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1355 DM919, an IND-ready MICA/B-specific antibody, reinforces NKG2D-MICA/B axis and promotes anti-tumor activities
Guangan Hu, Quanju Zhao, Xiaochun Chen, Xiaodong Jiang, Yi Xu, Hong Chang, Sheng Yin, Nan Bing, Dong Zhang

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1509; DOI: 10.1136/jitc-2023-SITC2023.1355
1356 DM926, a novel anti-LILRB1/LILRB2 dual antagonist antibody, promotes adaptive and innate immune response to enhance anti-tumor activity in preclinical models
Guangan Hu, Quanju Zhao, Xiaochun Chen, Xiaodong Jiang, Yi Xu, Hong Chang, Sheng Yin, Nan Bing, Dong Zhang

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1510; DOI: 10.1136/jitc-2023-SITC2023.1356
1357 CD27 is a new promising T cell co-stimulatory target for the cancer immunotherapy – development and selection of a lead anti-CD27 agonist antibody
Shawn Iadonato, Yulia Ovechkina, Kurt Lustig, Thierry Guillaudeux

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1511; DOI: 10.1136/jitc-2023-SITC2023.1357
1358 Tissue-targeted lipid nanoparticle delivery for mRNA encoding bispecific T-cell engager demonstrated potent antitumor effects on both hematological malignancies and solid tumors
Xin Kai, Yixin Zhang, Benjamin Wei, Daniella Tatang, Stu Angus, Caining Jin, Kun Huang, Changfeng Huang, Haishan Li, Qi Jiang, Qiaobing Xu, Kate Zhang

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1512-A1513; DOI: 10.1136/jitc-2023-SITC2023.1358
1359 NTX-0471, engineered multivalent SIRPa and bispecific SIRPa-antiCCR4 molecules demonstrate superior activity providing path for mRNA expressed in-vivo biologics
Gunasekaran Kannan, Adrienne Sallets, Gowrisudha Adusumilli, Srinivasa Bandi, Shruti Lal, Ray Low, Weiqun Liu, Ole Audun Haabeth, Colin McKinlay, Pei-Ken Hsu, Kimmy Ferry, Anustha Sharma, Jenna Triplett, Meredith Leong, Evan McCartney-Melstad, Samuel Deutsch

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1514-A1515; DOI: 10.1136/jitc-2023-SITC2023.1359
1360 Treatment with a novel hexavalent OX40 agonist remodels the tumor microenvironment to favor anti-tumor immunity in mice
Melissa Kasiewicz, Annah Rolig, Rashi Yadav, Yaiza Diaz De Durana, William L Redmond

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1516; DOI: 10.1136/jitc-2023-SITC2023.1360
1361 Neoadjuvant CD40 agonism remodels the tumor immune microenvironment in locally advanced esophageal/gastroesophageal junction cancer
Bridget P Keenan, Maira Soto, Erin L Filbert, Hai Yang, Stephanie Starzinski, Alec Starzinski, Marissa Gin, Brandon Chen, Phi Le, Tony Li, Brandon Bol, Alexander Cheung, Li Zhang, Frank J Hsu, Andrew H Ko, Lawrence Fong

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1517; DOI: 10.1136/jitc-2023-SITC2023.1361
1362 Agonistic 4–1BB IgM antibodies enhance CD8+ T cell proliferation and proinflammatory cytokine secretion in vitro and in vivo
Tasnim Kothambawala, Thin Wai, Poonam Yakkundi, Natalia L dos Santos, Adam Smith, Gary Bolton, Aditya Bharti, Balaji Banoth, Deepal Pandya, Vidhya Bai Krishnoji Rao, Elizabeth Perez, Sachi Rahman, Paul Hinton, Yuan Cao, Harrison Horwitz, Dean Ng, Umesh Muchhal, Bruce A Keyt, Angus M Sinclair, Hyewon Phee, Beatrice Wang

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1518; DOI: 10.1136/jitc-2023-SITC2023.1362
1363 Multilamellar mRNA lipid particle aggregate vaccines safely reprogram the tumor microenvironment and induce objective radiographic response in canines
John A Ligon, Brian Stover, Frances Weidert, Adam Grippin, Lana Fagman, Jonathan Chardon-Robles, Gabriel Jobin, Chao Xie, Duy Nguyen, Nicholas Diodati, W Gregory Sawyer, Paul Castillo, Natalie Silver, Joanne Lagmay, Leighton Elliott, Eugene Hwang, Michael Isakoff, Lars Wagner, Rowan Milner, Duane A Mitchell, Hector Mendez-Gomez, Study Staff, Elias Sayour

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1519; DOI: 10.1136/jitc-2023-SITC2023.1363
1364 Discovery of NXA01, a novel CD24 antibody with tumor selectivity and potent anti-tumor activity
Junli Liu, Puwei Yuan, Ying Lei, Guanghua Lv, Yang Xie, Fan Liu, Taylor B Guo

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1520; DOI: 10.1136/jitc-2023-SITC2023.1364

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