Clinical Neuroscience, St. George’s Hospital Medical School, London, England
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Philip M. Rich
bDepartment of Neuroradiology, St. George’s and Atkinson Morley’s Hospitals, London, England
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas R. Barrick
aDivision of Clinical Neuroscience, St. George’s Hospital Medical School, London, England
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christopher A. Clark
aDivision of Clinical Neuroscience, St. George’s Hospital Medical School, London, England
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hugh S. Markus
aDivision of Clinical Neuroscience, St. George’s Hospital Medical School, London, England
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • Fig 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 1.

    Examples of recent ischemic lesions and T2 shine-through effect. For recent lesions, high signal intensity is seen on the diffusion-weighted images (left), and corresponding reductions of diffusivity are seen on the ADC maps (right, arrows).

    A, A recent asymptomatic ischemic lesions is seen in the left centrum semiovale in a patient with ischemic leukoaraiosis.

    B, A recent asymptomatic ischemic lesions is seen in the left cerebellar hemisphere in a patient with CADASIL.

    C, Two areas of hyperintensity are seen on the diffusion-weighted images of a different patient (left) and are found to correspond with increased ADC values (right, arrows), indicating that these are chronic lesions.

Tables

  • Figures
    • View popup
    TABLE 1:

    Clinical and radiologic findings in the two study groups

    Ischemic Leukoaraiosis (n = 50)CADASIL (n = 19)
    Clinical characteristics
     Age (yr ± SD)69.8 ± 9.8 (range, 47–86)47.3 ± 12.2 (range, 21–69)
     Males32 (64%)8 (42%)
     Hypertension40 (80%)1 (5%)
     Diabetes mellitus6 (12%)None
     Anti-platelet therapy46 (92%)15 (79%)
     Anti-coagulant therapyNone2 (10%)
    Global cognitive function
     MMSE score 28–3025 (50%)16 (84%)
     MMSE score 24–2714 (28%)3 (16%)
     MMSE score <247 (14%)None
    MR imaging findings
     Confluent changes (score of 3 on Fazekas scale)43 (86%)17 (90%)
    • Note.—CADASIL indicates cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy; MMSE, Mini-Mental State Examination.

    • View popup
    TABLE 2:

    Clinical characteristics of patients with asymptomatic new lesions

    Age (yr)/GenderClinical DetailsDiffusion-weighted Imaging
    75 M1979, left hemiparesis, dysarthria; 1992, 1998, episodes of unexplained loss of consciousness, hypertension; no symptoms for 8 months before MR imaging; MMSE score, 29Left centrum semiovale infarct
    55 M1995, right hemiparesis; 1999, right hemiparesis, dysarthria; no symptoms for 7 months before MR imaging; gait apraxia, pseudobulbar palsy, MMSE score, 25Right frontal subcortical lacunar infarct
    74 M1991, right hemiparesis; 1998, episode of confusion; 1999, right hemiparesis and sensory loss (120 days before MR imaging); hypertension, smoker, MMSE score, 26Left lentiform nucleus lacunar infarct
    65 M2001, right hemiparesis (97 days before MR imaging), hypertension; 1991, myocardial infarction, chronic renal failure; MMSE score, 30Right lentiform nucleus lacunar infarct
    53 MCADASIL; 1980s, right hemisensory disturbance, migraine; 1999, encephalopathy; no symptoms for 10 months before MR imaging; MMSE score, 30Left centrum semiovale infarct
    49 MCADASIL; multiple events affecting both hands (weakness, numbness), dysarthria; no symptoms for 4 months before MR imaging; MMSE score, 28Left cerebellar hemisphere lacunar infarct
    • Note.—M indicates male; MMSE, Mini-Mental State Examination; CADASIL, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy.

PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 24 (7)
American Journal of Neuroradiology
Vol. 24, Issue 7
1 Aug 2003
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Frequency of Subclinical Lacunar Infarcts in Ischemic Leukoaraiosis and Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
Michael O’Sullivan, Philip M. Rich, Thomas R. Barrick, Christopher A. Clark, Hugh S. Markus
Frequency of Subclinical Lacunar Infarcts in Ischemic Leukoaraiosis and Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
American Journal of Neuroradiology Aug 2003, 24 (7) 1348-1354;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Frequency of Subclinical Lacunar Infarcts in Ischemic Leukoaraiosis and Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
Michael O’Sullivan, Philip M. Rich, Thomas R. Barrick, Christopher A. Clark, Hugh S. Markus
American Journal of Neuroradiology Aug 2003, 24 (7) 1348-1354;
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Conclusion
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • The role of small diffusion-weighted imaging lesions in cerebral small vessel disease
  • White Matter Hyperintensities and Their Penumbra Lie Along a Continuum of Injury in the Aging Brain
  • Lacunar lesions are independently associated with disability and cognitive impairment in CADASIL
  • Characteristics of CADASIL in Korea: A novel cysteine-sparing Notch3 mutation
  • What causes lacunar stroke?
  • Are multiple acute small subcortical infarctions caused by embolic mechanisms?
  • A Two-Year Clinical Follow-Up Study in 80 CADASIL Subjects: Progression Patterns and Implications for Clinical Trials
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Optimal MRI Sequence for Identifying Occlusion Location in Acute Stroke: Which Value of Time-Resolved Contrast-Enhanced MRA?
  • Evaluating the Effects of White Matter Multiple Sclerosis Lesions on the Volume Estimation of 6 Brain Tissue Segmentation Methods
  • Quiet PROPELLER MRI Techniques Match the Quality of Conventional PROPELLER Brain Imaging Techniques
Show more BRAIN

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire