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110 In-depth characterization of variability in apheresis collections from normal donor populations for allogeneic cell therapy
Shawn Fahl, Shawn Fahl, Shawn Fahl

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A68-A69; DOI: 10.1136/jitc-2020-SITC2020.0110
109 Dominant-negative TGFβ receptor 2 enhances GPC3-targeting CAR-T cell efficacy against hepatocellular carcinoma
Nina Chu, Michael Overstreet, Ryan Gilbreth, Lori Clarke, Christina Gesse, Eric Tu, Letizia Giardino, Gordon Moody

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A68; DOI: 10.1136/jitc-2020-SITC2020.0109
111 Highly efficient multiplexed base editing enables development of universal CD7-targeting CAR-T Cells to treat T-ALL
Jason Gehrke, Aaron Edwards, Ryan Murray, Angelica Messana, Lindsey Coholan, Henry Poulin, Melissa Le, Alden Ladd, Mark Naniong, Faith Musenge, Adam Camblin, Yeh-Chuin Poh, Sarah Smith, Giuseppe Ciaramella

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A69; DOI: 10.1136/jitc-2020-SITC2020.0111
112 Rational design of chimeric antigen receptor T cells against glypican 3 decouples toxicity from therapeutic efficacy
Letizia Giardino, Ryan Gilbreth, Cui Chen, Erin Sult, Noel Monks, Ravinder Tammali, Jon Chesebrough, Kevin Schifferli, Nina Chu, Jessica Tong, Lori Clarke, Christina Gesse, Xiao-Tao Yao, Karma DaCosta, Kapil Vashisht, Gordon Moody

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A69-A70; DOI: 10.1136/jitc-2020-SITC2020.0112
12 Development of an in vitro assay to assess bispecific T cell engager using T cells from CD3e humanized mice
Jun Zhou, Shuang Zhu, Hongjuan Zhang, Lei Zheng, Mingfa Zang, Annie Xiaoyu An, Shuzong Wang, Davy Xuesong Ouyang, Henry Li, Yujun Huang

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A7; DOI: 10.1136/jitc-2020-SITC2020.0012
114 Preclinical development of a novel iPSC-derived CAR-MICA/B NK cell immunotherapy to overcome solid tumor escape from NKG2D-mediated mechanisms of recognition and killing
John Goulding, Mochtar Pribadi, Robert Blum, Wen-I Yeh, Yijia Pan, Svetlana Gaidarova, Chia-Wei Chang, Hui-Yi Chu, Ellen Liu, Shohreh Sikaroodi, Lucas Ferrari de Andrade, Lauren Fong, Janel Huffman, Tom Lee, Ryan Bjordahl, Kai Wucherpfennig, Bahram Valamehr

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A70-A71; DOI: 10.1136/jitc-2020-SITC2020.0114
113 Development of T cell-based immunotherapies to target dormant disseminated breast cancer cells
Erica Goddard, Shivani Srivastava, Stanley Riddell, Cyrus Ghajar

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A70; DOI: 10.1136/jitc-2020-SITC2020.0113
670 Develop a multiplex immunofluorescence panel to identification of distinct complex immune landscapes in pleural effusion liquids from patients with metastatic lung adenocarcinoma
Caddie Laberiano, Luisa Solis, Sinchita Roy Chowdhuri, Edwin Parra

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A707; DOI: 10.1136/jitc-2020-SITC2020.0670
115 Engineered T cells directed at tumors with defined allelic loss
Agi Hamburger, Breanna DiAndreth, Jiajia Cui, Mark Daris, Melanie Munguia, Kiran Deshmukh, Jee-Young Mock, Grace Asuelime, Emily Lim, Michelle Kreke, Talar Tokatlian, Alexander Kamb

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A71; DOI: 10.1136/jitc-2020-SITC2020.0115
119 IL-6 is critical for memory responses elicited by Th17 cells to tumors
Hannah Knochelmann, Connor Dwyer, Aubrey Smith, Megan Wyatt, Guillermo Rangel RIvera, Gregory Lesinski, Zihai Li, Mark Rubinstein, Chrystal Paulos

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A72-A73; DOI: 10.1136/jitc-2020-SITC2020.0119

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