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Research ArticleBRAIN

Cortical/Subcortical Disease Burden and Cognitive Impairment in Patients with Multiple Sclerosis

Marco Rovaris, Massimo Filippi, Luca Minicucci, Giuseppe Iannucci, Giuseppe Santuccio, Francesca Possa and and Giancarlo Comi
American Journal of Neuroradiology February 2000, 21 (2) 402-408;
Marco Rovaris
aFrom the Neuroimaging Research Unit (M.R., M.F., L.M., G.I.) and the Unit for Clinical Trials (G.S., F.P., G.C.), Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Milan, Italy.
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Massimo Filippi
aFrom the Neuroimaging Research Unit (M.R., M.F., L.M., G.I.) and the Unit for Clinical Trials (G.S., F.P., G.C.), Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Milan, Italy.
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Luca Minicucci
aFrom the Neuroimaging Research Unit (M.R., M.F., L.M., G.I.) and the Unit for Clinical Trials (G.S., F.P., G.C.), Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Milan, Italy.
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Giuseppe Iannucci
aFrom the Neuroimaging Research Unit (M.R., M.F., L.M., G.I.) and the Unit for Clinical Trials (G.S., F.P., G.C.), Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Milan, Italy.
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Giuseppe Santuccio
aFrom the Neuroimaging Research Unit (M.R., M.F., L.M., G.I.) and the Unit for Clinical Trials (G.S., F.P., G.C.), Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Milan, Italy.
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Francesca Possa and
aFrom the Neuroimaging Research Unit (M.R., M.F., L.M., G.I.) and the Unit for Clinical Trials (G.S., F.P., G.C.), Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Milan, Italy.
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Giancarlo Comi
aFrom the Neuroimaging Research Unit (M.R., M.F., L.M., G.I.) and the Unit for Clinical Trials (G.S., F.P., G.C.), Department of Neuroscience, Scientific Institute Ospedale San Raffaele, Milan, Italy.
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American Journal of Neuroradiology
Vol. 21, Issue 2
1 Feb 2000
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Cite this article
Marco Rovaris, Massimo Filippi, Luca Minicucci, Giuseppe Iannucci, Giuseppe Santuccio, Francesca Possa and, Giancarlo Comi
Cortical/Subcortical Disease Burden and Cognitive Impairment in Patients with Multiple Sclerosis
American Journal of Neuroradiology Feb 2000, 21 (2) 402-408;

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Cortical/Subcortical Disease Burden and Cognitive Impairment in Patients with Multiple Sclerosis
Marco Rovaris, Massimo Filippi, Luca Minicucci, Giuseppe Iannucci, Giuseppe Santuccio, Francesca Possa and, Giancarlo Comi
American Journal of Neuroradiology Feb 2000, 21 (2) 402-408;
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  • Predicting cognition using estimated structural and functional connectivity networks and artificial intelligence in multiple sclerosis
  • T1 Recovery Is Predominantly Found in Black Holes and Is Associated with Clinical Improvement in Patients with Multiple Sclerosis
  • Increased total sodium concentration in gray matter better explains cognition than atrophy in MS
  • Modeling the Relationship among Gray Matter Atrophy, Abnormalities in Connecting White Matter, and Cognitive Performance in Early Multiple Sclerosis
  • Reduced magnetisation transfer ratio in cognitively impaired patients at the very early stage of multiple sclerosis: a prospective, multicenter, cross-sectional study
  • Robust Perfusion Deficits in Cognitively Impaired Patients with Secondary-Progressive Multiple Sclerosis
  • Heterogeneity of cortical lesions in multiple sclerosis: Clinical and pathologic implications
  • Exogenous Leukemia Inhibitory Factor Stimulates Oligodendrocyte Progenitor Cell Proliferation and Enhances Hippocampal Remyelination
  • Postmortem verification of MS cortical lesion detection with 3D DIR
  • Widespread cortical thinning characterizes patients with MS with mild cognitive impairment
  • Cognitive assessment and quantitative magnetic resonance metrics can help to identify benign multiple sclerosis
  • Use of combined conventional and quantitative MRI to quantify pathology related to cognitive impairment in multiple sclerosis
  • Magnetisation transfer ratio in the normal appearing white matter predicts progression of disability over 1 year in early primary progressive multiple sclerosis
  • Clinically isolated syndromes: Predicting and delaying multiple sclerosis
  • White matter integrity and cognition in childhood and old age
  • Cognitive impairment as marker of diffuse brain abnormalities in early relapsing remitting multiple sclerosis
  • Cognitive presentation of multiple sclerosis: evidence for a cortical variant
  • A longitudinal study of brain atrophy and cognitive disturbances in the early phase of relapsing-remitting multiple sclerosis
  • Neuroradiological Imaging and Neuropsychological Testing in Multiple Sclerosis
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This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Predictors of Reperfusion in Patients with Acute Ischemic Stroke
  • Enhanced Axonal Metabolism during Early Natalizumab Treatment in Relapsing-Remitting Multiple Sclerosis
  • Progression of Microstructural Damage in Spinocerebellar Ataxia Type 2: A Longitudinal DTI Study
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