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1376 Regulation of non-canonical proteins encoded by small open reading frames via nonsense-mediated decay pathway
Parthiban Periasamy, Craig Joseph, Harsha Gowda, Joe Yeong

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1531; DOI: 10.1136/jitc-2023-SITC2023.1376
1377 Messenger RNA nanoparticles targeting fusion-driven malignancies
Sadeem Qdaisat, Leighton Elliott, Dingpeng Zhang, Hector Mendez-Gomez, Study Staff, Elias Sayour

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1532; DOI: 10.1136/jitc-2023-SITC2023.1377
1378 Discovery and characterization of PM-4321, a selective inhibitor of the aryl hydrocarbon receptor (AHR) with anti-tumor immunomodulatory effects
Kritika Ramani, Christopher Wrocklage, Ming Bai, Anna Nicole Bosco, Benjamin Carter, Iulian Pruteanu-Malinici, Lizeth Perales, Wojciech Dworakowski, Brenda K Eustace, Kun Don Yi, Charles Sinclair, Seema Kumar, Matthew Abbinanti, Alessandra Bartolozzi, John Robert Proudfoot, Timothy Briggs, John Steven Taylor, Luisa Salter-Cid, Sheila Ranganath

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1533; DOI: 10.1136/jitc-2023-SITC2023.1378
1379 Novel backbone-modified analogues of antigenic peptides improve immunogenic capabilities of anti-tumor peptide vaccines
Ichwaku Rastogi, Ruslan Gibadullin, Samuel H Gellman, Douglas McNeel

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1534; DOI: 10.1136/jitc-2023-SITC2023.1379
1380 Non-clinical results and design of first-in-human study for GIGA-564, a third-generation anti-CTLA-4 monoclonal antibody
Jason M Redman, Vincent Poon, Ariel Niedecken, Yao Chiang, Rong Deng, Kacy Stadtmiller, Michael A Asensio, Janice Lansita, Kyle P Carter, Ellen K Wagner, Edward Garmey, Carl Millward, James L Gulley, Erica L Stone

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1535; DOI: 10.1136/jitc-2023-SITC2023.1380
1381 Discovery of ALG-093989, a highly potent and orally bioavailable small molecule PD-L1 inhibitor for the treatment of cancers
Heleen Roose, Kristina Rekstyte-Matiene, Sarah Stevens, Kusum Gupta, Sandra Chang, Cheng Liu, Vladimir Serebryany, Lillian Adame, Kha Le, Antitsa Stoycheva, Lawrence M Blatt, Leonid Beigelman, Sushmita Chanda, David B Smith, Julian A Symons, Andreas Jekle, Tongfei Wu

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1536; DOI: 10.1136/jitc-2023-SITC2023.1381
1382 Discovery of ALG-094103, a liver-targeted and orally bioavailable small molecule PD-L1 inhibitor for the treatment of liver cancer
Heleen Roose, Kristina Rekstyte-Matiene, Sarah Stevens, Kusum Gupta, Sandra Chang, Cheng Liu, Vladimir Serebryany, Lillian Adame, Kha Le, Antitsa Stoycheva, Lawrence M Blatt, Leonid Beigelman, Sushmita Chanda, David B Smith, Julian A Symons, Andreas Jekle, Tongfei Wu

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1537; DOI: 10.1136/jitc-2023-SITC2023.1382
1383 Preclinical characterization of D3L-002, a novel cancer immunotherapy bispecific antibody that elicits potent anti-tumor efficacy via co-blocking TIGIT and PVRIG
Haopeng Rui, Baotian Yang, Xiaofeng Yang, Zhiqiang Zheng, Zhiqiang Chen, Jingtao Lu, Peggy Wu, Jia Wang, Janet Chen, Allison Wang, George Chen

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1538; DOI: 10.1136/jitc-2023-SITC2023.1383
1384 LNK101, a highly differentiated T-cell engager (TCE) targeting CD3 and mesothelin (MSLN) in solid tumors
Linda Santiago, Ashok Bandaranayake, Colin Correnti, Ida Lin, Man Kid Chan, Scott Delbecq, Midori Clarke, Jane Carter, Eric Gruff, William Bracken, David Meininger, Diana Hausman, Christopher Mehlin

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1539; DOI: 10.1136/jitc-2023-SITC2023.1384
1385 Dual Inhibition of DGKα and DGKζ increases T cell and NK cell activity
Patrick G Schweickert, Gabrielle L Reiner, Casey G Mitchell, Dana Piovesan, Cesar Meleza, Juan Jose Fung, Ning Wang, Sean Cho, Jeremy Fournier, Matthew J Walters, Kelsey E Sivick Gauthier

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (Suppl 1) A1540; DOI: 10.1136/jitc-2023-SITC2023.1385

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