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1335 Arginase-1 vaccine promotes T cell immunity against arginase-1⁺ cells, controls tumor growth via immune modulation of tumor microenvironment
Marco Carretta, Marion Chapellier, Ines Lecoq, Preeyam Patel, Erika Sutanto-Ward, Shih-Chun Shen, Mia Aaboe Jørgensen, Evelina Martinenaite, Alex J Muller, Mads H Andersen, Ayako Pedersen

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1486; DOI: 10.1136/jitc-2023-SITC2023.1335
1336 Cancer vaccine co-targeting PRAME and PD-L1 exerts significant tumor growth inhibition in syngeneic mouse hepatocellular carcinoma models
Kin-Tak Chan, Chen-Yi Chiang, Wing-Yan Ho, Melvin Toh, Hsin-Wei Chen

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1487; DOI: 10.1136/jitc-2023-SITC2023.1336
1337 The preclinical characterization and translational research of ATG-031, a first-in-class humanized anti-CD24 antibody, for the treatment of solid tumors and hematological malignancies
Peng Chen, Jishun Chen, Min Deng, Jiamei Luo, Yun Liu, Rong Guo, Yunkai Zhang, Linjie Tian, Jay Mei, Bo Shan, Bing Hou

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1488-A1491; DOI: 10.1136/jitc-2023-SITC2023.1337
1338 Crystallography-guided characterization of novel cytosolic DNase 3’ repair exonuclease 1 (TREX1) inhibitors
Valerie Chen, David Hsieh, Dave Freund, Anja Holtz, Jesus Garcia Lopez, Alyssa Mullenix, Jamie Cope, Peppi Prasit, Anne Moon, Nathan Standifer, Thomas Dubensky, Henry Johnson, Dara Burdette

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1492; DOI: 10.1136/jitc-2023-SITC2023.1338
1339 Systemically administered onco-selective mRNA LNP achieves tumor regression and improves overall survival, as monotherapy
Rudy Christmas, Jieni Xu, Mark Krimmer, Yulia Rybakova, Nicole Lessard, Tom Addison, Isaak Mueller, Leona Lee, Cafer Ozdemir, Burak Yilmaz, Yusuf Erkul, Manfred Kraus, Aniela Jakubowski

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1493; DOI: 10.1136/jitc-2023-SITC2023.1339
1340 NDI-101150 is a potent and highly selective hematopoietic progenitor kinase 1 (HPK1) inhibitor that promotes a robust and broad anti-tumor immune response
David Ciccone, Fu-Shan Kuo, Scott Boiko, Scott Daigle, Samantha Carreiro, Neelu Kaila, Gene Yau, Esha A Gangolli, Denise Levasseur, Bhaskar Srivastava, Frank G Basile, Christine Loh

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1494; DOI: 10.1136/jitc-2023-SITC2023.1340
1341 Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) neutralization counteracts T cell immune evasion in breast cancer
Giorgia Colombo, Cristina Travelli, Mario Paolo Colombo, Sabina Sangaletti, Armando Genazzani

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1495; DOI: 10.1136/jitc-2023-SITC2023.1341
1342 A novel dual CAB Nectin-4 x CD3 bispecific antibody targeting solid tumors
Ana Paula G Cugnetti, Mathew Lucas, Haizhen Liu, Charles Xing, Jing Wang, Patty McNeely, Solimarie Joyner, Kyrie Johnson, Kathryn Woodard, Wei Zhou, Cathy Chang, Gerhard Frey, William J Boyle, Jay M Short

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1496; DOI: 10.1136/jitc-2023-SITC2023.1342
1343 Novel conditionally active bispecific HER2 x CD3 T cell engager targeting solid tumors
Ana Paula G Cugnetti, Haizhen Liu, Patricia McNeeley, Mathew Lucas, Charles Xing, Solimarie Joyner, Kyrie Johnson, Kathryn Woodard, Wei Zhou, Cathy Chang, Gerhard Frey, William J Boyle, Jay M Short

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1497; DOI: 10.1136/jitc-2023-SITC2023.1343
1344 N17350 combines selective cancer killing with adaptive immune activation to eradicate tumors
Chang Cui, Ravindra Gujar, Christine Lee, Nicole Grigaitis, Maria Fumagalli, Nicole Martinez, Arezoo Arjmand, Catherine Reardon, Kelly Schoenfelt, Sonia Feau, Lev Becker

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1498; DOI: 10.1136/jitc-2023-SITC2023.1344

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