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1488 Melanoma cell-of-origin PDL1 promotes early tumor progression and distinct immune outcomes in a novel autochthonous NRAS-mutant melanoma model
Carlos Ontiveros, Clare Murray, Haiyan Bai, Mary Jo Turk, Tyler Curiel

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1652; DOI: 10.1136/jitc-2023-SITC2023.1488
1489 Multispectral imaging to detect immune phenotypes in pre and post therapy breast cancer patient specimens
Bhavika Patel, Stephanie Allen, Brenna Dennison, Jacob Stapleton, Roni Archuleta, Mary Lou Rath, Sameer Talwalkar

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1653; DOI: 10.1136/jitc-2023-SITC2023.1489
1490 High-plex co-detection of RNA and protein to explore tumor-immune interactions utilizing RNAscope with imaging mass cytometry
James Pemberton, Smriti Kala, Anushka Dikshit, Clinton Hupple

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1654; DOI: 10.1136/jitc-2023-SITC2023.1490
1491 Aberrant EGFR activation drives enhanced infiltration of immunosuppressive microglia and macrophages in the glioblastoma tumor immune microenvironment
Marissa S Pioso, Katie B Grausam, Marissa Li, Joshua J Breunig, David A Nathanson, Robert M Prins

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1655; DOI: 10.1136/jitc-2023-SITC2023.1491
1492 Clonal hematopoiesis of indeterminate potential alters solid tumor microenvironment and outcomes in triple negative breast cancer
Sarah C Reed, Chad Potts, P Brent Ferrell, Ben Ho Park

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1656; DOI: 10.1136/jitc-2023-SITC2023.1492
1493 Developing a 3D multicellular model to investigate stromal and immune interactions in colorectal cancer tumour microenvironment
Eileen Reidy, Niamh Leonard, Abhay Pandit, Aideen E Ryan

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1657; DOI: 10.1136/jitc-2023-SITC2023.1493
1494 Role of gain of function p53 mutations in macrophage polarization and myeloid-derived suppressor cells in head and neck squamous cell carcinoma
Alanis Rodriguez Rosario, Fabio Henrique Brasil Da Costa, Nicholas Balbin, Roberto Rangel, Abdullah A Osman, Jeffrey N Myers, Andrew Sikora, Roberto Rangel

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1658; DOI: 10.1136/jitc-2023-SITC2023.1494
1495 Non-small cell lung cancer cells shape their tumor microenvironment towards a distinct inflammatory profile in vitro based on their molecular and phenotypic characteristics
Julia Schueler, Nathalie Harrer, Herwig Machat, Wolfgang Sommergruber

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1659; DOI: 10.1136/jitc-2023-SITC2023.1495
1496 Deciphering the influence of different cell types shaping the tumor microenvironment of lung cancer in an invitro multicellular assay
Julia Schueler, Anne Loehr, Lea Groene, Anna Edinger, Nathalie Harrer, Wolfgang Sommergruber

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1660; DOI: 10.1136/jitc-2023-SITC2023.1496
1497 The epithelium-stroma interface serves as a barrier to immune cell infiltration across tumor immune phenotypes in epithelial cancers
Xinwei Sher, Fredrick D Gootkind, Antoine Italiano, Florent Peyraud, Jean-Philippe Guégan, Guy T Clifton, Laura A Dillon

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1661; DOI: 10.1136/jitc-2023-SITC2023.1497

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