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448 Discovery of clinical candidate IK-175, a selective orally active AHR antagonist
Karen Mcgovern, Alfredo Castro, Jill Cavanaugh, Marta Sanchez-Martin, Jeremy Tchaicha, Sakeena Syed, Hyejin Frosch, Prabitha Natarajan, Katie O’Callaghan, Ben Amidon, X Michelle Zhang, Jeff Ecsedy

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A272; DOI: 10.1136/jitc-2020-SITC2020.0448
452 Combination treatment using KISIMA^TM protein-based cancer vaccine and systemic STING agonist results in profound modulation of tumor microenvironment and improved tumor control
Matteo Rossi, Elodie Belnoue, Susanna Carboni, Wilma Besson-Di Berardino, Erika Riva, Marie-Laure Santiago-Raber, Madiha Derouazi

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A274-A275; DOI: 10.1136/jitc-2020-SITC2020.0452
453 Novel combination immunotherapy for boosting and priming immune responses in pancreatic cancer: strong anti-tumour effects with interleukin-15 and CD40 agonist treatment
Jonas Van Audenaerde, Elly Marcq, Bianca von Scheidt, Ashleigh Davey, Amanda Oliver, Jorrit De Waele, Delphine Quatannens, Jinthe Van Loenhout, Patrick Pauwels, Geert Roeyen, Filip Lardon, Clare Slaney, Marc Peeters, Michael Kershaw, Phillip Darcy, Evelien Smits

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A275-A276; DOI: 10.1136/jitc-2020-SITC2020.0453
465 Radiotherapy and CTLA-4 blockade expand anti-tumor T cells differentiation states and cooperate with CD40 agonist to induce tumor rejection
Nils Rudqvist, Claire Lhuillier, Maud Charpentier, Erik Wennerberg, Sheila Spada, Caroline Sheridan, Xi Kathy Zhou, Tuo Zhang, Jennifer Sims, Alicia Alonso, Sandra Demaria

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A283-A284; DOI: 10.1136/jitc-2020-SITC2020.0465
468 Enhancers and repressors of immunotherapy: translational perspectives on gene-mediated cytotoxic immunotherapy in glioblastoma
Sean Lawler, Marilin Koch, Mikolay Zdioruk, Estuardo Aguilar-Cordova, Laura Aguilar, Brian Guzik, Ghazaleh Tabatabai, Michal Nowicki, E Antonio Chiocca

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A286; DOI: 10.1136/jitc-2020-SITC2020.0468
470 Targeting Pan-Tumor Associated Antigen B7H3 via Combination of Tri-specific Killer Engager and Off-the-shelf NK Cell Therapy Enhances Specificity and Function Against a Broad Range of Solid Tumors
Jeffrey Miller, Nicholas Zorko, Behiye Kodal, Zachary Davis, Alexander Lenvik, Todd Lenvik, Joshua Walker, Daniel Vallera, Svetlana Gaidarova, Alejandro Garcia, Tom Lee, Ryan Bjordahl, Bahram Valamehr, Frank Cichocki, Martin Felices

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A287-A288; DOI: 10.1136/jitc-2020-SITC2020.0470
472 ImmunoPET-informed sequence for focused ultrasound-targeted mCD47 blockade controls glioma
Natasha Sheybani, Soumen Paul, Katelyenn McCauley, Victoria Breza, Stuart Berr, G Wilson Miller, Kiel Neumann, Richard Price

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A288-A289; DOI: 10.1136/jitc-2020-SITC2020.0472
475 Incidental finding of colorectal cancer in a COVID-19 patient, followed by deep profiling of SARS-CoV-2-associated immune landscape and tumour microenvironment
Chun Chau Lawrence Cheung, Xinru Lim, Denise Goh, Tracy Zhijun Tien, Jeffrey Chun Tatt Lim, Thuan Tong Tan, Shirin Kalimuddin, Jia Lin Ng, Jenny Guek-Hong Low, Joe Yeong, Kiat Hon Lim

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A291-A292; DOI: 10.1136/jitc-2020-SITC2020.0475
478 Translation of a therapeutic neoantigen vaccine workflow to SARS-CoV-2 vaccine development
Christof Smith, Sarah Entwistle, Caryn Willis, Steven Vensko, Wolfgang Beck, Jason Garness, Maria Sambade, Eric Routh, Kelly Olsen, Brandon Carpenter, Kaylee Gentry, Maria Fadri, Misha Fini, Amber Washington, Julia Kodysh, Timothy O’Donnell, Carsten Haber, Kirsten Heiss, Volker Stadler, Erik Garrison, Oliver Grant, Robert Woods, Mark Heise, Benjamin Vincent, Alexander Rubinsteyn

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A293-A295; DOI: 10.1136/jitc-2020-SITC2020.0478
477 Deep learning to drive COVID-19 rapid drug repurposing
Sarah Kolitz, Jason Kim, Jenny Zhang, Yoonjeong Cha, Sailaja Battula, Rebecca Kusko, Rajaraman Krishnan, Benjamin Zeskind, Howard Kaufman

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A293; DOI: 10.1136/jitc-2020-SITC2020.0477

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