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402 DRAGON: Phase 1 trial of SRK-181, a latent TGFβ1 inhibitor in combination with anti-PD-(L)1 inhibitors for patients with solid tumors unresponsive to anti-PD-(L)1 therapy alone
Lu Gan, Johanna Bendell

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A244-A245; DOI: 10.1136/jitc-2020-SITC2020.0402
423 Safety and preliminary efficacy of intratumoral cavrotolimod (AST-008), a spherical nucleic acid TLR9 agonist, in combination with pembrolizumab in patients with advanced solid tumors
Steven O’Day, Cesar Perez, Trisha Wise-Draper, Glenn Hanna, Shailender Bhatia, Ciara Kelly, Theresa Medina, Douglas Laux, Adil Daud, Sunandana Chandra, Montaser Shaheen, Ling Gao, Melissa Burgess, Leonel Hernandez-Aya, Cecilia Yeung, Kimberly Smythe, Emil DeGoma, Weston Daniel, Douglas Feltner, Laurel Sindelar, Robert Michel, Alice Bexon, Martin Bexon, Mohammed Milhem

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A257-A258; DOI: 10.1136/jitc-2020-SITC2020.0423
425 Investigation of Wnt ligand signaling regulators as a predictor of Anti-PD-1 response in metastatic melanoma
Nicholas DeVito, Michael Sturdivant, Luke Wachsmuth, John Strickler, Georgia Beasley, Rami Al-Rohil, April Salama, Brent Hanks

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A258-A259; DOI: 10.1136/jitc-2020-SITC2020.0425
432 3-year results of the phase 2 randomized trial for talimogene laherparepvec (T-VEC) neoadjuvant treatment plus surgery vs surgery in patients with resectable stage IIIB-IVM1a melanoma
Reinhard Dummer, David Gyorki, John Hyngstrom, Adam Berger, Robert Conry, Lev Demidov, Edward Chan, Hoi-Shen Radcliffe, Mark Faries, Merrick Ross

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A263; DOI: 10.1136/jitc-2020-SITC2020.0432
436 Rational sequencing of immune-oncology therapies achieves durable response and immunologic memory
Robert Saddawi-Konefka, Aoife O’Farrell, Andrew Sharabi, Joseph Califano, J Silvio Gutkind, Robert Saddawi-Konefka

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A265-A266; DOI: 10.1136/jitc-2020-SITC2020.0436
439 Dual modes of action for anti-TIM-3 antibody MBG453 in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML): preclinical evidence for immune-mediated and anti-leukemic activity
Catherine Sabatos-Peyton, Tyler Longmire, Lisa Baker, Nidhi Patel, Anne-Sophie Wavreille, Melanie Verneret, Pushpa Jayaraman, Xiaomo Jiang, Stephanie Schwartz, Viviana Cremasco, Hongbo Lu, Shumei Qiu, Fiona Sharp, Mikael Rinne, Glenn Dranoff

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A267; DOI: 10.1136/jitc-2020-SITC2020.0439
440 Activity and safety of camrelizumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced non-small-cell lung cancer
Guo Gui Sun, Jing Hao Jia, Peng Gao, Xue Min Yao, Ming Da Chen, Wei Nan Yao, Lu Sun, Wei Wang

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A267-A268; DOI: 10.1136/jitc-2020-SITC2020.0440
441 Outcomes of patients with metastatic renal cell carcinoma with intermediate- or poor-risk symptomatic disease who received their first cycle of nivolumab and ipilimumab while being hospitalized
Omar Alhalabi, Elshad Hasanov, John Araujo, Jianbo Wang, Matthew Campbell, Sangeeta Goswami, Amishi Shah, Jianjun Gao, Pavlos Msaouel, Nizar Tannir

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A268; DOI: 10.1136/jitc-2020-SITC2020.0441
443 An immunotherapy trio in advanced HNSCC for coordinated B and T cell antigen response
Bernard Fox, Tarsem Moudgil, Traci Hilton, Noriko Iwamoto, Christopher Paustian, Adi Mehta, Fridtjof Lund-Johansen, Rachel Sanborn, Bryan Bell, Madeleine Laws, Glenna McDonnell, Yoshinobu Koguchi, Carlo Bifulco, Brian Piening, Carmen Ballesteros Merino, Shawn Jensen, Takashi Shimada, Hong-Ming Hu, Walter Urba, Rom Leidner, Marcus Couey, Marcus Couey

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A269-A270; DOI: 10.1136/jitc-2020-SITC2020.0443
447 VISTA targeting remodels the tumor microenvironment to overcome adaptive resistance
Janet Lines, Evelien Schaafsma, Walburga Croteau, Mohamed ElTanbouly, Elizabeth Nowak, Nicole Smits, Cecilia Webber, Dina Rabadi, Jie Deng, Chao Cheng, Randolph Noelle

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A271-A272; DOI: 10.1136/jitc-2020-SITC2020.0447

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