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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleBRAIN

Cortical/Subcortical Disease Burden and Cognitive Impairment in Patients with Multiple Sclerosis

Marco Rovaris, Massimo Filippi, Luca Minicucci, Giuseppe Iannucci, Giuseppe Santuccio, Francesca Possa and and Giancarlo Comi
American Journal of Neuroradiology February 2000, 21 (2) 402-408;
Marco Rovaris
aFrom the Neuroimaging Research Unit (M.R., M.F., L.M., G.I.) and the Unit for Clinical Trials (G.S., F.P., G.C.), Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Milan, Italy.
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Massimo Filippi
aFrom the Neuroimaging Research Unit (M.R., M.F., L.M., G.I.) and the Unit for Clinical Trials (G.S., F.P., G.C.), Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Milan, Italy.
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Luca Minicucci
aFrom the Neuroimaging Research Unit (M.R., M.F., L.M., G.I.) and the Unit for Clinical Trials (G.S., F.P., G.C.), Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Milan, Italy.
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Giuseppe Iannucci
aFrom the Neuroimaging Research Unit (M.R., M.F., L.M., G.I.) and the Unit for Clinical Trials (G.S., F.P., G.C.), Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Milan, Italy.
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Giuseppe Santuccio
aFrom the Neuroimaging Research Unit (M.R., M.F., L.M., G.I.) and the Unit for Clinical Trials (G.S., F.P., G.C.), Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Milan, Italy.
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Francesca Possa and
aFrom the Neuroimaging Research Unit (M.R., M.F., L.M., G.I.) and the Unit for Clinical Trials (G.S., F.P., G.C.), Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Milan, Italy.
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Giancarlo Comi
aFrom the Neuroimaging Research Unit (M.R., M.F., L.M., G.I.) and the Unit for Clinical Trials (G.S., F.P., G.C.), Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Milan, Italy.
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    fig 1.

    Axial quantitative MTR image of the brain in a patient with MS, obtained at level of the roof of the lateral ventricles. A and B, The slice is shown before (A) and after (B) manual image segmentation, which precedes any MTR histographic analysis to exclude all extracranial tissues.

    C, The same slice is shown after postprocessing (see Methods); only the cortical/subcortical brain tissue is left to enter the MTR histographic analysis.

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    fig 2.

    MTR histograms of cortical/subcortical brain regions from MS patients without (continuous line) and with (dotted line) cognitive impairment. Vertical lines represent the MTR values at which the integral of the histogram is 25%, 50%, and 75% of the total (ie, MTR25, MTR50 and MTR75). The histogram of MTR values from the cortical/subcortical brain tissue of impaired patients has a lower peak height and location than that obtained from unimpaired patients. For further details and statistical analysis, see text

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    TABLE 1:

    Main demographic and clinical data from MS patients without and with cognitive impairment

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    TABLE 2:

    Total and cortical/subcortical brain MR lesion loads on RARE, fast-FLAIR, and T1-weighted images in MS patients without and with cognitive impairment

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    TABLE 3:

    MT histogram-derived measures of the cortical/subcortical regions in MS patients without and with cognitive impairment

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American Journal of Neuroradiology
Vol. 21, Issue 2
1 Feb 2000
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Cite this article
Marco Rovaris, Massimo Filippi, Luca Minicucci, Giuseppe Iannucci, Giuseppe Santuccio, Francesca Possa and, Giancarlo Comi
Cortical/Subcortical Disease Burden and Cognitive Impairment in Patients with Multiple Sclerosis
American Journal of Neuroradiology Feb 2000, 21 (2) 402-408;

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Cortical/Subcortical Disease Burden and Cognitive Impairment in Patients with Multiple Sclerosis
Marco Rovaris, Massimo Filippi, Luca Minicucci, Giuseppe Iannucci, Giuseppe Santuccio, Francesca Possa and, Giancarlo Comi
American Journal of Neuroradiology Feb 2000, 21 (2) 402-408;
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