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Improved Turnaround Times | Median time to first decision: 12 days

Research ArticleBRAIN

MR Imaging and Localized Proton Spectroscopy of the Precentral Gyrus in Amyotrophic Lateral Sclerosis

Brian C. Bowen, Pradip M. Pattany, Walter G. Bradley, James B. Murdoch, Francisco Rotta, Akmal A. Younis, Robert C. Duncan and Robert M. Quencer
American Journal of Neuroradiology April 2000, 21 (4) 647-658;
Brian C. Bowen
aFrom the Departments of Radiology (B.C.B., P.M.P., R.M.Q.), Neurology (W.G.B., F.R.), Electrical & Computer Engineering (A.A.Y.), and Epidemiology & Public Health (R.C.D.), University of Miami School of Medicine, Miami, FL; and Picker International, MR Imaging Division, Cleveland, OH (J.B.M.).
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Pradip M. Pattany
aFrom the Departments of Radiology (B.C.B., P.M.P., R.M.Q.), Neurology (W.G.B., F.R.), Electrical & Computer Engineering (A.A.Y.), and Epidemiology & Public Health (R.C.D.), University of Miami School of Medicine, Miami, FL; and Picker International, MR Imaging Division, Cleveland, OH (J.B.M.).
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Walter G. Bradley
aFrom the Departments of Radiology (B.C.B., P.M.P., R.M.Q.), Neurology (W.G.B., F.R.), Electrical & Computer Engineering (A.A.Y.), and Epidemiology & Public Health (R.C.D.), University of Miami School of Medicine, Miami, FL; and Picker International, MR Imaging Division, Cleveland, OH (J.B.M.).
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James B. Murdoch
aFrom the Departments of Radiology (B.C.B., P.M.P., R.M.Q.), Neurology (W.G.B., F.R.), Electrical & Computer Engineering (A.A.Y.), and Epidemiology & Public Health (R.C.D.), University of Miami School of Medicine, Miami, FL; and Picker International, MR Imaging Division, Cleveland, OH (J.B.M.).
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Francisco Rotta
aFrom the Departments of Radiology (B.C.B., P.M.P., R.M.Q.), Neurology (W.G.B., F.R.), Electrical & Computer Engineering (A.A.Y.), and Epidemiology & Public Health (R.C.D.), University of Miami School of Medicine, Miami, FL; and Picker International, MR Imaging Division, Cleveland, OH (J.B.M.).
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Akmal A. Younis
aFrom the Departments of Radiology (B.C.B., P.M.P., R.M.Q.), Neurology (W.G.B., F.R.), Electrical & Computer Engineering (A.A.Y.), and Epidemiology & Public Health (R.C.D.), University of Miami School of Medicine, Miami, FL; and Picker International, MR Imaging Division, Cleveland, OH (J.B.M.).
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Robert C. Duncan
aFrom the Departments of Radiology (B.C.B., P.M.P., R.M.Q.), Neurology (W.G.B., F.R.), Electrical & Computer Engineering (A.A.Y.), and Epidemiology & Public Health (R.C.D.), University of Miami School of Medicine, Miami, FL; and Picker International, MR Imaging Division, Cleveland, OH (J.B.M.).
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Robert M. Quencer
aFrom the Departments of Radiology (B.C.B., P.M.P., R.M.Q.), Neurology (W.G.B., F.R.), Electrical & Computer Engineering (A.A.Y.), and Epidemiology & Public Health (R.C.D.), University of Miami School of Medicine, Miami, FL; and Picker International, MR Imaging Division, Cleveland, OH (J.B.M.).
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Article Figures & Data

Figures

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  • fig 1.
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    fig 1.

    Voxel location in a 60-year-old man with definite ALS and clinically severe UMN signs.

    A, Precentral gyrus.

    B, Cuneus gyrus.

  • fig 2.
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    fig 2.

    Proton spectra from same subject and voxel locations as shown in figure 1. The dark line represents the LCModel fit of the spectrum. The assignments of the principal peaks (in ppm) in the in vivo spectrum are as follows: NA = NAA (2.01) + NAAG (2.05), Cr (3.03), Ins (3.56). The complex multiplets of Glu and Gln, whose sum is Glx, are located at approximately 2.1 to 2.5 ppm and 3.7 to 3.8 ppm (see [41]).

    A, Precentral gyrus.

    B, Cuneus gyrus.

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    fig 3.

    Correlation between metabolite concentrations (mmol/L). The formulas for the regression lines are given in the box in the upper left-hand corner. Asterisk indicates multiplication; r, Pearson correlation coefficient for each group.

    A, NA and Cr.

    B, Glu and Cr.

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    fig 4.

    Precentral gyrus metabolite concentrations (mmol/L) as a function of the severity of UMN clinical signs. The length of the line extending above each rectangle indicates the standard error of the mean (SEM).

    A, NA.

    B, Cho.

    C, Glu.

    D, Ins.

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    fig 5.

    Signal intensity changes in the precentral gyri of a 50-year-old woman with definite ALS (clinically moderate UMN signs).

    A–D, Adjacent T2-weighted FSE images (A and B) and corresponding FLAIR images (C and D) show a curvilinear hypointensity (closed arrows) in the region of the motor cortex of the precentral gyrus. In the subcortical white matter of the precentral gyrus, and extending toward the superior frontal gyrus, faint hyperintensity (open arrows) is detected on the FLAIR images but not on the FSE images.

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    TABLE 1:

    Metabolite concentrations (mean ± SEM, mmol/L) from STEAM (TE = 20) spectra

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    TABLE 2:

    Difference in precentral gyrus metabolite concentrations (mean ± SEM, mmol/L) between first and second studies of ALS patients

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    TABLE 3:

    Precentral gyrus signal intensity changes on MR images

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    TABLE 4:

    Change in mean metabolite concentration and MR image signal intensity in the precentral gyrus of ALS patients

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American Journal of Neuroradiology
Vol. 21, Issue 4
1 Apr 2000
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MR Imaging and Localized Proton Spectroscopy of the Precentral Gyrus in Amyotrophic Lateral Sclerosis
Brian C. Bowen, Pradip M. Pattany, Walter G. Bradley, James B. Murdoch, Francisco Rotta, Akmal A. Younis, Robert C. Duncan, Robert M. Quencer
American Journal of Neuroradiology Apr 2000, 21 (4) 647-658;
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  • Advances in molecular pathology, diagnosis, and treatment of amyotrophic lateral sclerosis
  • A Distinct MR Imaging Phenotype in Amyotrophic Lateral Sclerosis: Correlation between T1 Magnetization Transfer Contrast Hyperintensity along the Corticospinal Tract and Diffusion Tensor Imaging Analysis
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Cite this article
Brian C. Bowen, Pradip M. Pattany, Walter G. Bradley, James B. Murdoch, Francisco Rotta, Akmal A. Younis, Robert C. Duncan, Robert M. Quencer
MR Imaging and Localized Proton Spectroscopy of the Precentral Gyrus in Amyotrophic Lateral Sclerosis
American Journal of Neuroradiology Apr 2000, 21 (4) 647-658;

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