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130 Immunogenic potential of chimeric antigen receptor (CAR)-engineered T cells expressing inducible nuclease-deactivated SpCas9 (dCas9)
Dharmeshkumar Patel, Dharmeshkumar Patel, Angshumala Goswami, Vitaly Balan, Zhifen Yang, Lingyu Li, Sowndharya Rajavel, Alper Kearney, Rona Harari-Steinfeld, Maggie Bobbin, Bing Wang, Alessandra Cesano, Stanley Qi, Francesco Marincola

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A80; DOI: 10.1136/jitc-2020-SITC2020.0130
133 Development of novel cellular therapeutics for metastatic and primary CNS malignancies
Paul Rennert, Alyssa Birt, Lihe Su, Lan Wu, Fay Dufort, Roy Lobb, Christine Ambrose, Paul Rennert

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A81; DOI: 10.1136/jitc-2020-SITC2020.0133
136 Targeting MET with chimeric antigen receptor T cells in hepatocellular carcinoma
Yuan Qin, Anna Qin, Anna Musket, Joseph Lee, Zhi Yao, Giedre Krenciute, Qian Xie

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A82-A83; DOI: 10.1136/jitc-2020-SITC2020.0136
137 Genomics of multiple myeloma influences the expression of CAR T-cell targets
Christina Yu, Brian Walker, G David Roodman, Kun Huang, Michel Sadelain, Fabiana Perna

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A83; DOI: 10.1136/jitc-2020-SITC2020.0137
789 Intratumoral plasmid IL-12 expands CD8+ T cells and induces a clinically validated CXCR3 signature in triple-negative breast cancer
Erika Crosby, Hiroshi Nagata, Melinda Telli, Chaitanya Acharya, Irene Wapnir, Kaitlin Zablotsky, Erica Browning, Reneta Hermiz, Lauren Svenson, Donna Bannavong, Kellie Malloy, David Canton, Christopher Twitty, Takuya Osada, Herbert Lyerly

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A838; DOI: 10.1136/jitc-2020-SITC2020.0789
139 Establishment of canine CAR T cells treatment model for solid tumor immunotherapy development
Shihong Zhang, Karan Kohli, R Graeme Black, Brian Hayes, Cassandra Miller, Mari Maeda-Whitaker, Brett Schroeder, Kraig Abrams, Bernard Seguin, Stephen Gottschalk, Peter Moore, Beverly Torok-Storb, Seth Pollack

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A84-A85; DOI: 10.1136/jitc-2020-SITC2020.0139
793 TG4001 (Tipapkinogene sovacivec) and avelumab for recurrent/metastatic (R/M) human papilloma virus (HPV)-16+ cancers: clinical efficacy and immunogenicity
Christophe Le Tourneau, Philippe Cassier, Frederic Rolland, Sébastien Salas, Jean Marc Limacher, Olivier Capitain, Olivier Lantz, Ana Lalanne, Christina Ekwegbara, Annette Tavernaro, Hakim Makhloufi, Kaidre Bendjama, Jean-Pierre Delord

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A841; DOI: 10.1136/jitc-2020-SITC2020.0793
800 A phase I dose escalation and expansion study of intratumorally administered CV8102 as a single-agent or in combination with anti-PD-1 antibodies in patients with advanced solid tumors
Thomas Eigentler, Lucie Heinzerling, Jürgen Krauss, Carsten Weishaupt, Peter Mohr, Sebastian Ochsenreither, Patrick Terheyden, Juan Martin-Liberal, Marc Oliva, Céleste Lebbe, Michael Fluck, Peter Brossart, Jose Manuel Trigo Perez, Franz-Georg Bauernfeind, Sarah-Katharina Kays, Tobias Seibel, Oliver Schönborn-Kellenberger, Claudia Stosnach, Angelika Daehling, Beate Schmitt-Bormann, Ulrike Gnad-Vogt

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A849; DOI: 10.1136/jitc-2020-SITC2020.0800
140 Adoptive transfer of T cells surface-tethered with IL-12 promote antigen spreading for enhanced anti-tumor efficacy
Ditte Jaehger, Kate Stokes, Hólmfridur Halldórsdóttir, Alvin Pratama, Gulzar Ahmad, Jonathan Nardozzi, Katharine Sackton, Douglas Jones, Thomas Andresen

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A85-A86; DOI: 10.1136/jitc-2020-SITC2020.0140
142 Contextual reprogramming of CAR T cells for the treatment of HER2-expressing cancers
Zhifen Yang, Lingyu Li, Ahu Turkoz, Pohan Chen, Hana Choi, Damla Inel, Stanley Qi, Francesco Marincola

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (Suppl 3) A86-A87; DOI: 10.1136/jitc-2020-SITC2020.0142

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