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Research ArticleBRAIN

Diffusion-weighted MR Imaging in a Case of Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Strokelike Episodes

Kiminobu Yonemura, Yasuhiro Hasegawa, Kazumi Kimura, Kazuo Minematsu and Takenori Yamaguchi
American Journal of Neuroradiology February 2001, 22 (2) 269-272;
Kiminobu Yonemura
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Yasuhiro Hasegawa
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Kazumi Kimura
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Kazuo Minematsu
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Takenori Yamaguchi
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    fig 1.

    A, Axial T2-weighted image obtained at the time of initial hospitalization (8 days after the onset of symptoms).

    B, Contrast-enhanced T1-weighted image reveals small hyperintense lesions with patchy and punctate enhancement in the bilateral occipital cortices.

    C and D, Follow-up images obtained 2 months later show resolution of the lesions.

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    fig 2.

    A, Axial T2-weighted image obtained at the time of the second hospitalization (2 days after the onset of symptoms).

    B, Diffusion-weighted image shows an extensive hyperintense lesion involving the cortex and subcortical white matter in the left occipital lobe.

    C, Corresponding ADC map reveals no obvious abnormalities.

    D, 99mTc-HMPAO SPECT scan obtained on day 3 shows a remarkable increase in tracer accumulation in the left occipital lobe. Follow-up images obtained 2 weeks later (not shown) indicated the resolution of the left occipital abnormality with residual localized atrophy.

  • fig 3.
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    fig 3.

    A, Axial T2-weighted image obtained at the time of the third hospitalization (2 days after the onset of symptoms).

    B, Diffusion-weighted image reveals a cortical hyperintense lesion in the right occipital lobe.

    C, 99mTc-HMPAO SPECT scan obtained on the same day shows a remarkable increase in tracer accumulation in the right occipital cortex. Follow-up MR images obtained 2 weeks later (not shown) revealed resolution of the right occipital abnormality, and SPECT scans obtained 16 days after the onset of symptoms (not shown) showed a normal accumulation in the right occipital cortex.

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American Journal of Neuroradiology
Vol. 22, Issue 2
1 Feb 2001
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Cite this article
Kiminobu Yonemura, Yasuhiro Hasegawa, Kazumi Kimura, Kazuo Minematsu, Takenori Yamaguchi
Diffusion-weighted MR Imaging in a Case of Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Strokelike Episodes
American Journal of Neuroradiology Feb 2001, 22 (2) 269-272;

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Diffusion-weighted MR Imaging in a Case of Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Strokelike Episodes
Kiminobu Yonemura, Yasuhiro Hasegawa, Kazumi Kimura, Kazuo Minematsu, Takenori Yamaguchi
American Journal of Neuroradiology Feb 2001, 22 (2) 269-272;
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Cited By...

  • Apparent Diffusion Coefficients of Metabolites in Patients with MELAS Using Diffusion-Weighted MR Spectroscopy
  • Serial Diffusion Imaging in a Case of Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes
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