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679 High fiber diet modifies gut microbiome, propionate production, intratumor immune response and is associated with outcome in patients with lung cancer treated with immune checkpoint inhibitors
Corentin Richard, Myriam Benlaifaoui, Omar El Ouarzadi, Khoudia Diop, Antoine Desilets, Julie Malo, Wiam Belkaid, Andréanne Leblanc, Julien Lamontagne, Meriem Messaoudene, Arielle Elkrief, Bertrand Routy

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A408; DOI: 10.1136/jitc-2020-SITC2020.0679
703 Engineered exosomes with altered cellular tropism achieve targeted STING agonist delivery and single-agent tumor control in vivo
Monique Kauke, Nikki Ross, Dalia Burzyn, Shelly Martin, Ke Xu, Nuruddeen Lewis, Charan Leng, Su Chul Jang, Christine McCoy, Stephanie Yu, Kevin Dooley, Sriram Sathyanarayanan, Jonathan Finn

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A422-A423; DOI: 10.1136/jitc-2020-SITC2020.0703
706 BT7480, a fully synthetic tumor-targeted immune cell agonist (TICA™) induces tumor localized CD137 agonism and modulation of tumor immune microenvironment
Punit Upadhyaya, Kristen Hurov, Jessica Kublin, Jun Ma, Elizabeth Repash, Marianna Kleyman, Julia Kristensson, Drasti Kanakia, Fanglei You, Liuhong Chen, Eric Haines, Sailaja Battula, Kevin McDonnell, Philip Brandish, Johanna lahdenranta, Nicholas Keen

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A424; DOI: 10.1136/jitc-2020-SITC2020.0706
708 Application of a novel mSENS drug delivery technology for mRNA therapeutics
Sojin Lee, Joon Young Park, Goo-Young Kim, Sang Woo Jo, Minhyuk Yun, Hye Yeong Nam, Helen Cho

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A425; DOI: 10.1136/jitc-2020-SITC2020.0708
712 SBT6290, a systemically administered Nectin-4-directed TLR8 ImmunoTAC (TM) therapeutic, is a potent human myeloid cell agonist for the treatment of Nectin-4-expressing tumors
Heather Metz, Ty Brender, Brenda Stevens, Damion Winship, Jamie Brevik, Michael Comeau, Monica Childs, Jenny Chang, Li-Qun Fan, Hengyu Xu, Jonathan Grey, Jeffrey Adamo, Ben Setter, Ray Carrillo, Sean Smith, Phil Tan, Robert DuBose, Yvette Latchman, Peter Baum, Valerie Odegard

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A427; DOI: 10.1136/jitc-2020-SITC2020.0712
714 PD1 x TGFβR2 bispecifics selectively block TGFβR2 on PD1-positive T cells, promote T cell activation, and elicit an anti-tumor response in solid tumors
Gregory Moore, Suzanne Schubbert, Christine Bonzon, Kendra Avery, Rumana Rashid, Erik Pong, Lukasz Ochyl, Alex Nisthal, Seung Chu, James Ernst, John Desjarlais

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A428; DOI: 10.1136/jitc-2020-SITC2020.0714
715 FS118, a tetravalent bispecific antibody targeting LAG-3 and PD-L1, induces LAG-3 shedding resulting in receptor downregulation by T cells via a novel mechanism of action
Michelle Morrow, Mustapha Faroudi, Krishnendu Chakraborty, Wenjia Liao, Julia Winnewisser, Claire Seal, Daniel Gliddon, Neil Brewis

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A428-A429; DOI: 10.1136/jitc-2020-SITC2020.0715
719 CD122-directed interleukin-2 complexes and αPD-L1 differentially require innate and adaptive immunity to treat local and metastatic bladder cancer
Ryan Reyes, Yilun Deng, Deyi Zhang, Niannian Ji, Neelam Mukherjee, Karen Wheeler, Harshita Gupta, Aravind Kancharla, Myrna Garcia, Anand Kornepati, Robert Svatek, Tyler Curiel

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A430-A431; DOI: 10.1136/jitc-2020-SITC2020.0719
722 Inhibition of integrin avß8-Mediated TGF-ß activation with C6D4 provides improved potency and selectivity vs general TGF-ß inhibitors for cancer immunotherapy
Robert Seed, Stephen Nishimura

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A432-A433; DOI: 10.1136/jitc-2020-SITC2020.0722
723 Lymph node-targeted AMP-vaccine enables tumor-directed mKRAS-specific immune responses with potent polyfunctional and cytolytic activity
Martin Steinbuck, Peter DeMuth, Lochana Seenappa

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A433; DOI: 10.1136/jitc-2020-SITC2020.0723

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