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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleBRAIN

Lateralizing Ability of Single-voxel Proton MR Spectroscopy in Hippocampal Sclerosis: Comparison with MR Imaging and Positron Emission Tomography

Sun-Won Park, Kee-Hyun Chang, Hong-Dae Kim, In Chan Song, Dong Soo Lee, Sang Kun Lee, Chun-Kee Chung, In Kyu Yu, Moon Hee Han and Yang Hee Park
American Journal of Neuroradiology April 2001, 22 (4) 625-631;
Sun-Won Park
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Kee-Hyun Chang
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Hong-Dae Kim
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In Chan Song
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Dong Soo Lee
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Sang Kun Lee
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Chun-Kee Chung
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In Kyu Yu
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Moon Hee Han
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Yang Hee Park
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    fig 1.

    Concordance among MR imaging, MRS, and PET in right hippocampal sclerosis. Oblique coronal T2-weighted MR image (top row, middle) shows right hippocampal sclerosis (arrow), in concordance with PET scan (bottom row, middle), which shows decreased metabolism in right temporal lobe (arrow). The MR spectrum from the right hippocampus (Rt) shows marked decrease in NAA/Cho ratio (arrow). The MR spectrum from left hippocampus is normal (Lt)

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    fig 2.

    Discordant MRS with MR imaging and PET in left hippocampal sclerosis. Oblique coronal T2-weighted MR image (top row, middle) shows left hippocampal atrophy (arrow), in concordance with PET scan (bottom row, middle), which shows decreased metabolism in left temporal lobe (arrow). However, the MR spectrum from the left hippocampus (Lt) appears within normal range (false-negative finding), based on the abnormal criteria of an NAA/Cho ratio of 0.8 or less or an NAA/Cr ratio of 1.0 or less. The MR spectrum from the left hippocampus (Lt) shows a decrease in NAA/Cho and NAA/Cr ratios (arrow) on right side (Rt) (false-positive finding)

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    fig 3.

    Bilateral abnormality on MRS in left hippocampal sclerosis. Oblique coronal T2-weighted MR image (top row, middle) shows left hippocampal sclerosis with increased signal intensity (arrow), in concordance with PET scan (bottom row, middle), which shows decreased metabolism (arrow) in left temporal lobe. The MR spectra (Rt and Lt) show bilateral abnormalities (arrows), decreased NAA/Cho ratios bilaterally, and decreased NAA/Cr ratio on right side

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    Summary of MRS and PET results in lateralization of hippocampal sclerosis (n = 33)

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American Journal of Neuroradiology
Vol. 22, Issue 4
1 Apr 2001
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Cite this article
Sun-Won Park, Kee-Hyun Chang, Hong-Dae Kim, In Chan Song, Dong Soo Lee, Sang Kun Lee, Chun-Kee Chung, In Kyu Yu, Moon Hee Han, Yang Hee Park
Lateralizing Ability of Single-voxel Proton MR Spectroscopy in Hippocampal Sclerosis: Comparison with MR Imaging and Positron Emission Tomography
American Journal of Neuroradiology Apr 2001, 22 (4) 625-631;

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Lateralizing Ability of Single-voxel Proton MR Spectroscopy in Hippocampal Sclerosis: Comparison with MR Imaging and Positron Emission Tomography
Sun-Won Park, Kee-Hyun Chang, Hong-Dae Kim, In Chan Song, Dong Soo Lee, Sang Kun Lee, Chun-Kee Chung, In Kyu Yu, Moon Hee Han, Yang Hee Park
American Journal of Neuroradiology Apr 2001, 22 (4) 625-631;
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