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153 NEO-PTC-01 (BNT-221), an autologous neoantigen-specific T-cell product for adoptive cell therapy of metastatic melanoma
Divya Lenkala, Jessica Kohler, Brian McCarthy, Michael Nelson, Jonathan McGee, Daniel Kallin, Janani Sridar, Paul Turcott, Dewi Harjanto, Cynthia Nijenhuis, Joost Van Den Berg, Richard Gaynor, Marit Van Buuren

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A92-A93; DOI: 10.1136/jitc-2020-SITC2020.0153
154 Marrow-infiltrating lymphocytes (MILs): A novel adoptive immunotherapy for hematological and solid tumors
Eric Lutz, Lakshmi Rudraraju, Elizabeth DeOliveira, Amanda Seiz, Monil Shah, Celine Colmenares, Beverly Dan Fu, Daniela Bota, Collin Brummel, Chad Brenner, Paul Swiecicki, Nicole Fredrich, David Page, Eleni Efstatihiou, Ivan Borrello, Kimberly Noonan

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A93; DOI: 10.1136/jitc-2020-SITC2020.0154
156 Discovery of TSC-100: A natural HA-1-specific TCR to treat leukemia following hematopoietic stem cell transplant therapy
Ribhu Nayar, Sonal Jangalwe, Mollie Jurewicz, Antoine Boudot, Andrew Basinski, Robert Prenovitz, Elizabeth Olesin, Daniel Pollacksmith, Qikai Xu, Yifan Wang, Amy Virbasius, Jeffery Li, Holly Whitton, Garrett Dunlap, Alexander Cristofaro, Nancy Nabilsi, Ruan Zhang, Candace Perullo, Sida Liao, Kenneth Jahan, Kenneth Olivier, Gavin MacBeath, Gavin MacBeath

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A94-A95; DOI: 10.1136/jitc-2020-SITC2020.0156
158 Inhibition of PI3Kδ improves tumor specific T cell immunity and metabolic fitness
Guillermo Rangel Rivera, Guillermo Rangel RIvera, Connor Dwyer, Dimitrios Arhontoulis, Hannah Knochelmann, Aubrey Smith, Megan Wyatt, Amalia Rivera Reyes, Chrystal Paulos

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A95-A96; DOI: 10.1136/jitc-2020-SITC2020.0158
157 A critical role of CD40 and CD70 signaling in cDC1s in expansion and antitumor efficacy of adoptively transferred tumor-specific T cells
Takaaki Oba, Toshifumi Hoki, Takayoshi Yamauchi, Tibor Keler, Henry Marsh, Xuefang Cao, Fumito Ito

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A95; DOI: 10.1136/jitc-2020-SITC2020.0157
160 TLR9-activated B cells imprint adoptively transferred CD8+ T cells with potent tumor immunity and persistence in vivo
Aubrey Smith, Hannah Knochelmann, Megan Wyatt, Connor Dwyer, Guillermo Rangel Rivera, Amalia Rivera Reyes, Jessica Thaxton, Eric Bartee, Mark Rubinstein, Bei Liu, Chrystal Paulos

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A96-A97; DOI: 10.1136/jitc-2020-SITC2020.0160
159 Adoptively transferred CD8+ T cells that target neoantigen persist and regress melanomas to a greater extent than those that target self/tumor-antigen
Amalia Rivera Reyes, Megan Wyatt, Connor Dwyer, Hannah Knochelmann, Aubrey Smith, Guillermo Rangel Rivera, Chrystal Paulos

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A96; DOI: 10.1136/jitc-2020-SITC2020.0159
163 Nice: neoantigen-cytokine-chemokine multifunctional engager for NK cell immunotherapy of solid tumors
Xue Yao, Sandro Matosevic

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A97-A98; DOI: 10.1136/jitc-2020-SITC2020.0163
161 Development of a CD8 co-receptor independent T cell receptor specific for tumor-associated antigen MAGE-A4 for next generation T cell-based immunotherapy
Kathrin Davari, Tristan Holland, Laura Prassmayer, Giulia Longinotti, Kenneth Ganley, Lisa Pechilis, Iulia Diaconu, Prashant Nambiar, Mike Magee, Dolores Schendel, Daniel Sommermeyer, Christian Ellinger, Rer Nat

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A97; DOI: 10.1136/jitc-2020-SITC2020.0161
165 Activating antigen carriers generated with microfluidics cell squeezing drive effective anti-tumor responses
Katarina Blagovic, Amritha Ramakrishnan, Armon Sharei, Howard Bernstein, Katherine Seidl, Defne Yarar

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A98-A99; DOI: 10.1136/jitc-2020-SITC2020.0165

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